Randomized Comparison of Mohs Micrographic Surgery and Surgical Excision for Small Nodular Basal Cell Carcinoma

Muller, F. M.; Dawe, Robert; Moseley, Harry; Fleming, Colin

doi:10.1111/j.1524-4725.2009.01240.x

Cited by 87 publications

(66 citation statements)

References 11 publications

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“…This process is continued in a repeating fashion until the tissue section(s) show no histologic evidence of residual tumour. 45 The process can be time-consuming, requires specialized training, and although it can be cost-effective, is still costly. MMS results in cure rates as high as 99% and 96% for primary and recurrent tumours, respectively.…”

Section: Mohs Micrographic Surgerymentioning

confidence: 99%

Non-melanoma Skin Cancer in Canada Chapter 4: Management of Basal Cell Carcinoma

et al. 2015

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Background: Basal cell carcinoma (BCC) is the most common malignancy. Growth of BCCs leads to local destruction of neighbouring healthy skin and underlying tissue and can result in significant functional and cosmetic morbidity. Objective: To provide guidance to Canadian health care practitioners regarding management of BCCs. Methods: Literature searches and development of graded recommendations were carried out as discussed in the accompanying Introduction. Results: Although BCCs rarely metastasize, they can be aggressive and disfiguring. This chapter describes the natural history and prognosis of BCCs. Risk stratification is based on clinical features, including the site and size of the tumour, its histologic subtype (nodular vs sclerosing), and its history of recurrence. Conclusions: Various options should be considered for BCC treatment, including cryosurgery, curettage, and topical or photodynamic approaches, as well as fixed-margin surgery and Mohs micrographic surgery. Stratification of recurrence risk for individual BCCs determines the most appropriate therapeutic course. RésuméContexte : Le carcinome basocellulaire (CBC) est le cancer le plus répandu. La croissance d'un CBC mène à la destruction locale de la peau saine environnante et des tissus sous-jacents et peut causer une morbidité fonctionnelle et cosmétique importante. Objectif : Fournir des conseils aux professionnels canadiens de la santé au sujet de la gestion des CBC. Méthode : Nous avons procédé à une étude documentaire et à l'élaboration de catégories de recommandations, comme on peut le lire dans l'introduction connexe. Résultats : Le CBC forme rarement des métastases, mais il peut être agressif et défigurant. Ce chapitre décrit l'évolution et le pronostic du CBC. La stratification du risque est fondée sur les caractéristiques cliniques, y compris l'emplacement et la taille de la tumeur, et son sous-type histologique (nodulaire ou sclérosant), et sur les antécédents de récurrence. Conclusion : Diverses options devraient être envisagées dans le traitement du CBC, y compris la cryochirurgie, le curetage et les approches topiques ou photodynamiques, ainsi que la chirurgie à marge déterminée et la chirurgie micrographique de Mohs. La stratification du risque de récurrence de chaque CBC individuel détermine le traitement thérapeutique le plus approprié.

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Section: Mohs Micrographic Surgerymentioning

confidence: 99%

Non-melanoma Skin Cancer in Canada Chapter 4: Management of Basal Cell Carcinoma

et al. 2015

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“…In a small randomized trial, Muller et al reported that defect size after MMS for nodular BCC was significantly smaller (P \.001) than after standard excision (116.6 vs 187.7 mm 2 ). 50 Smeets et al reported that for tumors requiring more than 1 standard excision, or at least 2 stages of MMS, defects after excision were significantly larger than after MMS for primary and recurrent BCC. 33 Although smaller defects did not lead to significant differences in aesthetic outcome between MMS and standard excision in RCTs, both surgical modalities were found to be superior to C&E with regard to quality of life outcomes.…”

Section: Standard Excisionmentioning

confidence: 99%

Guidelines of care for the management of basal cell carcinoma

Baum¹,

Bordeaux²,

Brown³

et al. 2018

Journal of the American Academy of Dermatology

328

219

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Basal cell carcinoma (BCC) is the most common form of human cancer, with a continually increasing annual incidence in the United States. When diagnosed early, the majority of BCCs are readily treated with office-based therapy, which is highly curative. In these evidence-based guidelines of care, we provide recommendations for the management of patients with BCC, as well as an in-depth review of the best available literature in support of these recommendations. We discuss biopsy techniques for a clinically suspicious lesion and offer recommendations for the histopathologic interpretation of BCC. In the absence of a formal staging system, the best available stratification based on risk for recurrence is reviewed. With regard to treatment, we provide recommendations on treatment modalities along a broad therapeutic spectrum, ranging from topical agents and superficially destructive modalities to surgical techniques and systemic therapy. Finally, we review the available literature and provide recommendations on prevention and the most appropriate follow-up for patients in whom BCC has been diagnosed. ( J Am Acad Dermatol

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“…Man ender som regel opp med en mindre huddefekt enn etter vanlig eksisjon -dermed kan man anvende enklere rekonstruksjonsmetoder (19,21). Huddefekten lukkes med primaersutur eller tilheler sekundaert.…”

Section: Mohs' Kirurgiunclassified

“…Ved at tumorutløperne forfølges trinnvis, oppnås radikalitet i tilnaermet alle tilfellene, samtidig som man sparer friskt vev. Huddefekten er som regel mindre enn etter vanlig eksisjon, og enklere rekonstruksjonsløsnin-ger kan velges (19,21).…”

Section: Vevssparendeunclassified

Mohs' kirurgi ved basalcellekarsinom i ansiktet

Roscher¹,

Brevig²,

Mørk³

et al. 2011

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Randomized Comparison of Mohs Micrographic Surgery and Surgical Excision for Small Nodular Basal Cell Carcinoma

Abstract: http://www.clinicaltrials.gov Identifier: NCT00571363. The authors have indicated no significant interest with commercial supporters.

Cited by 87 publications

References 11 publications

Non-melanoma Skin Cancer in Canada Chapter 4: Management of Basal Cell Carcinoma

Non-melanoma Skin Cancer in Canada Chapter 4: Management of Basal Cell Carcinoma

Guidelines of care for the management of basal cell carcinoma

Mohs' kirurgi ved basalcellekarsinom i ansiktet

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