Ranitidine anaphylaxis: A rare occurrence

Vyas, Varsha; Mohite, Shubha N; Khatavkar, Sonal; Jagtap, Sheetal R

doi:10.4103/0019-5049.84826

Cited by 3 publications

(8 citation statements)

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“…Out of 100 fully evaluated, 52 references were included in the analysis as per selection criteria. [ 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 ] The flow diagram for the article selection is presented as Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…[ 13 ] History of anaphylaxis with same drugs (ranitidine and tinidazole) was positive in two cases. [ 55 64 ] In the case of tinidazole induced anaphylaxis, norfloxacin + tinidazole fixed dose combination caused oral mucosal lesions on first exposure; anaphylaxis and erythema multiforme on second exposure. On third exposure to tinidazole alone, patient developed anaphylaxis and Stevens Johnson syndrome.…”

Section: Resultsmentioning

confidence: 99%

“…[ 36 42 50 52 56 58 59 63 ] The drugs linked with anaphylaxis in pregnancy are iron sucrose (2), ranitidine (2), oxytocin (1), dinoprostone (1), cefotaxime (1) and diclofenac (1). Other co-morbid conditions were cardiovascular diseases (9.26%),[ 18 33 35 37 64 ] diabetes mellitus (3.70%),[ 37 64 ] chronic obstructive pulmonary disease (1.85%),[ 64 ] epilepsy (1.85%)[ 34 ] and cerebral malaria (1.85%). [ 53 ]…”

Section: Resultsmentioning

confidence: 99%

“…[ 55 ] The “definitely preventable,” “probably preventable” and “not preventable” cases were 12.96%, 1.85%, and 85.86%, respectively. Reasons for the preventability were past allergic reaction to the same drug (3),[ 26 55 64 ] immediate type of cutaneous reactions while ongoing treatment (2),[ 46 49 ] anaphylactic reaction with ongoing treatment (2)[ 37 39 ] and test dose not administered (1). [ 36 ]…”

Section: Resultsmentioning

confidence: 99%

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Drug-induced anaphylactic reactions in Indian population: A systematic review

Patel¹,

Patel²,

Barvaliya³

et al. 2014

Indian Journal of Critical Care Medicine

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Background:Epidemiological data on drug-induced anaphylactic reactions are limited in India and are largely depending on studies from developed countries.Aim:The aim was to analyze the published studies of drug-induced anaphylaxis reported from India in relation with causative drugs and other clinical characteristics.Materials and Methods:The electronic databases were searched for Indian publications from 1998 to 2013 describing anaphylactic reactions. The information was collected for demographics, set up in which anaphylaxis occurred, causative drugs, incubation period, clinical features, associated allergic conditions, past reactions, co-morbid conditions, skin testing, IgE assays, therapeutic intervention and mortality. Reactions were analyzed for severity, causality, and preventability. Data were extracted and summarized by absolute numbers, mean (95% confidence interval [CI]), percentages and odds ratio (OR) (95% CI).Results:From 3839 retrieved references, 52 references describing 54 reactions were included. The mean age was 35.31 (95% CI: 30.52–40.10) years. Total female patients were 61.11%. Majority reactions were developed in perioperative conditions (53.70%), ward (20.37%) and home (11.11%). The major incriminated groups were antimicrobials (18.52%), nonsteroidal antiinflammatory drugs-(NSAIDs) (12.96%) and neuromuscular blockers (12.96%). Common causative drugs were diclofenac (11.11%), atracurium (7.41%) and β-lactams (5.96%). Cardiovascular (98.15%) and respiratory (81.48%) symptoms dominated the presentation. Skin tests and IgE assays were performed in 37.03% and 18.52% cases, respectively. The fatal cases were associated with complications (OR =5.04; 95% CI: 1.41–17.92), cerebral hypoxic damage (OR =6.80; 95% CI: 2.14–21.58) and preventable reactions (OR =14.33; 95% CI: 2.33–87.97).Conclusion:Antimicrobials, NSAIDs, and neuromuscular blockers are common causative groups. The most fatal cases can be prevented by avoiding allergen drugs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Drug-induced anaphylactic reactions in Indian population: A systematic review

Patel¹,

Patel²,

Barvaliya³

et al. 2014

Indian Journal of Critical Care Medicine

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show abstract

“…So far, at least 10 cases of anaphylaxis have been reported with ranitidine, both oral[ 1 ] and intravenous preparation (bolus[ 2 3 4 5 6 ] as well as slow infusion[ 7 8 ]). Most of the reactions have occurred within minutes; in one case though, it was delayed up to 90 min.…”

Section: Introductionmentioning

confidence: 99%

Unusual and interesting adverse cutaneous drug reactions

2018

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Anaphylaxis following intravenous ranitidine: A rare adverse reaction of a common drug

et al. 2014

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Ranitidine hydrochloride is a widely used drug that is generally well-tolerated. Anaphylaxis is rarely observed with ranitidine. We report a case who developed severe anaphylaxis following single dose of intravenous ranitidine. The article highlights the importance of recognition of this serious adverse event and re-emphasizes the need for cautious use of drugs, especially in those with known history of allergy.

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Ranitidine anaphylaxis: A rare occurrence

Cited by 3 publications

References 4 publications

Drug-induced anaphylactic reactions in Indian population: A systematic review

Drug-induced anaphylactic reactions in Indian population: A systematic review

Unusual and interesting adverse cutaneous drug reactions

Anaphylaxis following intravenous ranitidine: A rare adverse reaction of a common drug

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