Randomized clinical trial: efficacy and tolerability of two different split dose of low-volume polyethylene glycol electrolytes for bowel preparation before colonoscopy in hospitalized children

Fang, Shengbo; Song, Yanqing; Liu, Yuanyuan; Wang, Libo

doi:10.1038/s41390-020-01216-5

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…After taking the medicine, the bowel cleanliness is high, which will not increase the pain of patients. The patient's compliance is high and the psychological state is good [ 24 , 25 ]. The results of this study showed that the effective rate of bowel cleaning in the observation group was significantly higher than that in the control group ( P < 0.05), and the frequency of defecation and duration of diarrhea in the observation group were significantly lower than those in the control group ( P < 0.05), which suggested that PGEP had a rapid and effective role in bowel preparation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Compound Polyethylene Glycol Electrolyte Powder on the Quality of Gastrobowel Preparation before Enteroscopy Intervention

Yuan

Zhang

et al. 2022

Emergency Medicine International

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Objective. To study the effect of compound polyethylene glycol electrolyte powder (PGEP) on the quality of gastrobowel preparation before enteroscopy intervention. Methods. From March 2021 to January 2022, among the patients who needed enteroscopy in our hospital, 280 patients who volunteered for this study were randomly selected as the research objects. All the subjects were randomly divided into the control group (140 cases) and the observation group (140 cases). Both groups received routine treatment before enteroscopy intervention. On this basis, patients in the control group were given 9 g of senna every day before operation, and 250 ml of 20% mannitol and 2500 ml of water were taken orally from 9:00 am to 11:00 am on the day of examination. Patients in the observation group took PGEP orally from 9:00 am to 11:00 am. The effective rate of bowel cleaning, the frequency of defecation and duration of diarrhea, the levels of blood electrolyte indexes such as Na+, K+, and Cl− before and after the intervention, and the incidence of adverse reactions were compared between the two groups. Results. The effective rate of bowel cleaning in the observation group was significantly higher than that in the control group ( P < 0.05 ). The frequency of defecation and duration of diarrhea in the observation group were significantly lower than those in the control group ( P < 0.05 ). Compared with the control group, the levels of blood electrolyte indexes in the observation group after the intervention were not statistically significant ( P > 0.05 ). The incidence of adverse reactions in the observation group was significantly lower than that in the control group ( P < 0.05 ). Conclusion. Using PGEP for gastrobowel preparation before enteroscopy intervention can achieve high bowel cleaning efficiency, short bowel preparation time, and low incidence of adverse reactions, which does not affect the water-electrolyte balance of patients, and the psychological state of patients before enteroscopy intervention is more stable. This program is worthy of clinical promotion.

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Section: Discussionmentioning

confidence: 99%

Effect of Compound Polyethylene Glycol Electrolyte Powder on the Quality of Gastrobowel Preparation before Enteroscopy Intervention

Yuan

Zhang

et al. 2022

Emergency Medicine International

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“…Laxatives are an alternative option for 'getting rid of' recipient gut microbiota, and are gaining more and more popularity in human FMT treatments considering that antibiotic treatment has the potential risk of causing multidrug resistance, which is also one of the major concerns and limitations for wider FMT implementations in clinical practices. A study showed that 40 mL/kg of polyethylene glycol (PEG 4000) provides efficient bowel cleaning in human subjects [80]. Another recent study reported that 425 g/L of PEG administered by oral gastric gavages at 20 min intervals can empty the intestine and decrease the gut microbiota by 90% after four successive administrations in mice [81].…”

Section: Future Perspective Of Canine Fmtmentioning

confidence: 99%

Canine Fecal Microbiota Transplantation: Current Application and Possible Mechanisms

Tuniyazi

et al. 2022

Veterinary Sciences

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Fecal microbiota transplantation (FMT) is an emerging therapeutic option for a variety of diseases, and is characterized as the transfer of fecal microorganisms from a healthy donor into the intestinal tract of a diseased recipient. In human clinics, FMT has been used for treating diseases for decades, with promising results. In recent years, veterinary specialists adapted FMT in canine patients; however, compared to humans, canine FMT is more inclined towards research purposes than practical applications in most cases, due to safety concerns. Therefore, in order to facilitate the application of fecal transplant therapy in dogs, in this paper, we review recent applications of FMT in canine clinical treatments, as well as possible mechanisms that are involved in the process of the therapeutic effect of FMT. More research is needed to explore more effective and safer approaches for conducting FMT in dogs.

