Radiotherapy for Squamous Cell Carcinoma of the Nasal Vestibule

Abstract

RT results in a high cure rate for T1-T2 and favorable T4 tumors. Surgery and RT result in an improved likelihood of cure for patients with extensive T4.

IMRT for Nasal Tumors – Local Control and Cosmetic Outcome

“…In historic series on cohorts treating nasal vestibule tumors with conventional RT or brachytherapy, local control and overall survival rates range from 67% to 92% and 50% to 90%, respectively [2,4,6,14]. The largest series of the DAHANCA study group including 174 patients with nasal vestibule cancer reports a local control rate and an overall survival rate of 67% and 50% at 5 years, respectively [14] (Table 3).…”

“…In the latter series RT was delivered in opposed lateral fields (KV or MV) or with an anterior electron field +/-brachytherapy boost. Doses range from 54 Gy in 3 Gy single doses to 62-69 Gy in 2 Gy or 2.5 Gy doses [2,4,14]. Langendijk et al observed rhinorrhoe in 45%, nasal dryness in 39% and epistaxis in 15% of the patients as late toxicity (4).…”

“…Wallace et al showed severe late term complications requiring hospitalization and/or surgical intervention in 3 out of 8 postoperatively treated patients. 21% of patients treated with RT only experienced complications which resolved without intervention [2]. IMRT is effective to deliver high doses to target volumes while limiting the dose to adjacent critical structures [12].…”

“…Surgical removal often implies complex reconstruction which may end in disfiguring results and consecutively essential impairment of quality of life. Radiation therapy (RT) can be carried out as external beam or brachytherapy, with good local control rates of 67-92% after 5 years [2][3][4][5][6].…”

Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule: a report of two cases

“…In these cases, the SCC-NV was expected to be supplied by a branch of the external carotid artery, particularly the facial and internal maxillary arteries. Therefore, RAD-PLAT was indicated [11]. Indeed, angiography showed that the internal maxillary and the facial arteries were supplying the tumor.…”