Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome

Lund, P. A.; Sangild, Per Torp; Aunsholt, Lise; Hartmann, Bolette; Holst, Jens J.; Mortensen, Jann; Mortensen, Per Brøbech; Jeppesen, Palle Bekker

doi:10.1038/ejcn.2012.93

Cited by 27 publications

(32 citation statements)

References 46 publications

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“…Two studies, one in adults and one in children, examining the possible beneficial effect of bovine colostrum in SBS were identified. In both studies, the investigators used whole colostrum sterilized by electron beam irradiation.…”

Section: Discussion and Summary Of Studiesmentioning

confidence: 99%

Clinical applications of bovine colostrum therapy: a systematic review

et al. 2014

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Bovine colostrum, the first milk that cows produce after parturition, contains high levels of growth factors and immunomodulatory components. Some healthy and diseased individuals may gain health benefits by consuming bovine colostrum as a food supplement. This review provides a systematic, critical evaluation of the current state of knowledge in this area. Fifty‐one eligible studies were identified from the following databases: Medline, Embase, Global Health, the Cochrane Library, and the Cumulative Index to Nursing and Allied Health Literature. Studies were heterogeneous with regard to populations, outcomes, and methodological quality, as judged by the Jadad assessment tool. Many studies used surrogate markers to study the effects of bovine colostrum. Studies suggesting clinical benefits of colostrum supplementation were generally of poor methodological quality, and results could not be confirmed by other investigators. Bovine colostrum may provide gastrointestinal and immunological benefits, but further studies are required before recommendations can be made for clinical application. Animal models may help researchers to better understand the mechanisms of bovine colostrum supplementation, the dosage regimens required to obtain clinical benefits, and the optimal methods for testing these effects in humans.

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Section: Discussion and Summary Of Studiesmentioning

confidence: 99%

Clinical applications of bovine colostrum therapy: a systematic review

et al. 2014

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“…The macronutrient composition was analyzed by a milkoScan analyzer (FOSS; WPC for the MF diet) or provided by the producer (AFI; WPC for the CF and GF diets). The macronutrient composition of BC was analyzed by Eurofins Steins Laboratorium (Holstebro) (22). LF, IgG, IGF-I, and TGFb2 were analyzed as the bioactive markers.…”

Section: Methodsmentioning

confidence: 99%

Whey Protein Processing Influences Formula-Induced Gut Maturation in Preterm Pigs

Østergaard

Jiang

et al. 2013

The Journal of Nutrition

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Immaturity of the gut predisposes preterm infants to nutritional challenges potentially leading to clinical complications such as necrotizing enterocolitis. Feeding milk formulas is associated with greater risk than fresh colostrum or milk, probably due to loss of bioactive proteins (e.g., immunoglobulins, lactoferrin, insulin-like growth factor, transforming growth factor-β) during industrial processing (e.g., pasteurization, filtration, spray-drying). We hypothesized that the processing method for whey protein concentrate (WPC) would affect gut maturation in formula-fed preterm pigs used as a model for preterm infants. Fifty-five caesarean-delivered preterm pigs were distributed into 4 groups given 1 of 4 isoenergetic diets: formula containing conventional WPC (filtration, multi-pasteurization, standard spray-drying) (CF); formula containing gently treated WPC (reduced filtration and pasteurization, gentle spray-drying) (GF); formula containing minimally treated WPC (rennet precipitation, reduced filtration, heat treatment <40°C, freeze-drying) (MF); and bovine colostrum (used as a positive reference group) (BC). Relative to CF, GF, and MF pigs, BC pigs had greater villus heights, lactose digestion, and absorption and lower gut permeability (P < 0.05). MF and BC pigs had greater plasma citrulline concentrations than CF and GF pigs and intestinal interleukin-8 was lower in BC pigs than in the other groups (P < 0.05). MF pigs had lower concentrations of intestinal claudin-4, cleaved caspase-3, and phosphorylated c-Jun than CF pigs (P < 0.05). The conventional and gently treated WPCs had similar efficacy in stimulating proliferation of porcine intestinal epithelial cells. We conclude that processing of WPC affects intestinal structure, function, and integrity when included in formulas for preterm pigs. Optimization of WPC processing technology may be important to preserve the bioactivity and nutritional value of formulas for sensitive newborns.

