Randomized controlled clinical trial on the efficacy of dentin desensitizing agents

Mehta, Dhoom Singh; Gowda, Vishwas; Santosh, Ashwini; Finger, Werner J.; Sasaki, Keiichi

doi:10.3109/00016357.2014.923112

Cited by 47 publications

(62 citation statements)

References 24 publications

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“…As in the present investigation, many studies have shown that treatment with desensitizing agents decreases hypersensitivity over time [1][2][3][4]6,7,12,15,19,22 . The acting speed of the materials used for DH treatment is an important factor to be considered.…”

Section: Discussionsupporting

confidence: 68%

“…DH etiology is due to dentin tubule exposure, manifesting as short, acute pain, and caused by thermal, chemical, and osmotic stimuli [1][2][3][4] . There are several proposed treatments, showing effectiveness in different degrees and times, but a permanent solution is not complete.…”

Section: Discussionmentioning

confidence: 99%

“…It is clinically the result of dentin exposure and is characterized by acute, short and temporary pain in response to mechanical, chemical, thermal, or osmotic stimuli and cannot be attributed to any other dental pathology [1][2][3][4] . The most widely accepted theory to explain DH is Brännström's hydrodynamic theory 5 and one of its main causes is non-carious cervical lesions such as abrasion, erosion, and abfraction 6 .…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of a bioactive material and nanostructured desensitizing on dentin hypersensitivity treatment

Bevilacqua

Catelan

Araújo

et al. 2016

Rev. odontol. UNESP

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ResumoIntrodução: A hipersensibilidade dentinária é uma ocorrência frequente na prática clínica; clinicamente caracterizada por dor aguda, curta e temporária, em resposta ao estímulo mecânico, químico, térmico ou osmótico causada pela exposição dentinária. Objetivo: Comparar in vivo o efeito de um material bioativo cristalino experimental e um dessensibilizante nanoestruturado na avaliação da dor de pacientes com hipersensibilidade dentinária cervical. Material e método: Trinta pacientes foram selecionados para este estudo, que foram randomicamente divididos em dois grupos (n=15) em um desenho experimental de boca dividida. Cada paciente recebeu dois tratamentos: grupo 1 (flúor gel e material bioativo) e grupo 2 (flúor gel e dessensibilizante nanoestruturado). As análises de dor foram realizadas usando uma escala visual analógica, variando de 0-10. A mensuração da dor inicial foi realizada previamente ao tratamento inicial (T 0 ) e novas análises foram realizadas semanalmente durante 3 semanas (T 1 , T 2 e T 3 ) antes da reaplicação dos materiais. A análise final da dor foi realizada 3 meses após o início do tratamento (T 4 ). O grau de redução de dor foi mensurado pela fórmula: T 0 -T período após tratamento . Os dados das mensurações de dor foram analisados pela ANOVA para medidas repetidas 2 critérios e teste de Tukey (α=0,05). Resultado: Independente do período de avaliação, não houve diferença estatística entre todos os tratamentos na redução da dor (p>0,05). O grau de dor reduziu significativamente em cada período avaliado para todos os tratamentos testados (p<0,05), aproximadamente três graus após 3 meses. Conclusão: Os materiais dessensibilizantes testados foram efetivos na redução da hipersensibilidade dentinária.Descritores: Dessensibilizantes dentinários; sensibilidade da dentina; dor. AbstractIntroduction: Dentin hypersensitivity is a frequent occurrence in dental practice. It is clinically characterized by acute, short, and temporary pain in response to mechanical, chemical, thermal, or osmotic stimuli resulting from dentin exposure. Objective: To compare in vivo the effect of an experimental crystalline bioactive material and nanostructured desensitizing on the pain assessment among patients with cervical dentin hypersensitivity. Material and method: Thirty patients were selected for this study, who were randomly assigned to two groups (n=15) in a split-mouth design. Each patient received two treatments: group 1 (fluoride gel and bioactive material) and group 2 (fluoride gel and nanostructured desensitizing). Pain analyses were performed using a visual analogue scale, ranging 0-10. Baseline pain measurement was performed prior to initial treatment (T 0 ) and new measurements were carried out weekly for 3 weeks (T 1 , T 2 , and T 3 ) before materials were reapplied. Final pain analysis was performed 3 months after initial treatment (T 4 ). Degree of pain reduction was calculated using the formula T 0 -T period after treatment . The data of the pain measurements were analyzed using 2-way repeated mea...

