Randomized controlled trials in neurosurgery

Takroni, Radwan; Sharma, Sunjay; Reddy, Kesava; Zagzoog, Nirmeen; Aljoghaiman, Majid; Alotaibi, Mazen; Farrokhyar, Forough

doi:10.25259/sni_1032_2021

Cited by 6 publications

(3 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another critical limitation observed here, relevant to future research, was the inability to "double blind" patients and surgeons a key method for reducing detection bias. This problem underlies any technical advancement in surgery, namely trials of non-pharmacological treatments with physical components (70)(71)(72)(73). As a result, surgeons who trusted in the efficacy of AR may have-unconsciously or deliberately-influenced the EOR.…”

Section: Discussionmentioning

confidence: 99%

“…VR technology has been of great utility due to its specific metric-based performance assessment which is outside the angio suite as well as its ability to conduct complex neuro interventions, such as mechanical thrombectomy, accompanied by the similar set of principles as in live patients (72). Surgeons can also benefit from gain access to a VR-based patient-specific model for better planning management or diagnosing strategies, along with planning complex hybrid or combined procedures requiring a combination of conventional and interventional surgical methods (73)(74)(75).…”

Section: Augmented and Virtual Reality In Neurosurgerymentioning

confidence: 99%

See 1 more Smart Citation

Advances in Artificial Intelligence, Robotics, Augmented and Virtual Reality in Neurosurgery

Mofatteh,

Bydon,

Ali Alvi

2024

Frontiers Research Topics

View full text Add to dashboard Cite

Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Augmented and Virtual Reality In Neurosurgerymentioning

confidence: 99%

Advances in Artificial Intelligence, Robotics, Augmented and Virtual Reality in Neurosurgery

Mofatteh,

Bydon,

Ali Alvi

2024

Frontiers Research Topics

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Intra-operative applications of augmented reality in glioma surgery: a systematic review

Ragnhildstveit,

Li,

Zimmerman

et al. 2023

Front. Surg.

View full text Add to dashboard Cite

BackgroundAugmented reality (AR) is increasingly being explored in neurosurgical practice. By visualizing patient-specific, three-dimensional (3D) models in real time, surgeons can improve their spatial understanding of complex anatomy and pathology, thereby optimizing intra-operative navigation, localization, and resection. Here, we aimed to capture applications of AR in glioma surgery, their current status and future potential.MethodsA systematic review of the literature was conducted. This adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. PubMed, Embase, and Scopus electronic databases were queried from inception to October 10, 2022. Leveraging the Population, Intervention, Comparison, Outcomes, and Study design (PICOS) framework, study eligibility was evaluated in the qualitative synthesis. Data regarding AR workflow, surgical application, and associated outcomes were then extracted. The quality of evidence was additionally examined, using hierarchical classes of evidence in neurosurgery.ResultsThe search returned 77 articles. Forty were subject to title and abstract screening, while 25 proceeded to full text screening. Of these, 22 articles met eligibility criteria and were included in the final review. During abstraction, studies were classified as “development” or “intervention” based on primary aims. Overall, AR was qualitatively advantageous, due to enhanced visualization of gliomas and critical structures, frequently aiding in maximal safe resection. Non-rigid applications were also useful in disclosing and compensating for intra-operative brain shift. Irrespective, there was high variance in registration methods and measurements, which considerably impacted projection accuracy. Most studies were of low-level evidence, yielding heterogeneous results.ConclusionsAR has increasing potential for glioma surgery, with capacity to positively influence the onco-functional balance. However, technical and design limitations are readily apparent. The field must consider the importance of consistency and replicability, as well as the level of evidence, to effectively converge on standard approaches that maximize patient benefit.

show abstract

Spinal Cord Stimulation vs Medical Management for Chronic Back and Leg Pain

Huygen,

Soulanis,

Rtveladze

et al. 2024

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceChronic back and lower extremity pain is one of the leading causes of disability worldwide. Spinal cord stimulation (SCS) aims to improve symptoms and quality of life.ObjectiveTo evaluate the efficacy of SCS therapies compared with conventional medical management (CMM).Data SourcesMEDLINE, Embase, and Cochrane Library were systematically searched from inception to September 2, 2022.Study SelectionSelected studies were randomized clinical trials comparing SCS therapies with sham (placebo) and/or CMM or standard treatments for adults with chronic back or leg pain who had not previously used SCS.Data Extraction and SynthesisEvidence synthesis estimated odds ratios (ORs) and mean differences (MDs) and their associated credible intervals (CrI) through bayesian network meta-analysis. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline for network meta-analyses was followed.Main Outcomes and MeasuresThe primary outcomes were pain-related end points, including pain intensity (measured by visual analog scale) and proportion of patients achieving at least 50% pain relief (responder rate) in the back or leg. Quality of life (measured by EQ-5D index score) and functional disability (measured by the Oswestry Disability Index score) were also considered.ResultsA total of 13 studies of 1561 patients were included in the network meta-analysis comparing conventional and novel SCS therapies with CMM across the 6 outcomes of interest at the 6-month follow-up. Both conventional and novel SCS therapies were associated with superior efficacy compared with CMM in responder rates in back (conventional SCS: OR, 3.00; 95% CrI, 1.49 to 6.72; novel SCS: OR, 8.76; 95% CrI, 3.84 to 22.31), pain intensity in back (conventional SCS: MD, −1.17; 95% CrI, −1.64 to −0.70; novel SCS: MD, −2.34; 95% CrI, −2.96 to −1.73), pain intensity in leg (conventional SCS: MD, −2.89; 95% CrI, −4.03 to −1.81; novel SCS: MD, −4.01; 95% CrI, −5.31 to −2.75), and EQ-5D index score (conventional SCS: MD, 0.15; 95% CrI, 0.09 to 0.21; novel SCS: MD, 0.17; 95% CrI, 0.13 to 0.21). For functional disability, conventional SCS was superior to CMM (MD, −7.10; 95% CrI, −10.91 to −3.36). No statistically significant differences were observed for other comparisons.Conclusions and RelevanceThis systematic review and network meta-analysis found that SCS therapies for treatment of chronic pain in back and/or lower extremities were associated with greater improvements in pain compared with CMM. These findings highlight the potential of SCS therapies as an effective and valuable option in chronic pain management.

show abstract

Randomized controlled trials in neurosurgery

Cited by 6 publications

References 63 publications

Advances in Artificial Intelligence, Robotics, Augmented and Virtual Reality in Neurosurgery

Advances in Artificial Intelligence, Robotics, Augmented and Virtual Reality in Neurosurgery

Intra-operative applications of augmented reality in glioma surgery: a systematic review

Spinal Cord Stimulation vs Medical Management for Chronic Back and Leg Pain

Contact Info

Product

Resources

About