Randomized Trial of Erythromycin and Azithromycin for Treatment of Chlamydial Infection in Pregnancy

Single-dose azithromycin versus erythromycin or amoxicillin for Chlamydia trachomatis infection during pregnancy: a meta-analysis of randomised controlled trials

“…From the remaining nine RCTs, eight [22][23][24][25][26][27][28][29] were finally included in the meta-analysis. Seven RCTs [22][23][24][25][26][27]29] were published articles, whilst one RCT [28] was an abstract from a clinical conference. Table 1 lists the characteristics of the eight RCTs [22][23][24][25][26][27][28][29] included in the meta-analysis.…”

“…Seven RCTs [22][23][24][25][26][27]29] were published articles, whilst one RCT [28] was an abstract from a clinical conference. Table 1 lists the characteristics of the eight RCTs [22][23][24][25][26][27][28][29] included in the meta-analysis. Overall, 587 patients with C. trachomatis infection were enrolled, whilst 509 patients comprised the ITT population and 470 patients comprised the CE population.…”

“…The mean quality score of the included RCTs was 3.25 (range 2-4). The quality score of five RCTs [22,23,25,27,29] was 4, whilst the quality score of three RCTs [24,26,28] was 2. All RCTs described the studies as randomised, provided details regarding withdrawals and did not use the double-blind method.…”

“…All RCTs described the studies as randomised, provided details regarding withdrawals and did not use the double-blind method. Five RCTs [22,23,25,27,29] performed the randomisation using a generation of random numbers of allocation and insured allocation concealment.…”

“…Five RCTs [22][23][24][25]27] presented the mean duration of gestational weeks at enrolment, whilst one RCT [26] presented the median duration and two RCTs [28,29] did not provide relevant data. The demographic characteristics did not vary between the different studies.…”