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of a bioactive material and nanostructured desensitizing on dentin hypersensitivity treatment

Bevilacqua

Catelan

Araújo

et al. 2016

Rev. odontol. UNESP

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“…Sample size estimation was based on findings from a previous study 21 that showed a minimum significant difference of 1 in VAS. With a total of 45 patients entering this crossover repeated measures, the probability is 80% that the study will detect a treatment difference at a two-sided 0.05 significance level if the true difference in VAS scores between the treatments is 0.5, assuming that within-patient standard deviation of the response is 0.7.…”

Section: Methodsmentioning

confidence: 99%

“…So far, there are only two clinical reports published in international literature that underline the potential of these compounds as reasonably effective desensitizing agents. 21,22 In a previous study, the paste product (TAP; Kuraray Noritake, Dental Inc., Okayama, Japan) was applied for 30 seconds with a rotating rubber cup at 1,000 rpm according to the primary instructions of the manufacturer and compared with distilled water as placebo, applied with a microbrush. 22 In this study, a possible overlying burnishing effect on dentin, caused by the rubber cup application, might have confounded the effect of the calcium phosphate compound's desensitizing action.…”

Section: Introductionmentioning

confidence: 99%

A Novel Desensitizer Paste containing Calcium Phosphate: Randomized, Placebo-controlled, Double-blinded and 6 Months Trial

Moogi

Rupesh

Mehta

et al. 2017

World Journal of Dentistry

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Aim: This study aims to investigate the effect of a calcium phosphate-based desensitizer paste on reduction of dentin hypersensitivity (DH). Materials and methods:This crossover study was designed as randomized, double-blinded, and placebo-controlled trial. Teethmate AP paste (TAP), containing tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) dispersed in a glycerol/polyethylene glycol paste, was compared with placebo (PLA), a calcium phosphate-free analog paste. A total of 45 patients with one hypersensitive cervical lesion in each of two contralateral quadrants were allocated to the trial when baseline sensitivity (pretreatment sensitivity score, PRE) on air-blast (AB) stimulation and probe scratching (PS) measured on a visual analog scale (VAS; 0-10) was ≥6. Patients were recalled after 1 day, 1 week, and 1, 3, and 6 months. One-way analysis of variance (ANOVA), Tukey's post hoc test, and pairwise comparisons between TAP and PLA were conducted at all time points (α < 0.05).Results: Both treatments reduced DH significantly during the 6-month course. Immediately after treatment (posttreatment sensitivity score, POST), TAP sensitivity on AB was reduced to 63%, after 6 months to 39% of the PRE score, and PS to 60 and 54% respectively. Application of PLA reduced AB sensitivity at POST and 6 months to 79 and 60%, and on PS stimulation to 79 and 67% respectively. At all time points, TAP and PLA were significantly different (p < 0.05). Conclusion:Teethmate AP paste is a biocompatible and effective desensitizing agent when used for the treatment of moderately severe DH.Clinical significance: Calcium phosphate-based desensitizers are one of the most effective desensitizing agents and are expected to play an important role in the treatment of DH.

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Bioactive glass plus laser phototherapy as promise candidates for dentine hypersensitivity treatment

et al. 2015

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Treatments for dentine hypersensitivity (DH) may produce positive effects, though do not have lasting results. We investigated the reparative potential of stem cells derived from deciduous teeth (SHEDs) in response to components delivered from substances used in the treatment of the DH, associated or not to laser phototherapy (LPT), to stimulate dentine formation. SHEDs were submitted to substances delivered from a laboratorial P-rich bioactive glass [57SiO -26CaO-17P O (wt %)] or a commercially available desensitizer (Gluma® Desensitizer), associated (or not) to LPT (InGAlP diode laser, 660 nm, 0.028 cm , 20 mW, 5 J/cm , 7 s, contact mode). Biomaterial characterization was performed by X-ray diffraction, scanning electron microscopy and the particle size was evaluated by dynamic light scattering. SHEDs proliferation and differentiation were analyzed by MTT and Alizarin Red staining, respectively. The conditioned media used in these tests were evaluated regarding their pH and the ionic concentration changes due to ions leached from the bioactive glass (BG). BG majority presented a non-crystalline solid structure and mixed particle sizes characterized by the agglomeration of nanoparticles. Cultures treated with BG alone or in association to LPT showed improved cell growth in relation to Gluma (p < 0.05). Gluma was cytotoxic in all tested conditions, regardless irradiated or not. BG associated to LPT induced intense mineral matrix formation. In conclusion, BG releases ionic dissolution products able to promote SHEDs differentiation. BG associated to LPT improves SHEDs proliferation and differentiation in vitro, and may be a promise therapeutic approach for the DH treatment. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 107-116, 2017.

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Randomized controlled clinical trial on the efficacy of dentin desensitizing agents

Abstract: The calcium phosphate-based TMD and GLU proved highly effective in reducing sensitivity.

Cited by 47 publications

References 24 publications

Efficacy of a bioactive material and nanostructured desensitizing on dentin hypersensitivity treatment

Efficacy of a bioactive material and nanostructured desensitizing on dentin hypersensitivity treatment

A Novel Desensitizer Paste containing Calcium Phosphate: Randomized, Placebo-controlled, Double-blinded and 6 Months Trial

Bioactive glass plus laser phototherapy as promise candidates for dentine hypersensitivity treatment

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