Randomized phase II study of combined infusional leucovorin sodium (LVNa) and 5-FU versus the sequential administration of leucovorin calcium (LVCa) followed by 5-FU with irinotecan or oxaliplatin in patients (pts) with metastatic colorectal cancer (mCRC).

Prospective Observational Study Comparing Calcium and Sodium Levofolinate in Combination with 5-Fluorouracil in the FOLFIRI Regimen

“…Given the small sample size, the heterogeneity of enrolled patients in relation to tumor site and treatment line (Table 1), and the absence of randomization, it was not possible to draw any definitive conclusions about the effectiveness of the Na-Lev +5-FU combination. Several phase II clinical trials have suggested the noninferiority of Na-Lev with respect to Ca-Lev in terms of efficacy and a similar toxicity profile [7][8][9][10][11][12][13][14][15][16]. The toxicity profile was similar in the present trial, with a trend toward higher G1-2 mucositis in the Na-Lev arm and higher G1-2 nausea and vomiting in the Ca-Lev arm.…”

Naringenin-Mediated ATF3 Expression Contributes to Apoptosis in Human Colon Cancer

“…Surgery, radiation or chemotherapy has been regarded as the most effective adjuvant therapy in many cases. However, oxaliplatin, leucovorin and irinotecan as commonly used chemotherapeutic agents are associated with severe adverse effects ( Bleiberg et al ., 2012 ). Thus, there is a need for more potent and less toxic drugs.…”

Curcumin-polymeric nanoparticles against colon-26 tumor-bearing mice: cytotoxicity, pharmacokinetic and anticancer efficacy studies

“…Major treatments for CRC include surgery and radiation or chemotherapy, which are applied as adjuvant therapy in many cases. Anticancer agents such as oxaliplatin, leucovorin and irinotecan are known to be used, but they are often associated with severe side effects 3 . Therefore, to avoid these side effects, there is an urgent need to discover more potent anti-cancer agents with no side effects on normal organs/ tissues.…”