Radiotherapy improves serum fatty acids and lipid profile in breast cancer

Abstract

BackgroundBreast cancer is a disease with diverse clinical symptoms, molecular profiles, and its nature to response its therapeutic treatments. Radiotherapy (RT), along with surgery and chemotherapy is a part of treatment in breast cancer. The aim of present study was to investigate pre and post treatment effects of radiotherapy in serum fatty acids and its lipids profile in patients with breast cancer.MethodsIn this comparative as well as follow up study, Serum fatty acids were performed by gas chromatography to investigate fatty acids and Microlab for analysis of lipid profile.ResultsAmong serum free and total fatty acids the major saturated fatty acids (SFAs) in serum lipids of breast cancer patients (pre and post treated) were stearic acid (18:0) and palmitic acid (16:0). These fatty acids contributed about 35-50% of total fatty acids. The decreased concentrations of linoleic acid (C18:2) and arachidonic acid (C20:4) with a lower ratio of C18:2/C18:1 was found in pretreated breast cancer patients as compared to controls. The n-3/n-6 ratio of breast cancer patients was decreased before treatment but it was 35% increased after treatment. In addition, plasma activity of D6 desaturase was increased in the breast cancer patients, while the activity of D5 desaturase was decreased. Increased levels of SFAs, monounsaturated fatty acids (MUFAs) and decreased polyunsaturated fatty acids (PUFAs) levels in breast cancer patients (pre and post treated) as compared to controls. Serum total cholesterol (TC) (224.4 mg/dL) and low density lipoprotein cholesterol (LDL-C) (142.9 mg/dL) were significantly increased in pretreated breast cancer patients but after the radiotherapy treatment, the TC (150.2 mg/dL) and LDL-C (89.8 mg/dL) were decreased.ConclusionIt seems that RT would have played a potential role in the treatment of BC. After RT the serum levels of PUFAs, TC, and LDL-C are improved. Our study reinforces the important role of RT in the management of BC.The level of PUFAs, TC, and LDL-C can be used as the biomarkers for early diagnosis in individuals with risk of breast cancer.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-017-0481-y) contains supplementary material, which is available to authorized users.

NMR-based metabolomics in real-time monitoring of treatment induced toxicity and cachexia in head and neck cancer: a method for early detection of high risk patients

“…The lipid signals are strongly attenuated in the 1D 1 H JRES NMR spectra, however the analysis of the DIFF spectra (data not shown) did not confirm a correlation between the reduction of serum lipids and the patients’ weight loss. Instead, the observed decrease of the lipid signals was found to correlate with the doses of radiation received by the patients, which is in agreement with the previous observations found in radiotherapy treated head and neck (Srivastava et al 2014; Jelonek et al 2014) and breast cancer patients (Shaikh et al 2017). Lowering of the serum lipids can be explained as being due to a tumor response to the treatment (Shaikh et al 2017).…”

“…Instead, the observed decrease of the lipid signals was found to correlate with the doses of radiation received by the patients, which is in agreement with the previous observations found in radiotherapy treated head and neck (Srivastava et al 2014; Jelonek et al 2014) and breast cancer patients (Shaikh et al 2017). Lowering of the serum lipids can be explained as being due to a tumor response to the treatment (Shaikh et al 2017). The detailed inspection of the lipid peaks (at 0.9 to 1.3 ppm) of the CPMG NMR spectra (Fig.…”

Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy

“…Lipid metabolism is a wide and intertwined network that mediates multiple functions, such as energy production [1], thermoregulation [2] and the synthesis of signaling molecules [3], while studies have demonstrated that abnormal levels of lipids contribute to numerous pathologies such as cardiovascular diseases, metabolic diseases and cancer [4]. Fatty acid imbalances have a prognostic value, as their levels in serum can act as tumor biomarkers, or they can predict responses to therapy in multiple cancer types, including leukemia [5], non-small cell lung cancer [6,7], breast cancer [8] and colorectal cancer [9,10].…”

Study of the Level of Fatty Acids in Erythrocyte Membranes and Serum of Patients With Colorectal Cancer in Novosibirsk

“…Однако последние сообщения по этому поводу в Японии, американских и европейских странах противоречивы [10,[28][29][30]. В мембранах эритроцитов уровень С18:0 оказался выше у больных КРР, чем у пациентов без КРР [31], хотя данные авторов неоднозначны [32][33][34][35][36].…”