Raine Eye Health Study: Design, Methodology and Baseline Prevalence of Ophthalmic Disease in a Birth-cohort Study of Young Adults

Yazar, Seyhan; Forward, Hannah; McKnight, Charlotte; Tan, Alexander; Soloshenko, Alla; Oates, Sandra K; Ang, Wei; Sherwin, Justin C; Wood, Diane P.; Mountain, Jenny; Pennell, Craig E.; Hewitt, Alex W.; Mackey, David A.

doi:10.3109/13816810.2012.755632

Cited by 52 publications

(47 citation statements)

References 19 publications

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“…As part of a comprehensive eye examination, 26 postcycloplegic autorefraction was measured using the Nidek ARK-510A (NIDEK Co. Ltd., Gamagori, Japan) autorefractor. The mean of three consecutive measurements was recorded for each eye.…”

Section: Assessment Of Myopia and Ocular Sun Exposurementioning

confidence: 99%

Myopia Is Associated With Lower Vitamin D Status in Young Adults

Yazar

Hewitt

Black

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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Myopic participants had significantly lower 25(OH)D₃ concentrations. The prevalence of myopia was significantly higher in individuals with vitamin D deficiency compared to the individuals with sufficient levels. Longitudinal studies are warranted to investigate whether higher serum 25(OH)D₃ concentration is protective against myopia or whether it is acting as a proxy for some other biologically effective consequence of sun exposure.

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Section: Assessment Of Myopia and Ocular Sun Exposurementioning

confidence: 99%

Myopia Is Associated With Lower Vitamin D Status in Young Adults

Yazar

Hewitt

Black

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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“…Full details of the study can be found in a previous publication. 11 In brief, 1344 individuals were enrolled in the 20-year follow-up study and completed a comprehensive eye assessment, which included the acquisition and analysis of CUVAF photographs as described in Ref. 11.…”

Section: Retrospective Datamentioning

confidence: 99%

“…9 A similar study using CUVAF photography was conducted in the United Kingdom to investigate the prevalence of CUVAF in a diverse population of European and Middle Eastern eye care practitioners. 10 The CUVAF area was quantified using Adobe Photoshop CS4 Extend (Adobe Systems Inc., San Jose, California) in the Australian studies [5][6][7][8]11 and ImageJ (US National Institute of Health, Bethesda, Maryland) in the United Kingdom study. 10 For each photograph, the region of CUVAF was manually delineated by an assessor, requiring great attention to detail and a steady hand.…”

Section: Introductionmentioning

confidence: 99%

Quantification of sun-related changes in the eye in conjunctival ultraviolet autofluorescence images

et al. 2016

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Abstract. Quantification of sun-related changes in conjunctival ultraviolet autofluorescence (CUVAF) images is a subjective and tedious task, in which reproducibility of results is difficult. Thus, we have developed a semiautomatic method in MATLAB ® to analyze CUVAF images retrospectively. The algorithm was validated on 200 images from 50 randomly selected participants from the Western Australian Pregnancy Cohort (Raine) study 20-year follow-up assessment, in which CUVAF area measurements were available from previous manual analysis. Algorithm performance was compared to manual measurements and yielded better than 95% correspondence in both intra-and interobserver agreement. Furthermore, the semiautomatic method significantly reduced analysis time by 50%.

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“…We performed an exome-wide association analysis of CCT using data from the Western Australian Pregnancy (Raine) Cohort [183]. A sample of 1029 unrelated individuals of European descent and with CCT measures were used to test the association of the 43,435 exonic variants with a MAF>0.25% passing quality control.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, to determine the role of low-frequency coding variants in CCT, we evaluated putative functional coding variants from the Illumina Human Exome array. We performed the association using genotype data from 1029 individuals from the Raine cohort [183].…”

Section: Introductionmentioning

confidence: 99%

Complex trait genetics: mapping, correlation and causation

Partida¹

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Efforts to understand the genetic aetiology of complex traits have gained a lot of momentum in the last decade. Advancement of next generation sequencing and the ever-decreasing price of genotyping platforms have allowed us to carry out a vast number of genome wide association studies (GWAS). Until relatively recently, GWAS was guided by the common disease -common genetic variation paradigm.However, recent findings and developments have made us look at the bigger picture, including rare genetic variation. In addition, methodological developments are guiding the translation of GWAS findings. For instance, diverse statistical methods can be applied on genetically informative data to estimate the genetic correlation between complex diseases. The latter can have important medical implications, as genetically correlated diseases might be responsive to the same treatments. Also, approaches such as Mendelian randomization (MR) can help investigations of causal factors in disease when is unfeasible to carry out randomized control trials.My focus is on the application of statistical methods in complex trait genetics -I cover a range of phenotypes, ranging from eye disease to cancer.

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Raine Eye Health Study: Design, Methodology and Baseline Prevalence of Ophthalmic Disease in a Birth-cohort Study of Young Adults

Abstract: The REHS design and methodology allow comparison with other population-based studies of eye disease. The study established the prevalence of eye disorders in a large sample of predominantly Caucasian young Australian adults.

Cited by 52 publications

References 19 publications

Myopia Is Associated With Lower Vitamin D Status in Young Adults

Myopia Is Associated With Lower Vitamin D Status in Young Adults

Quantification of sun-related changes in the eye in conjunctival ultraviolet autofluorescence images

Complex trait genetics: mapping, correlation and causation

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