Rapid analysis and residue evaluation of six fungicides in grape wine-making and drying

Hou, Xiai; Xu, Zhiyi; Zhao, Yufei; Liu, Dan

doi:10.1016/j.jfca.2020.103465

Cited by 30 publications

(18 citation statements)

References 23 publications

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“…36 And many studies have implied that the elimination rate of pesticides by washing might correlate with the octanol / water partition coefficient (logK ow ) and the solubility of pesticides. 37,38 As summarized in the supporting information, Table S3, the reduction rates of many pesticides (logK ow : 1.71-6.37) were in a range of 5.71-79% by washing with tap water in grapes and apples in publications. In this study, the removal efficiency of imazalil by washing was relatively low, which might have resulted from a relatively high logK ow (4.10) of imazalil.…”

Section: Fate and Enantioselectivity Of Imazalil And Imazalil-m In The Field Grapes And Applesmentioning

confidence: 99%

Monitoring the behavior of imazalil and its metabolite in grapes, apples, and the processing of fruit wine at enantiomeric level

Pan

et al. 2021

J Sci Food Agric

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BACKGROUND: Imazalil is widely used in agriculture, which may pose a threat to food safety. This study aimed to investigate the fate of imazalil and its main metabolite, R14821 (imazalil-M), in field grapes and apples, and in the processing of fruit wine at the enantiomeric level. RESULTS: Analysis method was established to determine imazalil and imazalil-M enantiomers in grape, apple, fruit wine and pomace. The method showed acceptable recoveries of 71.6-99.9% and precision with relative standard deviation of 0.3-11.7%. Processing factors (PFs) were 0.15-0.40 (for imazalil enantiomers) and <0.13-0.83 (for imazalil-M enantiomers) during the wine-making process. The PFs after individual steps including washing, peeling, fermentation, and clarification were all less than 1. No enantioselective dissipation of imazalil was found in grapes under field conditions with half-lives of 23.82-24.49 days. R-(−)-imazalil degraded slightly faster than S-(+)-imazalil in apples under field conditions with half-lives of 9.82-10.09 days. S-(+)-imazalil-M preferentially degraded in field grapes and apple. No significant enantioselectivity of imazalil and imazalil-M was observed during the wine-making process. The enantiomeric fraction (EF) values of imazalil were 0.484-0.511 and 0.509-0.522 in grape wine and cider, respectively. The EFs were 0.484-0.501(in grape wine) and 0.484-0.504 (in cider) for imazalil-M. CONCLUSION:The results showed that the wine-making process could reduce imazalil and imazalil-M residues in grapes and apples. The finding of non-enantioselectivity of imazalil during the processing of fruit wine was useful for accurate risk assessment for imazalil in raw and processing fruits.

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Section: Fate and Enantioselectivity Of Imazalil And Imazalil-m In The Field Grapes And Applesmentioning

confidence: 99%

Monitoring the behavior of imazalil and its metabolite in grapes, apples, and the processing of fruit wine at enantiomeric level

Pan

et al. 2021

J Sci Food Agric

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“…Hence, it may leach out into the ground water and flow into waterways by agricultural runoffs (Meite et al, 2018). In addition, residue of metalaxyl has been detected in honey, grape wine, and chrysanthemum flower used for tea infusion (El‐Nahhal, 2020; Hou et al, 2020; Jiang et al, 2020). It is likely that metalaxyl may enter the human body.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells

Saquib

Siddiqui

Ansari

et al. 2021

J of Applied Toxicology

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Pesticides have adverse effects on the cellular functionality, which may trigger myriad of health consequences. However, pesticides‐mediated toxicity in the endothelial cells (ECs) is still elusive. Hence, in this study, we have used human umbilical vein endothelial cells (HUVECs) as a model to quantify the cytotoxicity and genotoxicity of four pesticides (methomyl, carbaryl, metalaxyl, and pendimethalin). In the MTT assay, HUVECs exposed to methomyl, carbaryl, metalaxyl, and pendimethalin demonstrated significant proliferation inhibition only at higher concentrations (500 and 1000 μM). Likewise, neutral red uptake (NRU) assay also showed proliferation inhibition of HUVECs at 500 and 1000 μM by the four pesticides, confirming lysosomal fragility. HUVECs exposed to the four pesticides significantly increased the level of intracellular reactive oxygen species (ROS). Comet assay and flow cytometric data exhibited DNA damage and apoptotic cell death in HUVECs after 24 h of exposure with methomyl, metalaxyl, carbaryl, and pendimethalin. This is a first study on HUVECs signifying the cytotoxic–genotoxic and apoptotic potential of carbamate insecticides (methomyl and carbaryl), fungicide (metalaxyl), and herbicide (pendimethalin). Overall, these pesticides may affect ECs functions and angiogenesis; nonetheless, mechanistic studies are warranted from the perspective of vascular biology using in vivo test models.

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“…Nowadays, no harmonized list of PFs is available, therefore, a processing factor of 1 for all quantified pesticide residues was used [ 25 ]. However, some available studies show that PFs were fairly lower for a large number of pesticide residues, ranging from PF = 0.008 for less polar pesticide, such as ametoctradin, to PF = 1.6 for polar pesticide, such as imidacloprid [ 10 , 26 , 27 ]. On this account, it could be presumed, that the contamination of wine grapes was relatively high.…”

Section: Resultsmentioning

confidence: 99%

“…Hence, the presence of metabolites of these chemicals in organic products could be utilized as a marker of an unauthorized pesticide application even if the parent pesticide is not detectable. The possible transfer of parent pesticides and their metabolites from grapes into wines makes this strategy potentially useful also for authentication of organic wines [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Pesticide Residues and Their Metabolites in Grapes and Wines from Conventional and Organic Farming System

Schusterova

Hajšlová

Kocourek

et al. 2021

Foods

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In this study, the occurrence of pesticide residues and their metabolites in grapes and wines was investigated. A targeted analysis of 406 pesticide residues in 49 wine and grape samples from organic and conventional production were performed using the QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction method, followed by ultra-high-performance liquid chromatography coupled with tandem mass spectrometry. Multiple residues (>4 residues/sample) were detected in 22 tested samples. The most commonly detected residues were fungicides (e.g., boscalid) and insecticides (e.g., methoxyfenozide). An ultra-high-performance liquid chromatography–high resolution mass spectrometry method (UHPLC–(HR)MS) was used for screening of pesticide metabolites. We also provide a method and database for detecting pesticide metabolites (extending our previously published database to 49 metabolites originating from 25 pesticides). An introduced strategy of targeted screening of pesticide metabolites was applied for authentication of 27 organic grapes and wines. In total, 23 samples were free of quantifiable residues/detected metabolites or contained residues approved for organic production.

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Rapid analysis and residue evaluation of six fungicides in grape wine-making and drying

Cited by 30 publications

References 23 publications

Monitoring the behavior of imazalil and its metabolite in grapes, apples, and the processing of fruit wine at enantiomeric level

Monitoring the behavior of imazalil and its metabolite in grapes, apples, and the processing of fruit wine at enantiomeric level

Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells

Pesticide Residues and Their Metabolites in Grapes and Wines from Conventional and Organic Farming System

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