Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions

Hamlin, Trevor A.; Leadbeater, Nicholas E.

doi:10.3762/bjoc.9.215

Cited by 29 publications

(20 citation statements)

References 53 publications

(41 reference statements)

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“…Several in-line monitoring tools, for example, ReactIR [58][59][60][61][62] and flow based NMR [63][64][65][66] which allow for substrate specific, nonconsuming analysis, have also been developed. Other in-line techniques employing simple UV [67][68][69][70], MS [71][72][73], and Raman [74][75][76][77] analysis have also been successfully applied enabling efficient optimisation and generation of new reaction chemistry.…”

Section: The Advantages Of a Flow Approachmentioning

confidence: 99%

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Gambacorta¹,

Sharley²,

Baxendale³

2021

Beilstein J. Org. Chem.

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Due to their intrinsic physical properties, which includes being able to perform as volatile liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal candidates for continuous-flow manufacturing. This review highlights the potential crossover between a multibillion dollar industry and the flourishing sub-field of flow chemistry evolving within the discipline of organic synthesis. This is illustrated through selected examples of industrially important transformations specific to the fragrances and flavours industry and by highlighting the advantages of conducting these transformations by using a flow approach. This review is designed to be a compendium of techniques and apparatus already published in the chemical and engineering literature which would constitute a known solution or inspiration for commonly encountered procedures in the manufacture of fragrance and flavour chemicals.

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Section: The Advantages Of a Flow Approachmentioning

confidence: 99%

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Gambacorta¹,

Sharley²,

Baxendale³

2021

Beilstein J. Org. Chem.

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show abstract

“…The use of Raman spectroscopy has recently been reported for the continuous monitoring of mesofluidic scale flow syntheses 41. An off‐the‐shelf spectroscopic flow cell was placed into an assembly that enabled the position of the Raman light source to be adjusted to optimize the intensity of the gathered signal.…”

Section: Analytical Toolsmentioning

confidence: 99%

Organic Synthesis: March of the Machines

et al. 2015

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Organic synthesis is changing; in a world where budgets are constrained and the environmental impacts of practice are scrutinized, it is increasingly recognized that the efficient use of human resource is just as important as material use. New technologies and machines have found use as methods for transforming the way we work, addressing these issues encountered in research laboratories by enabling chemists to adopt a more holistic systems approach in their work. Modern developments in this area promote a multi-disciplinary approach and work is more efficient as a result. This Review focuses on the concepts, procedures and methods that have far-reaching implications in the chemistry world. Technologies have been grouped as topics of opportunity and their recent applications in innovative research laboratories are described.

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“…Über Raman‐Spektroskopie zur kontinuierlichen Verfolgung von Strömungssynthesen im mesofluidischen Maßstab wurde kürzlich berichtet 41. Eine handelsübliche spektroskopische Durchflusszelle wurde in einer Anordnung platziert, die es gestattete, die Position der Raman‐Lichtquelle so zu ändern, dass sich die Intensität des erhaltenen Signals optimieren ließ.…”

Section: Analytikunclassified

Organische Synthese: Vormarsch der Maschinen

et al. 2015

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Die organische Synthese ist im Wandel begriffen: Da Forschungsetats zunehmend gekürzt werden und der Einfluss chemischer Verfahren auf die Umwelt genau geprüft wird, wird immer deutlicher, dass der effiziente Einsatz von Personal im Labor mindestens so bedeutsam ist wie die Materialverwendung. Neue Techniken und Maschinen verändern unsere Arbeitsweise, und indem die zuvor genannten Punkte — Personal und Material – erfasst werden, ermöglichen sie es Chemikern in Forschungslaboratorien, einen eher ganzheitlichen Ansatz für ihre Tätigkeit zu finden. Moderne Entwicklungen auf diesem Gebiet fördern multidisziplinäres Vorgehen mit dem Ergebnis effizienterer Arbeit. Dieser Aufsatz behandelt die Konzepte, Verfahren und Methoden, die weitreichende Implikationen für die Chemie insgesamt haben. Thematisch ist der Aufsatz nach unterschiedlichen Anwendungsmöglichkeiten gegliedert, und neuere Anwendungen in innovativen Forschungslabors werden beschrieben.

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Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions

Cited by 29 publications

References 53 publications

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Organic Synthesis: March of the Machines

Organische Synthese: Vormarsch der Maschinen

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