Ralstonia mannitollylitica endocarditis: A case report

Carreira, Marta; Gomes, Clara; Silva, Margarida; Duro, Raquel

doi:10.1016/j.idcr.2020.e01003

Cited by 8 publications

(8 citation statements)

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“…In a case of infective endocarditis by R. mannitolilytica, carbapenems were found resistant and isolate was susceptible to only ciprofloxacin and co-trimoxazole. After two weeks of therapy, ciprofloxacin was found resistant thus showing the capacity of the organism to acquire resistance [19]. The isolate in our case was found susceptible to imipenem, cefepime and cefoperazone/ sulbactam.…”

Section: Discussionmentioning

confidence: 50%

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Ralstonia mannitolilytica Bacteremia in an Immunocompromised Patient: Case Report and Review

Deshkar¹

2022

ijcsrr

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Ralstonia mannitolilytica is an emerging opportunist pathogen reported in many healthcare facilities over the years. We report a case with R. mannitolilytica bacteraemia in breast carcinoma patient with chemo port. Identification of this non fermentative, Gram negative bacilli was done by Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI TOF MS). A minireview of cases of R. mannitolilytica bacteremia in the recent years with special reference to those reported in India is done.

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Section: Discussionmentioning

confidence: 50%

“…high grade fever, chills and neutrophilic leukocytosis. Majority of the patients were neonates, immunodeficient with frequent hospital visits or indwelling devices [4,5,10,[12][13][14][15][16][17][18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Ralstonia mannitolilytica Bacteremia in an Immunocompromised Patient: Case Report and Review

Deshkar¹

2022

ijcsrr

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“…Of late several case reports of infections by R. mannitolilytica have been seen from India and worldwide [4–12]. Many case reports have highlighted R.…”

Section: Introductionmentioning

confidence: 99%

“…R. mannitolilytica are known to cause sepsis, meningitis and central venous catheterassociated bacteraemia [3]. Of late several case reports of infections by R. mannitolilytica have been seen from India and worldwide [4][5][6][7][8][9][10][11][12]. Many case reports have highlighted R. mannitolilytica as causing bacteraemia and sepsis [4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Lampropoulos et al (2021) and Rajendran et al (2022) highlighted the organism as an emerging opportunistic pathogen causing sepsis in neonatal intensive care units [9,10] . Carreira et al (2020) emphasized the role of R. mannitolilytica in endocarditis [12]. The tendency of R.mannitolilytica to form biofilm enhances the organism's survival in the environment (including the hospital environment), and plays a role in frequent antibiotic resistance [13].…”

Section: Introductionmentioning

confidence: 99%

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Ralstonia mannitolilytica: an emerging multidrug-resistant opportunistic pathogen in a tertiary care hospital setting

Siddiqui

Patel

Sinha

et al. 2022

Access Microbiology

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Introduction. Ralstonia mannitolilytica is a rare opportunistic pathogen capable of causing a serious infection in immunocompromised patients. Our objective was to describe all cases of R. mannitolilytica bloodstream infection identified within 2 years at our tertiary care centre, focusing on clinical characteristics, risk factors, antibiotic sensitivity patterns, management and outcomes. Case Series. We compiled a descriptive case series including 14 non-duplicate R. mannitolilytica isolates obtained from bloodstream infection samples from the microbiology laboratory of a tertiary care centre from June 2019 to June 2021. All isolates were initially identified based on their morphological properties and biochemical reactions, and then underwent matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) examination for confirmation of identity. Antibiotic susceptibility testing was performed using the Kirby–Bauer disc diffusion method and Vitek 2. All 14 patients presented with symptoms of fever and/or chills, and a positive blood culture for R. mannitolilytica . After 48 h of incubation, no Ralstonia growth was reported from any of the current environmental or pharmaceutical water samples. Chemotherapy (9/14), mechanical ventilation (4/14), steroid use (2/14) and diabetes mellitus (1/14) were associated risk factors in our patients. The antibiotic sensitivity panel showed maximum resistance to aminoglycosides (64.3%) and no resistance to cefoperazone/sulbactum. Patients received treatment with cefoperazone/sulbactum and meropenem or ceftazidime. Thirteen patients recovered with antibiotic therapy and one patient succumbed to his illness. Conclusion. R. mannitolilytica can cause bloodstream infections in immunocompromised patients. It is likely to be missed or underreported due to lack of clinical awareness. MALDI-TOF MS is helpful in rapid identification. R. mannitolilytica is resistant to many routinely used antibiotics, including carbapenems.

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Ceftazidime/ciprofloxacin

2021

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Ralstonia mannitollylitica endocarditis: A case report

Abstract: Highlights Ralstonia mannitolilytica infective endocarditis is extremely rare. Early recognition and correct approach is critical. Antimicrobial treatment is difficult, especially in the presence of resistance.

Cited by 8 publications

References 10 publications

Ralstonia mannitolilytica Bacteremia in an Immunocompromised Patient: Case Report and Review

Ralstonia mannitolilytica Bacteremia in an Immunocompromised Patient: Case Report and Review

Ralstonia mannitolilytica: an emerging multidrug-resistant opportunistic pathogen in a tertiary care hospital setting

Ceftazidime/ciprofloxacin

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