Randomized controlled trial of screening for hepatocellular carcinoma

Zhang, Boheng; Yang, Benlong; Tang, Zhao–You

doi:10.1007/s00432-004-0552-0

Cited by 1,186 publications

(1,017 citation statements)

References 12 publications

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“…These results are consistent with several previous studies exploring evolutionary temporal trends in HCC. The role of HCC surveillance in chronic liver disease has become well established over the years, with benefits reported in several studies 42, 43, 44. Similarly, a significant improvement in diagnostic modalities, such as dynamic computerized tomography, contrast‐enhanced magnetic resonance imaging, and ultrasound, has also played an important role in detecting HCC earlier 35.…”

Section: Discussionmentioning

confidence: 99%

Deciphering the epidemiology of hepatocellular carcinoma through the passage of time: A study of 1,401 patients across 3 decades

Goh

Chang

et al. 2017

Hepatology Communications

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Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers globally. With advances in therapy for chronic viral hepatitis, changing social circumstances, and increasing practice of HCC surveillance, the epidemiology of HCC is expected to change over time. We explored the temporal trends in HCC in Singapore, a multiethnic Asian country, over the last 3 decades. Patients with HCC were prospectively enrolled and stratified into two cohorts (C1, 1988‐2002; C2, 2003‐2016). Patient and tumor characteristics, management, and survival were compared between the two cohorts, and a survival census was performed on October 31, 2015. There were 1,401 patients, and the mean age at diagnosis of HCC for C1 and C2 was 60.1 and 63.5 years, respectively. Male patient preponderance decreased significantly, with the male to female ratio falling from 5.2:1 to 3.9:1 between C1 and C2. Hepatitis B, although still the predominant risk factor for HCC, showed a significant decline from C1 to C2 (76.5% to 68.2%), while the nonviral etiology increased significantly over the same period (14.4% versus 25.0%, respectively). Significantly more patients in C2 than C1 were diagnosed through surveillance (39.2% versus 11.3%, respectively) and had better physical performance (Eastern Cooperative Oncology Group 0, 62.1% versus 20.4%, respectively). While Child‐Pugh status was comparable, significantly more patients in C2 than C1 had early stage disease (Barcelona Clinic Liver Cancer 0‐A, 39.5% versus 7.4%, respectively), which translated into significantly higher median survival (18.6 months versus 3.8 months, respectively). Conclusion: Over the past 3 decades, hepatitis B‐related HCC has been decreasing while HCC due to nonviral etiology has been increasing significantly. Surveillance to diagnose early stage HCC is important in improving the outcome of HCC. (Hepatology Communications 2017;1:564–571)

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Section: Discussionmentioning

confidence: 99%

Deciphering the epidemiology of hepatocellular carcinoma through the passage of time: A study of 1,401 patients across 3 decades

Goh

Chang

et al. 2017

Hepatology Communications

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“…However, the effectiveness of surveillance programs has still to be demonstrated through prospective RCTs, comparing the survival of participants with or without surveillance, though they may be susceptible to lead-time bias. To date, there is only one study that has proved the benefit of surveillance [139]. Zhang et al [139] recruited 18,186 patients with chronic hepatitis due to HBV in China.…”

Section: Rationale For Surveillancementioning

confidence: 99%

“…To date, there is only one study that has proved the benefit of surveillance [139]. Zhang et al [139] recruited 18,186 patients with chronic hepatitis due to HBV in China. The study revealed that surveillance with biannual AFP measurement and US reduced the mortality from HCC by 37% in spite of the fact that the compliance of scheduled tests was only 58.2%.…”

Section: Rationale For Surveillancementioning

confidence: 99%

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

et al. 2010

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Introduction The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on the management of hepatocellular carcinoma (HCC) in December 2008 to develop consensus recommendations. Methods The working party consisted of expert hepatologist, hepatobiliary surgeon, radiologist, and oncologist from Asian-Pacific region, who were requested to make drafts prior to the consensus meeting held at Bali, Indonesia on 4 December 2008. The quality of existing evidence and strength of recommendations were ranked from 1 (highest) to 5 (lowest) and from A (strongest) to D (weakest), respectively, according to the Oxford system of evidence-based approach for developing the consensus statements. 123Hepatol Int (2010) 4: 439-474 DOI 10.1007/s12072-010-9165-7 Results Participants of the consensus meeting assessed the quality of cited studies and assigned grades to the recommendation statements. Finalized recommendations were presented at the fourth APASL single topic conference on viral-related HCC at Bali, Indonesia and approved by the participants of the conference.

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“…During the past 20 years, major efforts have been made to identify patients at risk of developing HCC, and screening programs for detecting HCC have been introduced. 9,10 Currently, approximately half of patients with HCC who receive care at referral centers and a considerably smaller proportion of patients in community practices are diagnosed at an early stage before cancer-related symptoms have developed.…”

Section: Rationale For Advocating Liver Transplantation For Hccmentioning

confidence: 99%

Toward optimizing the indications for orthotopic liver transplantation in hepatocellular carcinoma

Samuel

Colombo²,

El-Serag

et al. 2011

Liver Transpl

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Randomized controlled trial of screening for hepatocellular carcinoma

Abstract: Our finding indicated that biannual screening reduced HCC mortality by 37%.

Cited by 1,186 publications

References 12 publications

Deciphering the epidemiology of hepatocellular carcinoma through the passage of time: A study of 1,401 patients across 3 decades

Deciphering the epidemiology of hepatocellular carcinoma through the passage of time: A study of 1,401 patients across 3 decades

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

Toward optimizing the indications for orthotopic liver transplantation in hepatocellular carcinoma

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