Ramelteon modulates gamma oscillations in the rat primary motor cortex during non-REM sleep

Yoshimoto, Airi; Yamashiro, Kotaro; Suzuki, Takeshi; Ikegaya, Yuji; Matsumoto, Nobuyoshi

doi:10.1016/j.jphs.2020.11.006

Cited by 17 publications

(18 citation statements)

References 48 publications

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“…A recording interface assembly was prepared as previously described ( Okada et al, 2016 ; Sasaki et al, 2017 ; Shikano et al, 2018 ; Yoshimoto et al, 2021b ). In short, the assembly was composed of an electrical interface board (EIB; EIB‐36‐PTB, Neuralynx) and custom-made shell and core bodies created by three-dimensional (3-D) printers.…”

Section: Methodsmentioning

confidence: 99%

Enhancement of Motor Cortical Gamma Oscillations and Sniffing Activity by Medial Forebrain Bundle Stimulation Precedes Locomotion

Yoshimoto

Shibata

Kudara

et al. 2022

eNeuro

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The medial forebrain bundle (MFB) is a white matter pathway that traverses through mesolimbic structures and includes dopaminergic neural fibers ascending from the ventral tegmental area (VTA). Since dopaminergic signals represent hedonic responses, electrical stimulation of the MFB in animals has been used as a neural reward for operant and spatial tasks. MFB stimulation strongly motivates animals to rapidly learn to perform a variety of behavioral tasks to obtain a reward. Although the MFB is known to connect various brain regions and MFB stimulation dynamically modulates animal behavior, how central and peripheral functions are affected by MFB stimulation per se is poorly understood. To address this question, we simultaneously recorded electrocorticograms (ECoGs) in the primary motor cortex (M1), primary somatosensory cortex (S1), and olfactory bulb (OB) of behaving rats while electrically stimulating the MFB. We found that MFB stimulation increased the locomotor activity of rats. Spectral analysis confirmed that immediately after MFB stimulation, sniffing activity was facilitated and the power of gamma oscillations in the M1 was increased. After sniffing activity and motor cortical gamma oscillations were facilitated, animals started to move. These results provide insight into the importance of sniffing activity and cortical gamma oscillations for motor execution and learning facilitated by MFB stimulation.

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Section: Methodsmentioning

confidence: 99%

Enhancement of Motor Cortical Gamma Oscillations and Sniffing Activity by Medial Forebrain Bundle Stimulation Precedes Locomotion

Yoshimoto

Shibata

Kudara

et al. 2022

eNeuro

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“…The doses of hypnotics used were based on previous studies in rodents to promote sleep. The half-life in rodents of caffeine is 40–60 min ( Hartmann and Czok, 1980 ), DORA-22 is 37.8 min ( Gotter et al, 2013 ), ramelteon is less than 60 min ( Yoshimoto et al, 2021 ), and zolpidem is about 20 min ( Garrigou-Gadenne et al, 1989 ). Drug treatments were assigned in a paired design (one WT and one Fmr1 KO mouse per treatment group per study group).…”

Section: Methodsmentioning

confidence: 99%

Effects of Treatment With Hypnotics on Reduced Sleep Duration and Behavior Abnormalities in a Mouse Model of Fragile X Syndrome

2022

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Many patients with fragile X syndrome (FXS) have sleep disturbances, and Fmr1 knockout (KO) mice (a model of FXS) have reduced sleep duration compared to wild type (WT). Sleep is important for brain development, and chronic sleep restriction during development has long-lasting behavioral effects in WT mice. We hypothesized that the sleep abnormalities in FXS may contribute to behavioral impairments and that increasing sleep duration might improve behavior. We treated adult male Fmr1 KO and WT mice subacutely with three different classes of hypnotics (DORA-22, ramelteon, and zolpidem) and caffeine, a methylxanthine stimulant, and we tested the effects of treatments on sleep duration and behavior. Behavior tests included activity response to a novel environment, anxiety-like behavior, and social behavior. As expected, all hypnotics increased, and caffeine decreased sleep duration in the circadian phase in which drugs were administered. Caffeine and DORA-22 treatment significantly reduced activity in the open field regardless of genotype. Other effects were not as apparent.

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“…Preparation A recording interface assembly was prepared as previously described. [31][32][33] In short, the assembly was composed of an electrical interface board (EIB) (EIB-36-PTB, Neuralynx, Inc., Bozeman, MT, U.S.A.) and shell and core bodies custom-made by a three-dimensional printer. The EIB had a sequence of metal holes for connections with wire electrodes.…”

Section: Ethical Approvalsmentioning

confidence: 99%

“…After we confirmed that depth of anesthesia was adequate, we implanted electrodes for ECGs, EMGs, and ECoGs as previously described. 33,35) Briefly, we placed a rat onto a stereotaxic apparatus (SR-6R-HT, Narishige, Tokyo, Japan). 36) We attached one wire electrode to the left pectoralis muscle to record cardiac signals (ECGs), whereas we implanted another electrode into the trapezius to record myogenic potentials (EMGs).…”

Section: Ethical Approvalsmentioning

confidence: 99%

“…To address this question, we simultaneously recorded electrocardiograms (ECGs), electromyograms (EMGs), and electrocorticograms (ECoGs) in the frontal cortex (Fr) and the olfactory bulb (OB) of unrestrained rats treated with ramelteon and vehicle. [31][32][33] We classified murine behavior into three vigilance states (i.e., awake, REM sleep, and non-REM sleep) based on neural oscillatory activity in the OB and the Fr and physiologically investigated the modulation of cardiac signals by ramelteon administration.…”

Section: Introductionmentioning

confidence: 99%

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Acute Ramelteon Treatment Maintains the Cardiac Rhythms of Rats during Non-REM Sleep

Yoshimoto

Yamashiro

Ikegaya

et al. 2021

Biological & Pharmaceutical Bulletin

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Sleep curtailment negatively affects cardiac activities and thus should be ameliorated by pharmacological methods. One of the therapeutic targets is melatonin receptors, which tune circadian rhythms. Ramelteon, a melatonin MT 1 /MT 2 receptor agonist, has recently been developed to modulate sleep-wake rhythms. To date, the sleep-promoting effect of ramelteon has been widely delineated, but whether ramelteon treatment physiologically influences cardiac function is not well understood. To address this question, we recorded electrocardiograms, electromyograms, and electrocorticograms in the frontal cortex and the olfactory bulb of unrestrained rats treated with either ramelteon or vehicle. We detected vigilance states based on physiological measurements and analyzed cardiac and muscular activities. We found that during non-rapid eye movement (non-REM) sleep, heartrate variability was maintained by ramelteon treatment. Analysis of the electromyograms confirmed that neither microarousal during non-REM sleep nor the occupancy of phasic periods during REM sleep was altered by ramelteon. Our results indicate that ramelteon has a remedial effect on cardiac activity by keeping the heartrate variability and may reduce cardiac dysfunction during sleep.

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Ramelteon modulates gamma oscillations in the rat primary motor cortex during non-REM sleep

Cited by 17 publications

References 48 publications

Enhancement of Motor Cortical Gamma Oscillations and Sniffing Activity by Medial Forebrain Bundle Stimulation Precedes Locomotion

Enhancement of Motor Cortical Gamma Oscillations and Sniffing Activity by Medial Forebrain Bundle Stimulation Precedes Locomotion

Effects of Treatment With Hypnotics on Reduced Sleep Duration and Behavior Abnormalities in a Mouse Model of Fragile X Syndrome

Acute Ramelteon Treatment Maintains the Cardiac Rhythms of Rats during Non-REM Sleep

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