Raised Total Thyroxine and Free Thyroxine Index but Normal Free Thyroxine

Hennemann, G; Krenning, Eric P.; Otten, M.H.; Docter, R.; Bos, G.; Visser, Theo J.

doi:10.1016/s0140-6736(79)91080-8

Cited by 119 publications

(28 citation statements)

References 13 publications

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“…Our findings are apparently in contrast with in vivo observations of Mendel and Cavalieri (10) and Hennemann et al (1) in humans and of Cefalu et al ( 11) in rat liver. These authors argue against a special role of albumin in FDH in T4 transport.…”

Section: Discussioncontrasting

confidence: 99%

“…Mean values of total T4 and total T3 serum concentrations in unextracted sera (17.0±1.4 ,ug/100 ml and 141±18 ng/100 ml, respectively) were virtually identical to those measured after ethanol-butanol extraction when corrected for ex- was significantly increased (P < 0.001), because total circulating T4 was increased more than its MCR was reduced. It is noteworthy that the total serum T4 concentrations of our FDH patients varied over a wider range (15.3-19 ,ug/100 ml) than previously reported (1,10). Moreover, a highly significant, inverse correlation was observed between T4 MCR and total T4 concentration (r = 0.96; P < 0.001, Fig.…”

Section: Kinetic Studiessupporting

confidence: 47%

“…In contrast, more recent studies in FDH (10) and in rats injected in the portal vein with serum from FDH subjects (1 1), have ruled out a specific role for albumin, different from TBG, in the transport of T4 into cells. It should be noted that this conclusion has been based on T4 kinetic studies, whereas the data on T3 kinetics are few and incomplete (1).…”

Section: Introductionmentioning

confidence: 97%

“…Familial dysalbuminemic hyperthyroxinemia (FDH)' and familial elevation of thyroxine-binding globulin (TBG) are two hereditary abnormalities ofthe interaction between thyroid hormones and their binding proteins, both leading to euthyroid hyperthyroxinemia (1)(2)(3)(4)(5)(6)(7). In the former, the serum thyroid hormone excess is due to an albumin molecule with an abnormal binding site having a much greater affinity for thyroxine (T4); in the latter, hyperthyroxinemia is due to an increased serum concentration of TBG.…”

Section: Introductionmentioning

confidence: 99%

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Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin.

Bianchi¹,

Iervasi²,

Pilo³

et al. 1987

J. Clin. Invest.

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To investigate the role of thyroxine-binding globulin (TBG) and albumin in the availability of thyroid hormones to peripheral tissues, comprehensive kinetic studies of thyroxine (T4) and triiodothyronine (T3) were carried out in eight subjects with familial dysalbuminemic hyperthyroxinemia (FDH), in four subjects with inherited TBG excess, and in 15 normals. In high-TBG subjects, the reduction of T4 and T3 plasma clearance rates (by 51% and 54%, respectively) was associated with normal daily productions; T4 and T3 distribution volumes were significantly reduced. In FDH subjects T4 clearance was less reduced (by 31%) than in high TBG; consequently T4 production rate was significantly increased (by 42%), T4 and T3 distribution volumes and T3 clearance rate were unchanged. Increased T3 peripheral production in FDH (by 24%) indicates that T4 bound to abnormal albumin is more available to tissues than T4 carried by TBG, thus suggesting an important role of albumin in T4 availability to the periphery.

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Section: Discussioncontrasting

confidence: 99%

Section: Kinetic Studiessupporting

confidence: 47%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin.

Bianchi¹,

Iervasi²,

Pilo³

et al. 1987

J. Clin. Invest.

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“…Theresulting high total plasma concentration of T4 often confuses physicians,b ut does not cause any known disease.T his inherited syndrome is called familial dysalbuminemic hyperthyroxinemia (FDH). [71] Theo ther T4-binding sites mainly allow hydrophobic interactions and are probably occupied by other hydrophobic ligands in vivo.…”

Section: Human Serum Albuminmentioning

confidence: 99%

Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones

et al. 2016

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Thyroid hormones (THs) are secreted by the thyroid gland. They control lipid, carbohydrate, and protein metabolism, heart rate, neural development, as well as cardiovascular, renal, and brain functions. The thyroid gland mainly produces l-thyroxine (T4) as a prohormone, and 5'-deiodination of T4 by iodothyronine deiodinases generates the nuclear receptor binding hormone T3. In this Review, we discuss the basic aspects of the chemistry and biology as well as recent advances in the biosynthesis of THs in the thyroid gland, plasma transport, and internalization of THs in their target organs, in addition to the deiodination and various other enzyme-mediated metabolic pathways of THs. We also discuss thyroid hormone receptors and their mechanism of action to regulate gene expression, as well as various thyroid-related disorders and the available treatments.

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Chemie und Biologie der Schilddrüsenhormon‐Biosynthese und ‐Wirkung

Mondal¹,

Raja²,

Schweizer

et al. 2016

Angewandte Chemie

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Schilddrüsenhormone (THs) werden von der Schilddrüse abgegeben. Sie kontrollieren Fett‐, Kohlenhydrat‐ und Proteinmetabolismus, Herzfrequenz, neuronale Entwicklung sowie kardiovaskuläre, renale und neuronale Funktionen. Die Schilddrüse produziert überwiegend l‐Thyroxin (T4), das als Prohormon fungiert. Durch 5′‐Deiodierung, katalysiert von Iodthyronin‐Deiodasen, wird aktives T3 gebildet, das an den nukleären Schilddrüsenhormon‐Rezeptor bindet. In diesem Aufsatz fassen wir sowohl die grundlegende Chemie und Biologie als auch die neuesten Erkenntnisse zur TH‐Biosynthese, zum Plasmatransport und zur Internalisierung der THs in die Zielorgane, zur Deiodierung und zu einer Vielzahl anderer Enzym‐vermittelter Stoffwechselwege zusammen. Zudem erörtern wir Schilddrüsenhormon‐Rezeptoren, verschiedene Schilddrüsen‐bedingte Krankheiten und deren Therapien.

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Raised Total Thyroxine and Free Thyroxine Index but Normal Free Thyroxine

Cited by 119 publications

References 13 publications

Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin.

Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin.

Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones

Chemie und Biologie der Schilddrüsenhormon‐Biosynthese und ‐Wirkung

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