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“…In our opinion, a split-dose regimen would help to solve this problem and improve tolerability. Two studies conducted in Asia have demonstrated that split-dose regimens (half the dose given the day before colonoscopy between 18:00 and 20:00, and half the dose given the day of colonoscopy between 06:00 and 08:00) for bowel cleansing are both effective and well tolerated ( 5 , 6 ); however, in most European centers, adherence to fasting times for deep sedation or general anesthesia in pediatrics does not allow colonoscopy on the same day as oral bowel cleansing.…”

Section: Discussionmentioning

confidence: 99%

“…E ffective bowel cleansing before colonoscopy is crucial to allow complete visualization of the colonic mucosa (1). Several protocols and cleansing preparations are used as there are few randomized trials to guide recommendations in children (2)(3)(4)(5)(6)(7). In addition, bowel cleansing solutions in children are limited by acceptance and safety issues.…”

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confidence: 99%

Phase III Randomized Non-Inferiority Study of OSS Versus PEG + Electrolyte Colonoscopy Preparation in Adolescents

Socha

Posovszky

Szychta

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objectives: Many protocols and preparations are used for bowel cleansing before pediatric colonoscopy but few are based on scientific evidence. We evaluated efficacy, safety, tolerability, and patient preference of oral sulfate solution (OSS) at 75% of the adult dose versus polyethylene glycol (PEG)-electrolyte solution in adolescents presenting for diagnostic colonoscopy. Methods: Phase III, randomized, evaluator-blinded, non-inferiority study of OSS and PEG in adolescents aged 12–17 years. OSS and PEG were administered in 2 doses on the day before colonoscopy. Primary endpoint included proportion of patients with successful overall preparation (4-point scale). Secondary endpoints included overall and segmental bowel cleansing (Boston Bowel Preparation Scale; BBPS), completed colonoscopies, duration of examination, time to cecal intubation, proportion of nasogastric tubes (NGTs), adverse events (AEs) and acceptability. Results: Successful cleansing was achieved in 71.4% and 79.0% of patients receiving OSS and PEG, respectively [adjusted difference −7.61 (95% confidence interval, CI, −18.45 to 3.24); P = 0.0907]. Segmental BBPS score for the left and transverse colon were similar between treatment groups, but better for the right colon with PEG than OSS [2.2 (95% CI, 2.0–2.4) and 1.9 (95% CI, 1.7–2.1), respectively; P = 0.0015]. Significantly fewer OSS patients needed NGT placement to ingest the whole solution [9/125 (7.2%)] than PEG patients [36/116 (31.0%); P < 0.0001]. Treatment acceptability was significantly higher with OSS than PEG ( P < 0.0001). Duration of examination, completed colonoscopies, and time to cecal intubation were similar between preparations. Gastrointestinal AEs including nausea, vomiting, abdominal pain, and distension were similar in both groups but more patients receiving PEG had AEs assessed as incapacitating. Conclusions: Non-inferiority of OSS to PEG was not demonstrated, but OSS was associated with a lower requirement for NGT, better acceptability, and less frequent severe AEs than with PEG.

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Randomized clinical trial: efficacy and tolerability of two different split dose of low-volume polyethylene glycol electrolytes for bowel preparation before colonoscopy in hospitalized children

Cited by 7 publications

References 19 publications

Effect of Compound Polyethylene Glycol Electrolyte Powder on the Quality of Gastrobowel Preparation before Enteroscopy Intervention

Effect of Compound Polyethylene Glycol Electrolyte Powder on the Quality of Gastrobowel Preparation before Enteroscopy Intervention

Canine Fecal Microbiota Transplantation: Current Application and Possible Mechanisms

Phase III Randomized Non-Inferiority Study of OSS Versus PEG + Electrolyte Colonoscopy Preparation in Adolescents

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