RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication

Yamamoto, Yasuhiko; Yamamoto, Hiroshi

doi:10.3389/fendo.2013.00105

Cited by 72 publications

(66 citation statements)

References 24 publications

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“…Corvera et al (38) proposed that during diabetic complications, the early formation of advanced glycation end products associated with hyperglycemia stimulates mechanisms that lead to the recruitment of key components of the inflammatory response. Indeed, studies have shown that the advanced glycation end products receptor-mediated regulation of adiposity and inflammation may result in T2D and diabetic vascular complications (39). Other research has shown that serum levels of IL6, IL17, interferon g, TNFg, IL2, and IL10 were increased in T2D nephropathy (T2DN) Adjusted hazard ratios (HRs) (95% CI) of the relationship between the quintiles (Q) of leukocyte, neutrophil, and lymphocyte counts and the incidence of type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study

Guo

Zhang

et al. 2015

European Journal of Endocrinology

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Aim: It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship between NLR and T2D. In order to evaluate how NLR is related to T2D, we designed a large-scale cross-sectional and prospective cohort study in an adult population. Subjects and methods: Participants were recruited from the Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (nZ87 686) and a prospective (nZ38 074) assessment were performed. Participants without a history of T2D were followed up for w6 years (with a median follow-up of 2.7 years). Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the quintiles of NLR and T2D (covariates: age, sex, BMI, smoking status, drinking status, hypertension, hyperlipidemia, and family history of cardiovascular disease, hypertension, hyperlipidemia, or diabetes). Results: The prevalence and incidence of T2D were 4.9% and 6.8/1000 person-years respectively. The adjusted odds ratio and hazard ratio (95% CI) of the highest NLR quintile were 1.34 (1.21, 1.49) and 1.39 (1.09, 1.78) (both P for trend !0.01) respectively as compared to the lowest quintile of NLR. Leukocyte, neutrophil, and lymphocyte counts do not significantly predict the eventual development of T2D. Conclusion: The present study demonstrates that NLR is related to the prevalence and incidence of T2D, and it suggests that NLR may be an efficient and accurate prognostic biomarker for T2D.

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Section: Discussionmentioning

confidence: 99%

Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study

Guo

Zhang

et al. 2015

European Journal of Endocrinology

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“…RAGE-mediated regulation of adiposity and inflammation may attribute to type 2 diabetes and diabetic vascular complications. 6 RAGE provides a new target for the treatment interventions to reduce and prevent the development of side effects of hyperglycemia. It is possible to make personalized therapy against RAGE to inhibit disease progression.…”

Section: Introductionmentioning

confidence: 99%

Relationship between sRAGE and hsCRP as Markers of Cardiovascular Disease Risk Factors in Diabetic and Non-Diabetic Men with Central Obesity

Hamuaty

Sukmawati

Sandra

2017

Mol Cell Biomed Sci

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Background:Interaction between advanced glycation end product (AGE) and receptor for AGE (RAGE) triggers the escalation of inflammatory cytokine expressions. High-sensitivity C-reactive protein (hsCRP), an important inflammatory marker, has been reported to be modulated by soluble RAGE (sRAGE). However, the relationship between hsCRP and sRAGE in diabetes was not clearly described. Therefore present study was conducted to determine the relationship between sRAGE with hsCRP in men with central obese diabetic and non-diabetic. Materials and Methods: Adult men aged 25-60 years with central obese diabetes and non-diabetes, were recruited. Patient's profiles were collected before the physical and blood examination. Physical examinations were conducted by measuring waist/abdomen, blood pressure, height, and weight. The routine blood test was performed to obtain concentrations of fasting blood glucose, HbA1c, hsCRP and sRAGE level. Results: Fifty-seven subjects with central obese and waist size ≥90 cm were selected. It was found that hsCRP values were significantly different (p=0.000) in HbA1c <6.5% dan HbA1c ≥6.5% groups. There was an inverse relationship between hsCRP and sRAGE levels for both in HbA1c <6.5% (r=-0.073) and HbA1c≥6.5% (r=-0.022) groups. In HbA1c ≥6.5% group, sRAGE showed strong positive correlation with 1 mg/dL ≤ hsCRP <3 mg/dL group (r>0.5). Conclusion:In the early stages of diabetes with hsCRP <1 mg/dL, the protective function was demonstrated with greater sRAGE levels. However, in further phase with 3 ≤ hsCRP < 10 mg/dL, the level of sRAGE was low, which is assumed to be associated with complications. Hence, sRAGE could be suggested as a complementary marker for hsCRP to evaluate diabetic men with central obesity.

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“…Adipose tissue consists of heterogeneous populations of adipocytes, stromal preadipocytes, immune cells, and vascular cells, and it can respond rapidly and dynamically to alterations in nutrient excess caused by enhanced food consumption through adipocyte hypertrophy and hyperplasia (Shoelson et al, 2006). This results in a local infl ammation in adipose tissue that propagates an overall systemic but chronic low-grade infl ammation associated with the development of obesity-related comorbidities such as type 2 diabetes and cardiovascular diseases (Yamamoto and Yamamoto, 2013). The possibility that obesity, and the activation of adipose tissue in particular, may enhance the release of infl ammatory factors that underlie the development of insulin resistance has generated intense interest in the fi eld of diabetes for a number of reasons.…”

mentioning

confidence: 99%

Impact of glycemic control on advanced glycation and inflammation in overweight and obese patients with type 2 diabetes mellitus

Kalninova¹,

Jakuš²,

Glejtkova³

et al. 2014

BLL

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Abstract:Aim: In this study we tried to investigate the impact of glycemic control on parameters of glycation and infl ammation in overweight and obese patients with type 2 diabetes mellitus. Patients and methods: Markers of glycation (HbA 1c , AGEs; measured by HPLC and spectrofl uorimetry, resp.) and infl ammatory markers (IL-6, IL-8, TNF-α, MCP-1; measured by xMAP technology) were assessed in 69 patients with T2DM, of whom 32 were patients were with poor glycemic control (PGC group), 37 patients were with good glycemic control (GGC group) and 23 were healthy blood volunteers. Results: Our results showed that plasma levels of fl uorescent AGEs, IL-6, IL-8, TNF-α, and MCP-1 were signifi cantly increased in PGC and GGC groups in comparison with control group, while the levels were higher in PGC group in comparison with GGC group, but the difference was not signifi cant. We found a positive correlation between AGEs and MCP-1 and between TNF-α and creatinine in PGC group. We found signifi cantly decreased levels of glycated HbA 1c and AGEs in patients who used statins compared to patients who used fi brates. We observed benefi cial impact of treatment with oral antidiabetic (OAD) agents + insulin on levels of IL-8, TNF-α and TAG in comparison with treatment with insulin alone. Conclusions: Despite good glycemic compensation of patients with T2DM, levels of AGEs and infl ammatory markers remained signifi cantly elevated in comparison with healthy controls. There was a benefi cial impact of treatment with OAD agents + insulin in sense of lowering the low-grade infl ammation (Tab. 3, Fig. 7, Ref. 113). Text in PDF www.elis.sk.

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RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication

Cited by 72 publications

References 24 publications

Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study

Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study

Relationship between sRAGE and hsCRP as Markers of Cardiovascular Disease Risk Factors in Diabetic and Non-Diabetic Men with Central Obesity

Impact of glycemic control on advanced glycation and inflammation in overweight and obese patients with type 2 diabetes mellitus

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