2024
DOI: 10.3389/fbioe.2024.1399938
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Raman-based PAT for VLP precipitation: systematic data diversification and preprocessing pipeline identification

Annabelle Dietrich,
Robin Schiemer,
Jasper Kurmann
et al.

Abstract: Virus-like particles (VLPs) are a promising class of biopharmaceuticals for vaccines and targeted delivery. Starting from clarified lysate, VLPs are typically captured by selective precipitation. While VLP precipitation is induced by step-wise or continuous precipitant addition, current monitoring approaches do not support the direct product quantification, and analytical methods usually require various, time-consuming processing and sample preparation steps. Here, the application of Raman spectroscopy combine… Show more

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