Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment

Raghav, Sangeeta; Singh, Harjeet; Dalal, Pronob Kumar; Srivastava, J. S.; Asthana, Omkar P.

doi:10.4103/0019-5545.31555

Cited by 61 publications

(59 citation statements)

References 8 publications

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“…Diseases can be prevented by following a proper daily routine and seasonal living. The rich repository of unique efficacious plants mentioned in Āyurveda has elicited a significant hope in current drug discovery research, which is characterized by a target-rich and lead-poor scenario [55,56]. Increased interest is being witnessed at a global scale to evolve drug discovery strategies based on natural products and traditional medicine, and it is being increasingly realized that development of new drugs need not always be restricted to new molecular entities [57].…”

Section: Discussionmentioning

confidence: 99%

“…No abnormalities were observed in genotoxicity and mutagenicity [52]. The product was efficacious in the treatment of children suffering from attention deficit hyperactive disorder [53] and adults suffering from age-associated memory impairment [54,55,56] (Figure 13, Figure 14). …”

Section: Medhya-rasayana (Memory Enhancing and Rejuvenating) Plantsmentioning

confidence: 99%

“…BESEB CDRI-08 has shown its significant effectiveness in improving the cognitive symptoms associated with inattention, impulsiveness in children suffering from Attention Deficit Hyperactivity Disorder [53] and also showed significant improvement in several memory test scores on elderly subjects suffering from Age Associated Memory Impairment [54,55,56]. The extract has thus shown its putative potentials in the treatment of cognitive impairment.…”

Section: Medhya-rasayana (Memory Enhancing and Rejuvenating) Plantsmentioning

confidence: 99%

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Brain Enhancing Ingredients from Āyurvedic Medicine: Quintessential Example of Bacopa monniera, a Narrative Review

Singh¹

2013

Nutrients

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Āyurveda, the science (ved) of life (ayu), owing its origin to Veda, the oldest recorded wisdom of human civilization written in 3500 BCE, contains extensive knowledge of various diseases and their therapeutic approaches. It essentially relied on nature and the immune system of an individual, and therapeutic interventions were introduced only to augment the immune system. Āyurveda had eight specialties, including psycho-neuroscience (a combination of psychology, clinical psychology and psychiatry) and a unique promotive therapy encompassing nutrition, rejuvenation and geriatrics. The symptoms of various brain disorders, including memory disorder, were well defined. The goal of Āyurveda was to help an individual to achieve his cherished goal of leading a healthy life of 100 years. To achieve this, great emphasis was laid on nutrition, diet and a good conduct by the two great exponents of Āyurveda viz. Carak and Suśruta. By following these regimens, an individual could lead a less stressful life free from emotional disturbances. Both Carak and Suśruta had believed that these in combination with rasayana (rejuvenating) plants could enable an individual to lead a healthy life of 100 years.

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Section: Discussionmentioning

confidence: 99%

Section: Medhya-rasayana (Memory Enhancing and Rejuvenating) Plantsmentioning

confidence: 99%

Section: Medhya-rasayana (Memory Enhancing and Rejuvenating) Plantsmentioning

confidence: 99%

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Brain Enhancing Ingredients from Āyurvedic Medicine: Quintessential Example of Bacopa monniera, a Narrative Review

Singh¹

2013

Nutrients

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“…In addition, it has been demonstrated that consumption of B. monnieri at a dose of 300 mg per day can enhance logical memory, paired associated learning, and mental control in age-associated memory impairment (AAMI) subjects without serious adverse effects. However, “flu-like symptoms” and “digestive problems” were also observed [16]. A systematic review of studies also shows that consumption of B. monnieri at doses of 300–450 mg/day can enhance memory recall [17–22].…”

Section: Introductionmentioning

confidence: 99%

Effects of 12-WeekBacopa monnieriConsumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers

Peth-Nui

Wattanathorn

Muchimapura

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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At present, the scientific evidence concerning the effect of Bacopa monnieri on brain activity together with working memory is less available. Therefore, we aimed to determine the effect of B. monnieri on attention, cognitive processing, working memory, and cholinergic and monoaminergic functions in healthy elderly. A randomized double-blind placebo-controlled design was utilized. Sixty healthy elderly subjects (mean age 62.62 years; SD 6.46), consisting of 23 males and 37 females, received either a standardized extract of B. monnieri (300 and 600 mg) or placebo once daily for 12 weeks. The cholinergic and monoaminergic systems functions were determined using AChE and MAO activities. Working memory was assessed using percent accuracy and reaction time of various memory tests as indices, whereas attention and cognitive processing were assessed using latencies and amplitude of N100 and P300 components of event-related potential. All assessments were performed before treatment, every four weeks throughout study period, and at four weeks after the cessation of intervention. B. monnieri-treated group showed improved working memory together with a decrease in both N100 and P300 latencies. The suppression of plasma AChE activity was also observed. These results suggest that B. monnieri can improve attention, cognitive processing, and working memory partly via the suppression of AChE activity.

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“…The mechanism of action purported to be responsible for these cognitive enhancements is linked to the mitigation and protection of neuronal cholinergic systems following administration of B.monnieri [ 9 , 12 , 13 ]. Recent innovative research reported significant improvements in memory in healthy older adults [ 14 ], as well as in a population of older adults with age-associated memory impairment [ 15 ] following administration with B.monnieri. These findings show promise for ageing research, with cholinergic degeneration a major clinical feature of both age-related cognitive decline and Alzheimer’s dementia [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic Overview of Bacopa monnieri (L.) Wettst. Dominant Poly-Herbal Formulas in Children and Adolescents

2017

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Background: The Ayurvedic medicinal system employs a holistic approach to health, utilising the synergistic properties of organic resources. Research into the Ayurvedic herb Bacopa monnieri (L.) Wettst. (B.monnieri) has reported improvements in cognitive outcomes in child and adult populations. The aim of current review is to systematically assess and critically summarize clinical trials investigating B.monnieri-dominant poly-herbal formulas and their effects on the cognition, memory, learning, and behaviour in children and adolescents. Methods: Key word searches were performed using PubMed, Scopus, Cochrane Library, DHARA, and CINAHL for publications meeting inclusion criteria up to November 2017. There were no restrictions in study design. Effect sizes were calculated for all significant findings to allow for direct comparisons, and each study was evaluated on design quality. Cognitive and behavioural outcomes were grouped into validated constructs for cross-study comparison. Results: Nine trials met inclusion criteria. Five studies reported sufficient data for effect size analysis with most improvements reported in behavioural outcomes. True cognitive abilities and behavioural constructs were reviewed in six studies, with visual perception, impulsivity, and attention demonstrating the greatest improvements. The veracity of the evidence for the formulations reviewed is weakened by inconsistent statistical design and under-reporting of safety and tolerability data (44%). Conclusions: The current review extends research supporting B.monnieri as a cognitive enhancer and provides modest evidence for the use of B.monnieri in poly-herbal preparations for improving cognitive and behavioural outcomes in child and adolescent populations. Greater emphasis on statistical vigour and the reporting of tolerability data are essential for future trials to adequately document poly-herbal treatment efficacy.

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Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment

Cited by 61 publications

References 8 publications

Brain Enhancing Ingredients from Āyurvedic Medicine: Quintessential Example of Bacopa monniera, a Narrative Review

Brain Enhancing Ingredients from Āyurvedic Medicine: Quintessential Example of Bacopa monniera, a Narrative Review

Effects of 12-WeekBacopa monnieriConsumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers

Systematic Overview of Bacopa monnieri (L.) Wettst. Dominant Poly-Herbal Formulas in Children and Adolescents

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