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“…To determine the intestinal monosaccharide absorptive function after the MEN period, we measured the concentration of plasma Macronutrient composition of bovine colostrum (BC) and bovine milk (BM) was calculated on the basis of a previous study and literature (23,44). Macronutrient composition of reconstituted whole milk powder (WMP) and infant formula (IF) was calculated on the basis of production specifications provided by manufacturers.…”

Section: In Vivo Sugar Digestion and Absorption Testmentioning

confidence: 99%

Raw bovine milk improves gut responses to feeding relative to infant formula in preterm piglets

Jensen

Chatterton

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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Kvistgaard AS, Sangild PT. Raw bovine milk improves gut responses to feeding relative to infant formula in preterm piglets. Am J Physiol Gastrointest Liver Physiol 306: G81-G90, 2014. First published October 24, 2013 doi:10.1152 doi:10. /ajpgi.00255.2013 neonates, the quality of the first milk is crucial for intestinal maturation and resistance to necrotizing enterocolitis (NEC). Among other factors, milk quality is determined by the stage of lactation and processing. We hypothesized that unprocessed mature bovine milk (BM; raw bovine milk) would have less bioactivity than corresponding bovine colostrum (BC) in a preterm pig model, but have improved bioactivity relative to its homogenized, pasteurized, spray-dried equivalent, whole milk powder (WMP), or a bovine milk proteinbased infant formula (IF). For 5 days, newborn preterm pigs received parenteral and enteral nutrition consisting of IF (n ϭ 13), BM (n ϭ 13), or BC (n ϭ 14). In a second study, WMP (n ϭ 15) was compared with IF (n ϭ 10) and BM (n ϭ 9). Compared with pigs fed IF, pigs that were fed BM had significantly improved intestinal structure (mucosal weight, villus height) and function (increased nutrient absorption and enzyme activities, decreased gut permeability, nutrient fermentation, and NEC severity). BC further improved these effects relative to BM (lactase activity, lactose absorption, plasma citrulline, and tissue interleukin-8). WMP induced similar effects as BM, except for lactase activity and lactose absorption. In conclusion, the maturational and protective effects on the immature intestine decreased in the order BCϾBMϾWMP, but all three intact bovine milk diets were markedly better than IF. The stage of lactation (colostrum vs. mature milk) and milk processing (e.g., homogenization, fractionation, pasteurization, spray-drying) are important factors in determining milk quality during the early postnatal period of preterm neonates. colostrum; mature milk; processing; preterm; intestinal maturation PRETERM NEONATES HAVE AN IMMATURE intestine that exhibits compromised nutrient absorption, reduced intestinal barrier function, and suboptimal immune responses toward microbes and food antigens (32). Consequently, preterm infants are very sensitive to enteral feeding and more prone to gastrointestinal complications, the most severe one of which is necrotizing enterocolitis (NEC). Early introduction of enteral feeding is beneficial for intestinal maturation and protection against NEC, but the quality of the diet may critically affect these positive effects. For example, the feeding of mother's milk matures the preterm gut and reduces the risk of NEC relative to bovine milk-based infant formula (IF) and possibly also banked donor milk (22,29,34,39,40). Donor milk (DM) is normally obtained at a relatively late stage of lactation, and therefore may not be appropriate as the first diet, when infants are supposed to receive mother's colostrum. Colostrum is the first milk after parturition (1-3 days) and contains trophic factors and immunoregulatory facto...

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Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome

Cited by 27 publications

References 46 publications

Clinical applications of bovine colostrum therapy: a systematic review

Clinical applications of bovine colostrum therapy: a systematic review

Whey Protein Processing Influences Formula-Induced Gut Maturation in Preterm Pigs

Raw bovine milk improves gut responses to feeding relative to infant formula in preterm piglets

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