2017
DOI: 10.3892/etm.2017.4557
|View full text |Cite
|
Sign up to set email alerts
|

Rapamycin enhances the antiproliferative effect of transforming growth factor-β on MCF-7 human breast cancer cells

Abstract: Abstract. Transforming growth factor-β (TGF-β), a well-known cytokine with pleiotropic biological functions, has an important role in the regulation of cellular proliferation. Rapamycin has specific antagonistic activity on the function of the mammalian target of the rapamycin signaling pathway. The cooperation of TGF-β and rapamycin on the proliferation of Michigan Cancer Foundation (MCF)-7 human breast cancer cells is unclear. The present study demonstrated that TGF-β had a growth-arresting effect on MCF-7 c… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 6 publications
(1 citation statement)
references
References 31 publications
0
1
0
Order By: Relevance
“…TGF-β signaling exerts ambivalent properties in cancer with tumor suppressive effects at early stages and pro-metastatic action at a later stage [ 25 ]. TGF-β signaling has the ability to induce cell cycle arrest and/or apoptosis as well as to promote EMT and cell invasion in cancer cells, including breast cancer cells [ 26 , 27 ]. Active TGF-β elicits its biological effects by binding to serine/threonine kinase TGF-β receptors (TGFβ-R) 1 and 2 directly or with the help of the accessory TGFβ-R3.…”
Section: Discussionmentioning
confidence: 99%
“…TGF-β signaling exerts ambivalent properties in cancer with tumor suppressive effects at early stages and pro-metastatic action at a later stage [ 25 ]. TGF-β signaling has the ability to induce cell cycle arrest and/or apoptosis as well as to promote EMT and cell invasion in cancer cells, including breast cancer cells [ 26 , 27 ]. Active TGF-β elicits its biological effects by binding to serine/threonine kinase TGF-β receptors (TGFβ-R) 1 and 2 directly or with the help of the accessory TGFβ-R3.…”
Section: Discussionmentioning
confidence: 99%