Rapamycin alleviates memory deficit against pentylenetetrazole-induced neural toxicity in Wistar male rats

Aghaie, Fatemeh; Shemshaki, Afsaneh; Rajabi, Mojgan; Khatami, Parisa; Hosseini, Abdolkarim

doi:10.1007/s11033-021-06504-9

Cited by 6 publications

(5 citation statements)

References 36 publications

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“…The PA test also showed that PTZ reduced RL and TLC, resulting in memory impairment in animals receiving PTZ. The results of this study are in line with reports that have been documented on memory impairment due to PTZ-induced seizures (Nagib et al, 2018;Aghaie et al, 2021;Hosseini, Allahyari, Azizi, 2021). With its effect on RL and TLC and its significant increase compared to the PTZ group, AMT reverses the effect of PTZ-induced memory impairment in rats, indicating its protective role against seizures and seizure-induced memory impairment.…”

Section: Discussionsupporting

confidence: 92%

Effect of amitriptyline on learning and memory consolidation in the male Wistar rats with an experimental model of pentylenetetrazole-induced seizure

Niazi

Mirazi

Hosseini

2023

Braz. J. Pharm. Sci.

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Amitriptyline (AMT) was developed for the treatment of chronic and neuropathic pain. There is also evidence it may be useful in the treatment of neurodegenerative disorders. In this regard, the effect of on the experimental model of seizures and memory impairment caused by seizures in rats is investigated in the present study. Seizures in Wistar rats (200-250 g) were induced by pentylenetetrazole (PTZ, 60 mg/kg, intraperitoneally (i.p.)). The anticonvulsant effect of AMT (10 and 20 mg/kg, i.p.) was evaluated in the seizure model. The effect on memory was assessed using passive avoidance (PA) learning and memory test. After behavioral tests, the animals underwent deep anesthesia and were put down painlessly. Animal serum was isolated for oxidant/antioxidant assays (malondialdehyde (MDA), and glutathione peroxidase (GPx)). Intraperitoneal injection of AMT decreased the mean number of myoclonic jerks and generalized tonic-clonic seizure (GTCS) duration and increased the mean latency of myoclonic jerk and GTCS compared to the PTZ group. Moreover, in the PA test, AMT caused a significant increase in retention latency (RL) and total time spent in the light compartment (TLC) compared to the PTZ group. Biochemical tests showed that AMT was able to significantly increase GPx serum levels and significantly reduce MDA serum levels compared to the PTZ group. Overall, this study suggests the potential neuroprotective effects of the AMT drug in a model of memory impairment caused by seizures via the mechanism of inhibition of the oxidative stress pathway.

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Section: Discussionsupporting

confidence: 92%

Effect of amitriptyline on learning and memory consolidation in the male Wistar rats with an experimental model of pentylenetetrazole-induced seizure

Niazi

Mirazi

Hosseini

2023

Braz. J. Pharm. Sci.

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“…The PA test also showed that PTZ reduced RL and TLC resulting in memory impairment in animals receiving PTZ. The results of this study are in line with reports that have been documented on memory impairment due to PTZ-induced seizures (Aghaie et al 2021;Hosseini et al 2021). With its effect on RL and TLC and its significant increase compared to the PTZ group, TVE reverses the effect of PTZ-induced memory impairment in rats, indicating its protective role against seizures and seizure-induced memory impairment.…”

Section: Discussionsupporting

confidence: 92%

“…The motor behavior of the animals in each group was recorded and stored by a computer-connected camera for half an hour after the PTZ injection and was examined by researcher in a double-blind manner. Based on The Racine scale in animals the six-stage stereotypical behavioral manifestations that were displayed after PTZ injections and the latency and number of myoclonic jerks and generalized tonic-clonic seizure (GTCS) latency and duration were evaluated (Table 1) (Hosseini et al 2021).…”

Section: Behavioral Evaluation Based On Racine Average Scorementioning

confidence: 99%

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Effects of Thymus vulgaris on passive avoidance learning and oxidative stress in pentylenetetrazole-induced model of memory impairment in the male Wistar rats

Hosseini

Azizi

Allahyari

2021

Journal of Cellular Neuroscience and Oxidative Stress

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Journal of Cellular Neuroscience and Oxidative Stress is an online journal that publishes original research articles, reviews and short reviews on the molecular basis of biophysical, physiological and pharmacological processes that regulate cellular function, and the control or alteration of these processes by the action of receptors, neurotransmitters, second messengers, cation, anions, drugs or disease.Areas of particular interest are four topics. They are;A-Ion Channels (Na + -K + Channels, Clchannels, Ca 2+ channels, ADP-Ribose and metabolism of NAD + , Patch-Clamp applications) B-Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) C-Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD + on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson's and Alzheimer's diseases) D-Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)

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“…The PA test also showed that PTZ caused memory impairment resulting in reduced RL and TLC. The results of this study are in line with reports on memory impairment due to PTZ-induced seizures (Aghaie et al 2021;Hosseini et al 2021;Nagib et al 2018). By inducing significant increase in RL and TLC compared to the PTZ group, ASE reversed the effect of PTZ-induced memory impairment, indicating its protective role against seizures and seizure-induced memory impairment.…”

Section: Discussionsupporting

confidence: 91%

Investigation of efficacy of asenapine on passive avoidance learning and memory and oxidative stress in animal model of seizure-induced with pentylenetetrazole

Farhadi,

Mirazi,

Hosseini

2022

Acta Biol Szeged

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Asenapine (ASE) has been used for treatment of bipolar disorder. There is also evidence that it may be useful in the treatment of neurodegenerative disorders. In this regard, the efficacy of ASE in an experimental model of seizure and memory impairment caused by seizures in rats has been investigated in the present study. Seizures in male Wistar rats (200-250 g) were induced by pentylenetetrazole (PTZ, 60 mg/kg, intraperitoneally (i.p.)), and the anticonvulsant effect of ASE (0.5 and 1 mg/kg, i.p.) was evaluated. The effect on memory was assessed using passive avoidance (PA) test in a shuttle box apparatus. After behavioral tests, the animals underwent deep anesthesia and were euthanized painlessly. Serum was isolated for oxidative stress assays (nitric oxide (NO), and glutathione (GSH)). Intraperitoneal injection of ASE decreased the mean number of myoclonic jerks and duration of generalized tonic clonic seizures (GTCS) and increased the mean latency of myoclonic jerk and GTCS compared to the PTZ group. Moreover, in the PA test, ASE caused a significant increase in retention latency (RL) and total time spent in the light compartment (TLC) compared to the PTZ group. Biochemical tests showed that ASE was able to significantly increase GSH serum levels and significantly reduce NO serum levels compared to the PTZ group. Overall, this study suggests the potential neuroprotective effects of ASE in a model of memory impairment caused by seizures via the mechanism of inhibition of the oxidative stress pathway.

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Rapamycin alleviates memory deficit against pentylenetetrazole-induced neural toxicity in Wistar male rats

Cited by 6 publications

References 36 publications

Effect of amitriptyline on learning and memory consolidation in the male Wistar rats with an experimental model of pentylenetetrazole-induced seizure

Effect of amitriptyline on learning and memory consolidation in the male Wistar rats with an experimental model of pentylenetetrazole-induced seizure

Effects of Thymus vulgaris on passive avoidance learning and oxidative stress in pentylenetetrazole-induced model of memory impairment in the male Wistar rats

Investigation of efficacy of asenapine on passive avoidance learning and memory and oxidative stress in animal model of seizure-induced with pentylenetetrazole

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