Randomised clinical trial: a herbal preparation of myrrh, chamomile and coffee charcoal compared with mesalazine in maintaining remission in ulcerative colitis - a double-blind, double-dummy study

Langhorst, Jost; Varnhagen, I.; Schneider, Simone; Albrecht, Uwe; Rueffer, Andreas; Stange, Rainer; Michalsen, Andreas; Dobos, Gustav

doi:10.1111/apt.12397

Cited by 92 publications

(58 citation statements)

References 35 publications

(41 reference statements)

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“…Relapse rates were 45% in the 5-ASA treatment group 53% in the herbal treatment group which was interpreted as non-inferiority in maintenance therapy of UC patients [96].…”

Section: Therapies With Natural Compounds (Anthocyanins Curcuma and mentioning

confidence: 93%

Where are we heading to in pharmacological IBD therapy?

Rogler

2015

Pharmacological Research

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“…Relapse rates were 45% in the 5-ASA treatment group 53% in the herbal treatment group which was interpreted as non-inferiority in maintenance therapy of UC patients [96].…”

Section: Therapies With Natural Compounds (Anthocyanins Curcuma and mentioning

confidence: 93%

Where are we heading to in pharmacological IBD therapy?

Rogler

2015

Pharmacological Research

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“…In der nun erfolgten Leitlinienaktualisierung hat der Stellenwert komplementärmedizinischer Behandlungsverfahren weiter zugenommen. Neue hochwertige kontrolliert-randomisierte Studien ermöglichten die Ergänzung der bereits vorhandenen Empfehlungen um weitere komplementärmedizinische Therapieverfahren [3,4,5]: Yoga (Empfehlung 6.2.6) und ein pflanzliches Kombinationspräparat aus Myrrhe, Kamillenblütenextrakt und Kaffeekohle (Empfehlung 6.2.10) - für das es in Deutschland ein zugelassenes traditionelles Arzneimittel gibt - können nun leitlinienkonform komplementär in der Behandlung eingesetzt werden. Innerhalb des Unterkapitels «Mind-Body Verfahren» wird weiterhin auch die Lebensstilmodifikation thematisiert - ein besonders vielversprechender Therapieansatz, da er eine Vielzahl von Ansätzen aus der Komplementärmedizin enthält.…”

Section: Tableunclassified

Komplementäre Therapieverfahren in der aktualisierten AWMF-S3-Leitlinie «Diagnostik und Therapie der Colitis ulcerosa»: Der Stellenwert von Therapieansätzen aus dem komplementären Bereich nimmt weiter zu

Koch¹,

Cramer²,

Klose³

et al. 2018

Complement Med Res

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“…Their flowers contain antioxidant and anti-inflammatory compounds such as bisabolol, chamazulene, apigenin, and luteolin [60] . Two random double-blind controlled studies on UC patients found that a chamomile preparation which also contained myrrh and coffee charcoal was as effective as mesalamine [61,62] . However, since the preparation contained many components, one cannot assign the beneficial effects to chamomile alone.…”

Section: Chamomilementioning

confidence: 99%

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

2017

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The gastrointestinal tract digests and absorbs dietary nutrients, protects the body against physical and chemical damage from contents in its lumen, provides immunity against external antigens, and keeps an optimum environment for the gut microbiota. These functions cannot be performed normally in several diseases of which the following are discussed here: irritable bowel syndrome and inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Because these diseases are associated with oxidative stress, a host of antioxidant supplements are used for maintenance and recovery of the gut functions. However, the benefits of these supplements have not been established. The available 80 human trials were rated for levels of confidence and for benefits of the antioxidant supplements. For Crohn's disease, the supplements for which clear benefits occurred in at least 2 studies were allopurinol, Boswellia serrata (frankincense or shallaki), Artemesia species (wormwood), Tripterygium wilfordii (léi gōng téng), and omega-3 fatty acids. Similar beneficial supplements for ulcerative colitis were allopurinol, Matricaria chamomilla (chamomile), Curcuma longa (curcumin in turmeric), and omega-3 fatty acids. There was also a clear benefit for ulcerative colitis in 2 studies where a multiherbal Chinese medicine preparation and an Ayurvedic medicine preparation were used. For irritable bowel syndrome, there was only a marginal benefit of some of the antioxidant supplements. Thus, some antioxidant supplements may be beneficial at certain stages of specific diseases. This is consistent with the current concept that antioxidants act by inhibiting oxidative stress pathways in a tissue- and environment-specific manner and not by simply acting as scavengers.

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Randomised clinical trial: a herbal preparation of myrrh, chamomile and coffee charcoal compared with mesalazine in maintaining remission in ulcerative colitis - a double-blind, double-dummy study

Cited by 92 publications

References 35 publications

Where are we heading to in pharmacological IBD therapy?

Where are we heading to in pharmacological IBD therapy?

Komplementäre Therapieverfahren in der aktualisierten AWMF-S3-Leitlinie «Diagnostik und Therapie der Colitis ulcerosa»: Der Stellenwert von Therapieansätzen aus dem komplementären Bereich nimmt weiter zu

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

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