Randomized Trial of Cold Plasma and Vitamin C Synergy: Effects on Skin Hydration and Wrinkle Reduction

Abstract

As the skin ages, it naturally becomes drier and loses elasticity, resulting in wrinkles. Over time, the production of collagen and elastin in the skin decreases. Several methods exist for reducing skin wrinkles, including cold plasma technology. Plasma is an advanced treatment employed for skin rejuvenation and aesthetic enhancement. This technique can enhance skin appearance by boosting collagen and elastin production, thereby diminishing wrinkles. This study utilizes a FEDBD device for hand skin rejuvenation. The plasma treatment was administered over 8 sessions spanning 8 weeks. Skin analyses and laboratory tests such as elasticity, oxygenation, perfusion, tissue water index, and hemoglobin were performed before the plasma treatment, immediately after the treatment, at the fourth and eighth weeks of treatment, and six weeks post-final session. The findings of this study suggest that plasma can assist in cleansing the skin surface through the production of CO and OH. Additionally, an increase in the maintenance of skin hydration and enhanced oxygenation and perfusion was reported. The data reveal that, while vitamin C alone does not significantly improve skin elasticity, combining it with plasma treatments, particularly at 7.4 W, leads to a notable enhancement in skin elasticity over time that proves the synergy effect of cold plasma. The combination therapy is the most effective in improving skin elasticity compared to other treatments.