2016
DOI: 10.1016/j.tvjl.2016.05.003
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Randomised clinical trial on the effect of a single oral administration of l-tryptophan, at three dose rates, on reaction speed, plasma concentration and haemolysis in horses

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Cited by 4 publications
(2 citation statements)
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“…Plasma homocysteine in horse is within the normal range for humans (<15 µM) 160 and Trp is not toxic to horse, at least at doses of up to 120 mg/kg body weight (producing blood Trp levels of 350 µM). 161 Trp exerts no effect on reaction time to startle or clinical pathology parameters in horse. The above authors observed no calmative effect of Trp (ie, for the horse to travel at a lower speed).…”
Section: Fate Of Plasma Tryptophan In Speciesmentioning
confidence: 87%
“…Plasma homocysteine in horse is within the normal range for humans (<15 µM) 160 and Trp is not toxic to horse, at least at doses of up to 120 mg/kg body weight (producing blood Trp levels of 350 µM). 161 Trp exerts no effect on reaction time to startle or clinical pathology parameters in horse. The above authors observed no calmative effect of Trp (ie, for the horse to travel at a lower speed).…”
Section: Fate Of Plasma Tryptophan In Speciesmentioning
confidence: 87%
“…The few studies in which TRP has been administered to horses suggest that low doses cause mild excitation. However, high doses reduce endurance capacity and cause acute hemolytic anemia when given orally due to the presence of a toxic metabolite in the intestine [65,66]. Despite questions about its effectiveness, TRP is marketed as an equine sedative and is related to sedation, inhibition of aggression, fear, and stress.…”
Section: Behavioral Alterations: Stereotypesmentioning
confidence: 99%