Randomised equivalency trial comparing 2.5% povidone-iodine eye drops and ophthalmic chloramphenicol for preventing neonatal conjunctivitis in a trachoma endemic area in southern Mexico

Ramírez‐Ortiz, Marco A.; Rodriguez-Almaraz, M.; Ochoa-Díaz-López, Héctor; Diaz‐Prieto, Paulina; Rodriguez‐Suárez, Romeo S

doi:10.1136/bjo.2007.119867

Cited by 26 publications

(19 citation statements)

References 17 publications

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“…A study in Mexico compared the 2.5% povidone-iodine and the 1% chloramphenicol eye ointment in a Chlamydia-endemic area, but it did not evaluate their efficiency in reducing bacterial colonies in the conjunctiva. 9 For many years, the 1% chloramphenicol eye ointment has been used as a prophylactic agent against ON in many hospitals in Indonesia, including our hospital which is a national referral center in Indonesia. It is necessary to seek alternative prophylactic agents such as povidone-iodine eye solution.…”

mentioning

confidence: 99%

The Efficacy of 1% Chloramphenicol Eye Ointment Versus 2.5% Povidone-Iodine Ophthalmic Solution in Reducing Bacterial Colony in Newborn Conjunctivae

Bramantyo

Roeslani

Andriansjah

et al. 2015

Asia-Pacific Journal of Ophthalmology

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mentioning

confidence: 99%

The Efficacy of 1% Chloramphenicol Eye Ointment Versus 2.5% Povidone-Iodine Ophthalmic Solution in Reducing Bacterial Colony in Newborn Conjunctivae

Bramantyo

Roeslani

Andriansjah

et al. 2015

Asia-Pacific Journal of Ophthalmology

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“…A full description of the cohort has been already published [13]. In brief, a cohort study of 2184 newborns from three public hospitals in Chiapas was started in 2003 [14]. The initial assessment included sociodemographic data, anthropometric measurements of the newborn and gynecological history of the mother.…”

Section: Methodsmentioning

confidence: 99%

Dietary Carbohydrates and Insulin Resistance in Adolescents from Marginalized Areas of Chiapas, México

et al. 2019

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Evidence of the role that dietary carbohydrates (total carbohydrates, dietary fiber, total sugars, dietary glycemic index (GI) and glycemic load (GL)) exerts on insulin levels in adolescents is controversial. Thus, the aim of this study was to assess the association between dietary carbohydrates and insulin resistance in adolescents from Chiapas, México. A cross-sectional study was conducted in 217 adolescents. Sociodemographic, anthropometric, dietary and biochemical data were obtained. Total carbohydrates, dietary fiber, total sugars, dietary GI and GL were calculated from 24 h recalls. Two validated cut-off points for the homeostasis model assessment of insulin resistance (HOMA-IR) were used as surrogates of insulin resistance. Fasting insulin levels ≥ 14.38 μU/mL were considered as abnormal. Multivariate logistic regression models were fitted to assess the association between tertiles of dietary carbohydrates and insulin resistance or hyperinsulinemia. In our study, adolescents with the highest dietary fiber intake had lower odds of HOMA-IR > 2.97 (OR = 0.34; 95% CI: 0.13–0.93) when adjusted for sex, age, body fat percentage and saturated fatty acids intake. No significant associations were found for the rest of the carbohydrate variables. In summary, high-fiber diets reduce the probability of insulin resistance in adolescents from marginalized areas of Chiapas, México.

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“…In Canada, erythromycin has been the only antibiotic eye ointment available for use in neonates since tetracycline ophthalmic ointment became unavailable. Povidone-iodine has been considered for prophylaxis, (12) but this agent may not be effective (13,14) and has been associated with a 5% rate of chemical conjunctivitis. (15) Gentamicin ointment was used for newborn ocular prophylaxis during a shortage of erythromycin ointment in the United States in 2009, but resulted in reports of severe ocular reactions.…”

Section: La Prévention De La Conjonctivite Néonatalementioning

confidence: 99%

Preventing Ophthalmia Neonatorum

Moore

MacDonald

2015

Canadian Journal of Infectious Diseases and Medical Microbiolog

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The use of silver nitrate as prophylaxis for neonatal ophthalmia was instituted in the late 1800s to prevent the devastating effects of neonatal ocular infection withNeisseria gonorrhoeae. At that time – during the preantibiotic era – many countries made such prophylaxis mandatory by law. Today, neonatal gonococcal ophthalmia is rare in Canada, but ocular prophylaxis for this condition remains mandatory in some provinces/ territories. Silver nitrate drops are no longer available and erythromycin, the only ophthalmic antibiotic eye ointment currently available for use in newborns, is of questionable efficacy. Ocular prophylaxis is not effective in preventing chlamydial conjunctivitis. Applying medication to the eyes of newborns may result in mild eye irritation and has been perceived by some parents as interfering with mother-infant bonding. Physicians caring for newborns should advocate for rescinding mandatory ocular prophylaxis laws. More effective means of preventing ophthalmia neonatorum include screening all pregnant women for gonorrhea and chlamydia infection, and treatment and follow-up of those found to be infected. Mothers who were not screened should be tested at delivery. Infants of mothers with untreated gonococcal infection at delivery should receive ceftriaxone. Infants exposed to chlamydia at delivery should be followed closely for signs of infection.

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Randomised equivalency trial comparing 2.5% povidone-iodine eye drops and ophthalmic chloramphenicol for preventing neonatal conjunctivitis in a trachoma endemic area in southern Mexico

Abstract: PIED seems to increase the risk of acquiring chlamydial conjunctivitis in neonates. Additional measures are required to prevent mother to fetus transmission of chlamydial infection during pregnancy, delivery, and after birth.

Cited by 26 publications

References 17 publications

The Efficacy of 1% Chloramphenicol Eye Ointment Versus 2.5% Povidone-Iodine Ophthalmic Solution in Reducing Bacterial Colony in Newborn Conjunctivae

The Efficacy of 1% Chloramphenicol Eye Ointment Versus 2.5% Povidone-Iodine Ophthalmic Solution in Reducing Bacterial Colony in Newborn Conjunctivae

Dietary Carbohydrates and Insulin Resistance in Adolescents from Marginalized Areas of Chiapas, México

Preventing Ophthalmia Neonatorum

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