Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: Results from five randomized controlled trials

Vernon, Clare C.; Hand, J.W.; Field, S. B.; Machin, David; Whaley, Jill B.; Zee, Jacoba van der; Putten, Wim L.J. van; Rhoon, Gerard C. van; Dijk, J.D.P. van; González, Dionisio González; Liu, Fei‐Fei; Goodman, Phyllis J.; Sherar, Michael D.

doi:10.1016/0360-3016(96)00154-x

Cited by 631 publications

(94 citation statements)

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“…One of the largest studies for the evaluation of hyperthermia was published in 1996 by Vernon et al [18]. A total of 306 lesions were included in this analysis, and the main endpoint was the complete response rate.…”

Section: Resultsmentioning

confidence: 99%

Hyperthermia Is Now Included in the NCCN Clinical Practice Guidelines for Breast Cancer Recurrences: An Analysis of Existing Data

et al. 2015

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Background: Hyperthermia has been included in the 2013 National Comprehensive Cancer Network (NCCN) guidelines as an option for the treatment of breast recurrences. The purpose of this article is to demonstrate the important role of hyperthermia as a therapeutic modality by presenting clinical trials on this subject carried out in the last decades. Materials and Methods: All relevant trials published since 1987 were retrieved from Medline and reviewed. Results: Results show that the addition of hyperthermia to radiotherapy and/or chemotherapy for the treatment of breast cancer enhances treatment response and can increase local control. Conclusion: Further studies are required to evaluate potential benefits of hyperthermia in the treatment of other kinds of superficial tumors.

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Section: Resultsmentioning

confidence: 99%

Hyperthermia Is Now Included in the NCCN Clinical Practice Guidelines for Breast Cancer Recurrences: An Analysis of Existing Data

et al. 2015

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“…Eine Metaanalyse 5 randomisierter Studien hatte gezeigt, dass eine Kombination aus Hyperthermie und Radiotherapie bei Patientinnen mit fortgeschrittenem oder rezidivierendem Mammakarzinom bessere Ergebnisse liefern kann als die Radiotherapie. Den größten Effekt erzielte man dabei bei Patientinnen mit Rezidivläsionen in vorbestrahlten Arealen und einer daraus resultierenden Limitierung der Strahlendosis [20]. Dies wurde in einer aktuelleren Studie bestätigt, in der 109 Patienten mit oberflächlichen Tumoren, davon 70 mit Brust- oder Thoraxwandtumoren, randomisiert entweder nur bestrahlt wurden oder zusätzlich Hyperthermie erhielten.…”

Section: Frage 4: Sind Die Strahlentherapeutischen Maßnahmen Beim Ipsunclassified

Behandlung des lokoregionären Rezidivs unter besonderer Berücksichtigung der HER2-positiven Rezidive

Jackisch¹,

Schneeweiß²,

Untch³

et al. 2013

Breast Care

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“…The complementary radio-thermotherapy produced excellent local control for breast [7] and superficial tumors [8]. However, the overall survival significantly contradicted to the local control; it was worst when hyperthermia was involved in the treatments.…”

Section: Introductionmentioning

confidence: 99%

Hyperthermia Dosing and Depth of Effect

Szász¹,

Peter²,

Vancsik³

et al. 2018

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The penetration depth in the electromagnetic heating could be a crucial factor of its application, when the deep heating is the goal. The capacitive coupling is one of the most popular heating techniques in radiofrequency (RF) heating applications. The matching of the target defines the penetration possibilities. The current matched solution has deeper mathematically defined penetration in RF region than the capacitive plane-wave solution. The same power of application request high voltage with relatively low current for plane-wave inducing, while in current matching it has low voltage with high current. The effective depth of the action in the two solutions do not identical, the penetration defined by the intensity of 1/e portion of the incident beam is higher in the current-matched techniques.

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Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: Results from five randomized controlled trials

Cited by 631 publications

References 30 publications

Hyperthermia Is Now Included in the NCCN Clinical Practice Guidelines for Breast Cancer Recurrences: An Analysis of Existing Data

Hyperthermia Is Now Included in the NCCN Clinical Practice Guidelines for Breast Cancer Recurrences: An Analysis of Existing Data

Behandlung des lokoregionären Rezidivs unter besonderer Berücksichtigung der HER2-positiven Rezidive

Hyperthermia Dosing and Depth of Effect

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