Randomised controlled feasibility trial on the use of medical grade honey following microvascular free tissue transfer to reduce the incidence of wound infection

Robson, Val; Yorke, Janelle; Sen, Rachel A.; Lowe, Derek; Rogers, Simon N.

doi:10.1016/j.bjoms.2011.07.014

Cited by 34 publications

(37 citation statements)

References 21 publications

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“…To determine the size of the study population, a power analysis was performed in advance in 11 of the 25 RCTs [15,27,34,35,68,69,[73][74][75][76][77]. In only 4 of the 11 studies, the required number of participants was recruited [27,68,76,77].…”

Section: Methodology Of the Included Studiesmentioning

confidence: 99%

“…Although several studies report that honey application reduces the costs of care [38,40,41,44,[47][48][49][50]64,[66][67][68][69][70][71][72][73], only one RCT actually calculated the cost-effectiveness of honey and the control therapy by using the Incremental Cost-Effectiveness Ratio (ICER), and it was found to be more profitable for the control therapy [27].…”

Section: Outcomes Of the Included Studiesmentioning

confidence: 99%

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Honey in modern wound care: A systematic review

Vandamme

Heyneman

Hoeksema

et al. 2013

Burns

177

116

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Section: Methodology Of the Included Studiesmentioning

confidence: 99%

Section: Outcomes Of the Included Studiesmentioning

confidence: 99%

Honey in modern wound care: A systematic review

Vandamme

Heyneman

Hoeksema

et al. 2013

Burns

177

116

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“…Literature reports varied results for honey depending on the infected wound [144] and also it has been demonstrated that honey may even have a detrimental effect on diabetic ulcers [145]. These contradictory results indicate that more information is needed and multi-center clinical trials and with a larger number of patients are required to show a clinical benefit for honey to reduce the incidence of wound infection [146]. …”

Section: Essential Oils Honey Aloe Vera Cationic Peptides and Omentioning

confidence: 99%

“…As previously mentioned (Section 4.1), honey impregnated dressings were tested by different researchers with controversial results [139,141,142,143,146], suggesting that the benefits of adding honey to dressings to reduce the rates of wound infection deserves further research.…”

Section: Combination Of Nanostructured Dressings With Essential Oilsmentioning

confidence: 99%

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

et al. 2015

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A fast and effective wound healing process would substantially decrease medical costs, wound care supplies, and hospitalization significantly improving the patients’ quality of life. The search for effective therapeutic approaches seems to be imperative in order to avoid the aggravation of chronic wounds. In spite of all the efforts that have been made during the recent years towards the development of artificial wound dressings, none of the currently available options combine all the requirements necessary for quick and optimal cutaneous regeneration. Therefore, technological advances in the area of temporary and permanent smart dressings for wound care are required. The development of nanoscience and nanotechnology can improve the materials and designs used in topical wound care in order to efficiently release antimicrobial, anti-inflammatory and regenerative compounds speeding up the endogenous healing process. Nanostructured dressings can overcome the limitations of the current coverings and, separately, natural origin components can also overcome the drawbacks of current antibiotics and antiseptics (mainly cytotoxicity, antibiotic resistance, and allergies). The combination of natural origin components with demonstrated antibiotic, regenerative, or anti-inflammatory properties together with nanostructured materials is a promising approach to fulfil all the requirements needed for the next generation of bioactive wound dressings. Microbially compromised wounds have been treated with different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring antimicrobial, anti-inflammatory, and regenerative components but the available evidence is limited and insufficient to be able to draw reliable conclusions and to extrapolate those findings to the clinical practice. The evidence and some promising preliminary results indicate that future comparative studies are justified but instead of talking about the beneficial or inert effects of those natural origin occurring materials, the scientific community leads towards the identification of the main active components involved and their mechanism of action during the corresponding healing, antimicrobial, or regenerative processes and in carrying out systematic and comparative controlled tests. Once those natural origin components have been identified and their efficacy validated through solid clinical trials, their combination within nanostructured dressings can open up new avenues in the fabrication of bioactive dressings with outstanding characteristics for wound care. The motivation of this work is to analyze the state of the art in the use of different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring materials as antimicrobial, anti-inflammatory and regenerative components with the aim of clarifying their potential clinical use in bioactive dressings. We conclude that, for those natural occurring materials, more clinical trials are needed to reach a sufficient level ...

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“…Hierzu gehören Verbrennungen, diabetische Ulzera aber auch die Psoriasis und chronische Wunden bei Tumorpatienten[ 25 ] . In einer randomisiert angelegten klinischen Studie konnte beispielsweise gezeigt werden, dass es bei einer vergleichbar hohen MRSA-Keimbesiedlung durch die prophylaktische postoperative Anwendung von medizinischem Honig auf den Operationswunden es zu einer signifi kanten Reduktion der stationären Aufenthaltsdauer gekommen ist[ 27 ] . Es handelte sich hierbei um größ-tenteils vorbestrahlte Patienten mit einem Oropharynx-Karzinom-Rezidiv, welches im Sinne eines salvage-chirurgischen Therapiekonzepts zunächst reseziert und der entstandene Defekt dann mittels mikrovaskulär-anastomosierten Radialistransplantat rekonstruiert wurde.Die Vorteile der topischen Applikation von medizinischem Honig im Vergleich zu herkömmlichen Wundbehandlungen sind: 1. autolytisches Wunddebridement und Granulationsförderung mit Hemmung von unangenehmen Wundgerüchen [ 25 ] , 2. antibakterielle, antifungizide sowie antiseptische Wirkung, insbesondere auch gegenüber Problemkeimen, wie MRSA [ 11 , 28 ] , 3. geringe bzw.…”

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