The results of theoretical research and earthquake damage investigation show that seismic response analysis of different plane structure in horizontal direction is different. Dynamic characteristics and seismic response analysis of four kinds of architectural models with different planes were analyzed by using the finite element analysis software. The inherent characteristics and earthquake time-history curves in different intensity level X, Y direction of displacement, velocity, acceleration and angle displace were studied. The results show that the seismic response of the four kinds of structures separates gradually, and the separation gap increases with increase of earthquake intensity. The building structure is safer in the long side direction than that in the short side in lateral earthquake response. The irregular structure can cause strong response in both horizontal in a single direction of earthquake effect. The second floor is a weak layer of the building structure which should be paid more attention to.