Randomized trial of vigabatrin in patients with infantile spasms

Elterman, Roy D.; Shields, W. Donald; Mansfield, K. A.; Nakagawa, Jo Anne

doi:10.1212/wnl.57.8.1416

Cited by 206 publications

(159 citation statements)

References 26 publications

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“…In the study of 179 infants by Elterman et al [40] (Class III), which also included video EEG, the response rates with vigabatrin were very similar to the Finnish study: 23 % at day 14 but 60 % at 3 months. Thus, the response to vigabatrin seems to come later and in fewer infants than ACTH.…”

Section: Is Acth More Effective Than Vigabatrin For Shortterm Treatmesupporting

confidence: 54%

“…Thus, the response to vigabatrin seems to come later and in fewer infants than ACTH. Large doses of vigabatrin (100-140 mg/kg/day) were more effective than the small doses (18-36 mg/kg/ day) in the study by Elterman et al [40,41].…”

Section: Is Acth More Effective Than Vigabatrin For Shortterm Treatmementioning

confidence: 80%

“…The first small prospective study in children with infantile spasms and an underlying diagnosis of TS found vigabatrin to be more efficient than hydrocortisone at stopping the spasms [45]. In the study by Elterman et al [40], which included subjects with TS, there were significantly more responders among children who had TS (13 of 15) compared with other aetiologies (19/117; p \ 0.001). Vigabatrin has been considered the drug of first choice in TS [8].…”

Section: Tuberous Sclerosis (Ts)mentioning

confidence: 97%

“…After pooling the data of eight separate prospective and retrospective studies, vigabatrin had a good response on spasms in 44 % of 478 patients [11,22,31,39,40,[45][46][47]. In the pooled data of nine separate prospective and retrospective studies, ACTH had a good response on spasms in 59 % of 476 patients [22, 24, 26-29, 34, 48, 49].…”

Section: Is Acth More Effective Than Vigabatrin For Shortterm Treatmementioning

confidence: 99%

“…The common side effects of both drugs are irritability, sleep disturbances and drowsiness [27,39,40,48,66]. Both drugs also have severe side effects.…”

Section: Side Effects Of Corticosteroids and Vigabatrinmentioning

confidence: 99%

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Recent Advances in the Pharmacotherapy of Infantile Spasms

Riikonen

2014

CNS Drugs

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Adrenocorticotrophic hormone (ACTH), oral corticosteroids and vigabatrin are now first-line treatments for infantile spasms in the US and Europe. There is now increased knowledge regarding the role of ACTH, corticosteroids and vigabatrin (e.g. efficacy, doses, side effects, treatment in specific aetiological subtypes of infantile spasms), and other antiepileptic drugs (i.e. topiramate, valproate, zonisamide, sulthiame, levetiracetam, lamotrigine, pyridoxine, ganaxolone), as well as adjunctive flunarizine and novel drugs not yet in clinical use for infantile spasms (i.e. pulse rapamycin and melanocortin receptor agonists). The existence of a latent period, weeks to months following a precipitating brain insult, raises the possibility of preventive interventions. Recent experimental data emerging from animal models of infantile spasms have provided optimism that new and innovative treatments can be developed, and knowledge that drug treatment can affect long-term cognitive outcome is increasing. The aim of this article is to review recent developments in the pharmacotherapy of infantile spasms and to highlight the practical implications of the latest research.

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Section: Is Acth More Effective Than Vigabatrin For Shortterm Treatmesupporting

confidence: 54%

Section: Is Acth More Effective Than Vigabatrin For Shortterm Treatmementioning

confidence: 80%

Section: Tuberous Sclerosis (Ts)mentioning

confidence: 97%

Section: Is Acth More Effective Than Vigabatrin For Shortterm Treatmementioning

confidence: 99%

“…The common side effects of both drugs are irritability, sleep disturbances and drowsiness [27,39,40,48,66]. Both drugs also have severe side effects.…”

Section: Side Effects Of Corticosteroids and Vigabatrinmentioning

confidence: 99%

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