Raising the bar in postural orthostatic tachycardia syndrome research: Evidence and challenges

Seeley, Marie-Claire; Lau, Dennis H.

doi:10.1016/j.autneu.2021.102790

Cited by 2 publications

(2 citation statements)

References 10 publications

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“… 30 Thus, the healthcare system is required to adapt to upscale the service provision, to increase research funding, to improve the knowledge and skills of physicians and to provide multidisciplinary integrated care to cope with the increasing PASC caseload. 31 …”

Section: Discussionmentioning

confidence: 99%

High Incidence of Autonomic Dysfunction and Postural Orthostatic Tachycardia Syndrome in Patients with Long COVID: Implications for Management and Health Care Planning

Seeley

Gallagher

Ong

et al. 2023

The American Journal of Medicine

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Section: Discussionmentioning

confidence: 99%

High Incidence of Autonomic Dysfunction and Postural Orthostatic Tachycardia Syndrome in Patients with Long COVID: Implications for Management and Health Care Planning

Seeley

Gallagher

Ong

et al. 2023

The American Journal of Medicine

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“…In another study of 107 patients with POTS, severity of orthostatic intolerance symptoms were significantly inversely correlated with both SF-36 physical and mental scales [ 7 ]. While these may represent markers of more severe POTS, further work is needed to delineate the pathophysiological links between myalgic encephalomyelitis/chronic fatigue syndrome and POTS [ 24 ]. It is noteworthy that in our cohort, orthostatic intolerance was the only autonomic subdomain statistically associated with reduced quality of life.…”

Section: Discussionmentioning

confidence: 99%

Poor health-related quality of life in postural orthostatic tachycardia syndrome in comparison with a sex- and age-matched normative population

et al. 2023

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Purpose The effect of postural orthostatic tachycardia syndrome (POTS) on health-related quality of life (HrQoL) remains poorly studied. Here, we sought to compare the HrQoL in individuals with POTS to a normative age-/sex-matched population. Methods Participants enrolled in the Australian POTS registry between 5 August 2021 and 30 June 2022 were compared with propensity-matched local normative population data from the South Australian Health Omnibus Survey. The EQ-5D-5L instrument was used to assess HrQoL across the five domains (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) with global health rating assessed with a visual analog scale (EQ-VAS). A population-based scoring algorithm was applied to the EQ-5D-5L data to calculate utility scores. Hierarchical multiple regression analyses were undertaken to explore predictors of low utility scores. Results A total of 404 participants (n = 202 POTS; n = 202 normative population; median age 28 years, 90.6% females) were included. Compared with the normative population, the POTS cohort demonstrated significantly higher burden of impairment across all EQ-5D-5L domains (all P < 0.001), lower median EQ-VAS (p < 0.001), and lower utility scores (p < .001). The lower EQ-VAS and utility scores in the POTS cohort were universal in all age groups. Severity of orthostatic intolerance symptoms, female sex, fatigue scores, and comorbid diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome were independent predictors of reduced HrQoL in POTS. The disutility in those with POTS was lower than many chronic health conditions. Conclusions This is the first study to demonstrate significant impairment across all subdomains of EQ-5D-5L HrQoL in the POTS cohort as compared with a normative population. Trial registration ACTRN12621001034820

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Raising the bar in postural orthostatic tachycardia syndrome research: Evidence and challenges

Cited by 2 publications

References 10 publications

High Incidence of Autonomic Dysfunction and Postural Orthostatic Tachycardia Syndrome in Patients with Long COVID: Implications for Management and Health Care Planning

High Incidence of Autonomic Dysfunction and Postural Orthostatic Tachycardia Syndrome in Patients with Long COVID: Implications for Management and Health Care Planning

Poor health-related quality of life in postural orthostatic tachycardia syndrome in comparison with a sex- and age-matched normative population

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