Range of Normal Liver Stiffness and Factors Associated With Increased Stiffness Measurements in Apparently Healthy Individuals

Bazerbachi, Fateh; Haffar, Samir; Wang, Zhen; Cabezas, Joaquín; Arias-Loste, María Teresa; Crespo, Javier; Murad, Sarwa Darwish; Ikram, M. Arfan; Olynyk, John K.; Gan, Eng K.; Petta, Salvatore; Berzuini, Alessandra; Prati, Daniele; Lédinghen, Victor de; Wong, Vincent Wai‐Sun; Poggio, P. Del; Chávez-Tapia, Norberto C.; Chen, Yong Peng; Cheng, Pin Nan; Yuen, Man Fung; Das, Kausik; Chowdhury, Abhijit; Caballería, Llorenç; Fabrellas, Núria; Ginès, Pere; Kumar, Manoj; Sarin, Shiv Kumar; Conti, Fabio; Andreone, Pietro; Şirli, Roxana; Cortez‐Pinto, Helena; Carvalhana, Sofia; Sugihara, Takaaki; Kim, Seung Up; Parikh, Pathik; Chayama, Kazuaki; Corpechot, Christophe; Kim, Kang Mo; Papatheodoridis, George V.; Alsebaey, Ayman; Kamath, Patrick S.; Murad, Mohammad Hassan; Watt, Kymberly D.

doi:10.1016/j.cgh.2018.08.069

Cited by 69 publications

(65 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in line with the observation that TE may overestimate the extent of liver fibrosis in overweight individuals. 41 On the other hand, previous studies support the TE findings in that they suggested a promoting effect of obesity on liver disease development in Pi*ZZ carriers. 42,43 Another limitation of LSM, which has been carefully addressed in our study, is its potential affection by hepatic congestion (eg, caused by right-sided heart failure).…”

Section: Discussionmentioning

confidence: 68%

Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation

et al. 2019

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 68%

Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation

et al. 2019

View full text Add to dashboard Cite

“…In presumably healthy individuals, several studies have demonstrated a significant increase in LSM in those with hepatic steatosis on ultrasound compared to those without steatosis. 3,[33][34][35] In our study, we have extended this observation to the paediatric population.…”

Section: Sensitivity Analysis Including All Individuals In Ipd Cohortmentioning

confidence: 72%

“…14 We kept items focused on the representativeness of the cases and ascertainment of outcome and removed items that related to the selection of the controls and comparability. This tool has been applied in many previous publications, 3,[15][16][17][18] with good consistency among reviewers. The assessment of methodologic quality for the 10 included cohorts and the overall risk of bias for these cohorts are found in Supplemental Information.…”

Section: Assessment Of Methodologic Qualitymentioning

confidence: 99%

“…2 With the widening use of this non-invasive technique, there has been increased interest in determining the normal LSM range in healthy individuals. While the normal LSM range has been identified in adults, 3 no systematic review has evaluated the normal values for LSM in children and there are only data available from a small number of studies in healthy children. [4][5][6][7][8][9][10] In this systematic review and individual participant data (IPD) meta-analysis, we aimed to define the normal range of TE-derived LSM, as well as identify factors influencing this range by synthesizing studies reporting the measurements in ostensibly healthy children.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Normal liver stiffness and influencing factors in healthy children: An individual participant data meta‐analysis

Khan

Wang

et al. 2020

Liver International

Self Cite

View full text Add to dashboard Cite

show abstract

“…A recent meta-analysis collected data on TE values in healthy individuals identifying 26 studies and a total of 16,082 participants [50]. The mean liver stiffness in nonobese individuals was 4.68 kPa, with increased stiffness measurements in individuals with diabetes, increasing waist circumference, obesity, elevated serum transaminases or hypertension.…”

Section: Other Studiesmentioning

confidence: 99%

The Enhanced Liver Fibrosis test is associated with liver-related outcomes in postmenopausal women with risk factors for liver disease

et al. 2020

View full text Add to dashboard Cite

Background: Chronic liver disease (CLD) is usually asymptomatic but earlier detection is critical to permit lifesaving interventions for those at risk due to high alcohol consumption and increased body mass index (BMI). The aim of this study was to estimate the association between the Enhanced Liver Fibrosis (ELF) test and liver-related events (LRE) and its performance in predicting LRE in postmenopausal women with risk factors in a nested case-control study within the United Kingdom Trial of Ovarian Cancer Screening (UKCTOCS).Methods: In a cohort of 95,126 we performed a case-control study measuring ELF in blinded samples from 173 participants with self-reported high alcohol use and / or BMI ≥25 kg/m 2 comprising all 58 cases who developed LRE and 115 controls matched for age, alcohol and BMI who did not develop LRE during median follow-up of 8.5 years.Results: Using Cox regression at an ELF threshold of 10.51 hazard ratios (HR) for LRE were 4.88 (95% confidence interval (CI) 2.37-10.03) (unadjusted model) and 4.62 (95% CI 2.12-10.08) (adjusted for deprivation and self-reported hypertension, heart disease, hypercholesterolaemia and diabetes). At a threshold of 9.8 HR for LRE were 2.21 (95% CI 1.22-3.97) (unadjusted model) and 2.18 (95% CI 1.19-4.01) (adjusted). ELF was evaluated as a time dependent variable by generating time-dependent Cox models; HRs at an ELF threshold of 10.51 were 1.94 (95% CI 1.10-3.39) (unadjusted) and 2.05 (95% CI 1.16-3.64) (adjusted) and at a threshold of 9.8 HRs were 1.85 (95% CI 1.09-3.15) (unadjusted) and 1.80 (95% CI 1.04-3.13) (adjusted). Area under the receiver operating characteristic curve for recruitment ELF predicting LRE was 0.58 (95% CI 0.49-0.68), and for second subsequent ELF 0.61 (95% CI 0.52-0.71). Conclusion:This study demonstrates the association between ELF and CLD in postmenopausal women with risk factors for liver disease, creating the opportunity to intervene to reduce liver-related mortality and morbidity. Although larger studies are required, these results demonstrate the potential of ELF as a prognostic tool in health checks in primary care.(Continued on next page)

show abstract

Range of Normal Liver Stiffness and Factors Associated With Increased Stiffness Measurements in Apparently Healthy Individuals

Cited by 69 publications

References 40 publications

Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation

Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation

Normal liver stiffness and influencing factors in healthy children: An individual participant data meta‐analysis

The Enhanced Liver Fibrosis test is associated with liver-related outcomes in postmenopausal women with risk factors for liver disease

Contact Info

Product

Resources

About