Randomized clinical trial comparing the efficacy of the vaginal use of metronidazole with a Brazilian pepper tree (Schinus) extract for the treatment of bacterial vaginosis

Leite, S.R.R.F.; Amorim, Melânia Maria Ramos; Sereno, Pedro; Leite, T.N.F.; Ferreira, J. Arjona; Ximenes, Ricardo A. A.

doi:10.1590/s0100-879x2011007500003

Cited by 20 publications

(18 citation statements)

References 21 publications

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“…A subsequent study compared the effect of a gel containing 7.4% of S. terebinthifolius extract with a 0.75% metronidazole gel for the treatment of bacterial vaginosis using two groups of 140 and 137 women, aged between 18 and 40 years. The cure rate for bacterial vaginosis using S. terebinthifolius gel was significantly lower than that obtained with metronidazole gel, while side effects were infrequent and non-severe in both groups (Leite et al, 2011).…”

Section: Biological Propertiesmentioning

confidence: 63%

Schinus terebinthifolius Raddi: chemical composition, biological properties and toxicity

Carvalho

Melo

Aragão

et al. 2013

Rev. bras. plantas med.

105

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RESUMO: Schinus terebinthifolius Raddi: Composição química, propriedades biológicas, e toxicidade. Schinus terebinthifolius Raddi é uma planta medicinal conhecida no Brasil como "aroeira da praia", utilizada na medicina popular como antitérmica, analgésica, depurativa e no tratamento de doenças do sistema urogenital. Por outro lado, a literatura científica relata que essa planta apresenta atividade antimicrobiana, anti-inflamatória, e antiulcerogênica. Essa revisão trata das principais propriedades biológicas e efeitos toxicológicos da aroeira da praia, além de uma abordagem sistemática acerca dos compostos que já foram encontrados nessa espécie, estando a maioria deles presente nos óleos essenciais.Palavras Chave: Schinus terebinthifolius, Anacardiaceae, componentes químicos, propriedades biológicas. ABSTRACT: Schinus terebinthifoliusRaddi is a medicinal plant known in Brazil as "aroeira da praia", which has been used in popular medicine as antipyretic, analgesic, depurative and in the treatment of diseases of the urogenital system. On the other hand, the scientific literature has reported that this plant has antimicrobial, anti-inflammatory and antiulcerogenic activity. This review addresses the main biological properties and toxicological effects of "aroeira da praia", in addition to a systematic approach of the compounds that were already found in this species, the great majority of which is present in the essential oils.

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Section: Biological Propertiesmentioning

confidence: 63%

Schinus terebinthifolius Raddi: chemical composition, biological properties and toxicity

Carvalho

Melo

Aragão

et al. 2013

Rev. bras. plantas med.

105

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“…The reason that influenced its choice was easy extraction, preparation, drying, grinding, storage and application 21 , and also because its current use as medicine herbal, though without scientific confirmation 8,16 . Preclinical studies in mice showed that the extract of babassu mesocarp had beneficial effect on several circumstances 22 .…”

Section: Herbal Choice and Route Of Administrationmentioning

confidence: 99%

Schinus terebinthifolius raddi (Aroeira) and Orbignya phalerata mart. (Babassu) effect in cecorrahphy healing in rats

et al. 2016

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METHODS:Fifty four rats were used, distributed into three groups randomly: aroeira, babassu and control, which were divided into three subgroups (six animals) according to the time of the deaths (7, 14, 21 days). All underwent the same surgical procedure, cecotomy and cecorrhaphy. The animals in group aroeira and babassu received daily dose of 100 mg/kg of hydroalcoholic extract and 50 mg/kg of aquous extract respectively, by gavage. The control group received only saline solution. The parameters evaluated were: macroscopic changes, ,resistance test to air insufflations and histological changes. RESULTS:All animals showed good healing without infection. All groups presented adhesions between cecum and neighboring organs.The resistance test insufflating of atmospheric air showed progressive increase of pressure according to the days in the aroeira group, and decrease in babassu group, without significant difference. Microscopy showed significant difference in the polymorphonuclear, hyperemia, angiogenesis, fibroblast proliferation and collagen histological variables in the 14 th day. CONCLUSION:Hydroalcoholic extract of aroeira and the aqueous extract of babassu favored the healing process in cecorrhaphy in rats.

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“…However, a clinical trial conducted by Leite et al . () showed that the efficacy of S. terebinthifolius was significantly lower than metronidazole for the treatment of bacterial infections.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Toxicity of the Brazilian Pepper Trees Schinus terebinthifolius Raddi (Aroeira‐da‐praia) and Myracrodruon urundeuva Allemão (Aroeira‐do‐sertão)

Carlini

Duarte-Almeida

Tabach

2012

Phytotherapy Research

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The present study aimed to assess the preclinical toxicity of two plants commonly used to treat "stomach ailments" in Brazil: Schinus terebinthifolius Raddi (S) and Myracrodruon urundeuva Allemão (M). In male rats, chronic treatment (83 days) with both pepper trees (17.6 and 13.8 mg/kg, S and M, respectively) has been shown to decrease hematocrit. However, a reduction in the number of red blood cells and hemoglobin was only seen following administration of S. terebinthifolius. None of the plants caused anatomopathological alterations following chronic treatment, and mating ability and fertility were not affected. Both pepper trees showed moderate toxicity following acute and chronic treatment by gavage, particularly S. terebinthifolius. Moreover, bone malformations were induced in fetuses, and a slight delay in recovery time of the postural reflex was observed in pups from female animals treated (18 days) with S. terebinthifolius. Given these results, a better assessment of the risks and benefits of the internal use of these plants is necessary, especially when used by women of childbearing age.

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Randomized clinical trial comparing the efficacy of the vaginal use of metronidazole with a Brazilian pepper tree (Schinus) extract for the treatment of bacterial vaginosis

Cited by 20 publications

References 21 publications

Schinus terebinthifolius Raddi: chemical composition, biological properties and toxicity

Schinus terebinthifolius Raddi: chemical composition, biological properties and toxicity

Schinus terebinthifolius raddi (Aroeira) and Orbignya phalerata mart. (Babassu) effect in cecorrahphy healing in rats

Assessment of the Toxicity of the Brazilian Pepper Trees Schinus terebinthifolius Raddi (Aroeira‐da‐praia) and Myracrodruon urundeuva Allemão (Aroeira‐do‐sertão)

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