Raman spectroscopy: A prospective intraoperative visualization technique for gliomas

Abstract

The infiltrative growth and malignant biological behavior of glioma make it one of the most challenging malignant tumors in the brain, and how to maximize the extent of resection (EOR) while minimizing the impact on normal brain tissue is the pursuit of neurosurgeons. The current intraoperative visualization assistance techniques applied in clinical practice suffer from low specificity, slow detection speed and low accuracy, while Raman spectroscopy (RS) is a novel spectroscopy technique gradually developed and applied to clinical practice in recent years, which has the advantages of being non-destructive, rapid and accurate at the same time, allowing excellent intraoperative identification of gliomas. In the present work, the latest research on Raman spectroscopy in glioma is summarized to explore the prospect of Raman spectroscopy in glioma surgery.

Advancing Brain Research through Surface-Enhanced Raman Spectroscopy (SERS): Current Applications and Future Prospects

“…SERS is emerging as a powerful tool in the realm of intraoperative brain mapping and real-time monitoring of gliomas. Various adjuncts have been proposed to aid neurosurgeons while operating on brain tumors to maximize the extent of resection in the surgical treatment of gliomas, including intraoperative fluorescence-guided microsurgery, intraoperative MRI (iMRI), intraoperative ultrasound (IOUS), intraoperative neuro-navigation, intraoperative frozen section, and intraoperative fluorescence-guided microsurgery [72].…”

Data augmentation method based on the Gaussian kernel density for glioma diagnosis with Raman spectroscopy

“…It lays the foundation for the rapid, non-invasive, and accurate determination of tumor properties and tumor boundaries in the future. 14 Raman spectra can detect feature information at the molecular level. 15 When excited by a laser, most of the photons scattered from the molecule are elastically scattered.…”

“…It lays the foundation for the rapid, non-invasive, and accurate determination of tumor properties and tumor boundaries in the future. 14…”