Randomized Controlled Trial of Exercise Training in Postmenopausal Breast Cancer Survivors: Cardiopulmonary and Quality of Life Outcomes

Courneya, Kerry S.; Mackey, John R.; Bell, Gordon J.; Jones, Lee W.; Field, Catherine J.; Fairey, Adrian

doi:10.1200/jco.2003.04.093

Cited by 664 publications

(671 citation statements)

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“…Quality of life is a multidimensional construct including physical and psychosocial dimensions [1]. Studies on the effect of physical training in cancer survivors suggest that physical training is primarily associated with improved physical and functional aspects of quality of life, rather than the social and emotional domains [7,8,14]. A recent meta-analysis reported that cognitive-behavioral therapy had positive effects on mental health of cancer survivors [26].…”

Section: Introductionmentioning

confidence: 99%

Long-term effects on cancer survivors’ quality of life of physical training versus physical training combined with cognitive-behavioral therapy: results from a randomized trial

May

Korstjens

Weert

et al. 2008

Support Care Cancer

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Background We compared the effect of a 12-week groupbased multidisciplinary self-management rehabilitation program, combining physical training (twice weekly) and cognitive-behavioral therapy (once weekly) with the effect of 12-week group-based physical training (twice weekly) on cancer survivors' quality of life over a 1-year period. Materials and methods One hundred forty-seven survivors [48.8±10.9 years (mean±SD), all cancer types, medical treatment ≥3 months ago] were randomly assigned to either physical training (PT, n=71) or to physical training plus cognitive-behavioral therapy (PT+CBT, n=76). Quality of life and physical activity levels were measured before and immediately after the intervention and at 3-and 9-month post-intervention using the European Organization forResearch and Treatment of Cancer Quality of Life Questionnaire C30 questionnaire and the Physical Activity Scale for the Elderly, respectively. Results Multilevel linear mixed-effects models revealed no differential pattern in change of quality of life and physical activity between PT and PT+CBT. In both PT and PT+ CBT, quality of life and physical activity were significantly and clinically relevantly improved immediately following the intervention and also at 3-and 9-month post-intervention compared to pre-intervention (p<0.001). Conclusion Self-management physical training had substantial and durable positive effects on cancer survivors' quality of life. Participants maintained physical activity levels once the program was completed. Combining physical training with our cognitive-behavioral intervention Support Care Cancer (2009) did not add to these beneficial effects of physical training neither in the short-term nor in the long-term. Physical training should be implemented within the framework of standard care for cancer survivors.

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Section: Introductionmentioning

confidence: 99%

Long-term effects on cancer survivors’ quality of life of physical training versus physical training combined with cognitive-behavioral therapy: results from a randomized trial

May

Korstjens

Weert

et al. 2008

Support Care Cancer

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“…Several of these programs were offered to individuals in group format and these reported improvement in quality of life, physical functioning and fatigue in cancer patients during primary treatment [3][4][5][6][7][8][9][10] and after completion of initial treatment [11][12][13][14]. Recently, interest has been growing in patients' experience with training within groups.…”

Section: Introductionmentioning

confidence: 99%

The effect of group cohesion on rehabilitation outcome in cancer survivors

et al. 2007

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The effect of group cohesion on rehabilitation outcome in cancer survivors May, Anne M.; Duivenvoorden, Hugo J.; Korstjens, Irene; van Weert, Ellen; HoekstraWeebers, Josette E. H. M.; van den Borne, Bart; Mesters, Ilse; van der Schans, Cees P.; Ros, Wynand J. G. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. AbstractObjective: Group-based physical training interventions have been shown to be effective in increasing quality of life in cancer survivors. Until now, however, the impact of cohesion within the group on intervention outcome has not been investigated.Methods: We examined self-reported individual group cohesion ratings collected in the first half of a 12-week rehabilitation programme for cancer survivors ðN ¼ 132Þ: Four dimensions of group cohesion were measured, i.e. the bond with the group as whole, the bond with other members, cooperation within the group and the instrumental value. Quality of life, physical functioning and fatigue were assessed before and after the intervention using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30. Linear multiple multivariate regression analysis was conducted to explore the relationship between group cohesion and intervention outcome.Results: The relationship between group cohesion and outcome was significantly modified by gender. Higher ratings of cooperation within the group predicted better post-intervention quality of life and physical functioning and less fatigue in men, and better quality of life and physical functioning in women. Additionally, women who reported a stronger bond with other members showed a lower quality of life after the intervention. No relationship was found between the instrumental value and the outcome variables.Conclusion: Some dimensions of group cohesion seem to be associated with intervention outcome. The underlying mechanisms need to be unravelled.

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“…Two studies investigated the effect of exercise in cancer survivors. Both studies used fatigue as a secondary outcome and showed beneficial effects (Courneya et al, 2003;Pinto et al, 2005). The fifth study found that acupuncture was a more effective method to improve fatigue compared with acupressure or sham acupressure (Molassiotis et al, in press).…”

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confidence: 99%

Cognitive behaviour therapy for fatigued cancer survivors: long-term follow-up

2007

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An earlier randomised-controlled trial demonstrated the positive effects of cognitive behaviour therapy (CBT), especially designed for fatigued cancer survivors in reducing fatigue, functional impairments and psychological distress. In the current prospective study, we were able to examine the long-term effect of CBT in patients who completed the therapy. Predictors of fatigue severity at follow-up were exploratory investigated. Sixty-eight patients who completed CBT were assessed at pretreatment, post-treatment and at follow-up (mean follow-up 1.9 years (s.d. 1.0), range: 1 -4 years). To analyse possible predictors of treatment outcome a linear regression (enter) was carried out. Improvements on fatigue severity, functional impairment and psychological distress after CBT appeared to remain stable during a follow-up period. Patients who were not fatigued anymore at follow-up were not different from a reference group of non-fatigued cancer survivors. The explorative regression analysis showed that fatigue severity, psychological distress and somatic attributions at pretreatment contributed to persistent fatigue severity at follow-up. Cognitive behaviour therapy, especially designed for post-cancer fatigue, is successful in reducing fatigue and functional impairment in cancer survivors. Moreover, these positive effects were maintained at about 2 years after finishing CBT.

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Randomized Controlled Trial of Exercise Training in Postmenopausal Breast Cancer Survivors: Cardiopulmonary and Quality of Life Outcomes

Abstract: Exercise training had beneficial effects on cardiopulmonary function and QOL in postmenopausal breast cancer survivors.

Cited by 664 publications

References 35 publications

Long-term effects on cancer survivors’ quality of life of physical training versus physical training combined with cognitive-behavioral therapy: results from a randomized trial

Long-term effects on cancer survivors’ quality of life of physical training versus physical training combined with cognitive-behavioral therapy: results from a randomized trial

The effect of group cohesion on rehabilitation outcome in cancer survivors

Cognitive behaviour therapy for fatigued cancer survivors: long-term follow-up

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