Rapid analytical CEST spectroscopy of competitive host–guest interactions using spatial parallelization with a combined approach of variable flip angle, keyhole and averaging (CAVKA)

Morik, Hen-Amit; Schuenke, Patrick; Schröder, Leif

doi:10.1039/d2cp01099b

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…Some of these techniques are prone to image blurring as fast exchange causes the above‐mentioned highly effective T 2 decay (Kunth & Schröder, 2021). A well‐chosen approach for segmenting the magnetization into equal fractions is beneficial (Morik et al, 2022).…”

Section: Nanomaterials In Hyperpolarization For Medical Imagingmentioning

confidence: 99%

Nanomaterials for hyperpolarized nuclear magnetic resonance and magnetic resonance imaging

Saul

Schröder

Schmidt

et al. 2023

WIREs Nanomed Nanobiotechnol

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Nanomaterials play an important role in the development and application of hyperpolarized materials for magnetic resonance imaging (MRI). In this context they can not only act as hyperpolarized materials which are directly imaged but also play a role as carriers for hyperpolarized gases and catalysts for para-hydrogen induced polarization (PHIP) to generate hyperpolarized substrates for metabolic imaging. Those three application possibilities are discussed, focusing on carbon-based materials for the directly imaged particles.An overview over recent developments in all three fields is given, including the early developments in each field as well as important steps towards applications in MRI, such as making the initially developed methods more biocompatible and first imaging experiments with spatial resolution in either phantoms or in vivo studies. Focusing on the important features nanomaterials need to display to be applicable in the MRI context, a wide range of different approaches to that extent is covered, giving the reader a general idea of different possibilities as well as recent developments in those different fields of hyperpolarized magnetic resonance.

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Section: Nanomaterials In Hyperpolarization For Medical Imagingmentioning

confidence: 99%

Nanomaterials for hyperpolarized nuclear magnetic resonance and magnetic resonance imaging

Saul

Schröder

Schmidt

et al. 2023

WIREs Nanomed Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

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Three‐dimensional radial echo‐planar spectroscopic imaging for hyperpolarized ¹³C MRSI in vivo

Awenius,

Abeln,

Müller

et al. 2024

Magnetic Resonance in Med

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PurposeTo demonstrate the feasibility of 3D echo‐planar spectroscopic imaging (EPSI) technique with rapid volumetric radial k‐space sampling for hyperpolarized (HP) 13C magnetic resonance spectroscopic imaging (MRSI) in vivo.MethodsA radial EPSI (rEPSI) was implemented on a 3 T clinical PET/MR system. To enable volumetric coverage, the sinusoidal shaped readout gradients per k‐t‐spoke were rotated along the three spatial dimensions in a golden‐angle like manner. A distance‐weighted, density‐compensated gridding reconstruction was used, also in cases with undersampling of spokes in k‐space. Measurements without and with HP 13C‐labeled substances were performed in phantoms and rats using a double‐resonant 13C/1H volume resonator with 72 mm inner diameter.ResultsPhantom measurements demonstrated the feasibility of the implemented rEPSI sequence, as well as the robustness to undersampling in k‐space up to a factor of 5 without advanced reconstruction techniques. Applied to measurements with HP [1‐13C]pyruvate in a tumor‐bearing rat, we obtained well‐resolved MRSI datasets with a large matrix size of 123 voxels covering the whole imaging FOV of (180 mm)3 within 6.3 s, enabling to observe metabolism in dynamic acquisitions.ConclusionAfter further optimization, the proposed rEPSI method may be useful in applications of HP 13C‐tracers where unknown or varying metabolite resonances are expected, and the acquisition of dynamic, volumetric MRSI datasets with an adequate temporal resolution is a challenge.

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Cest Mri

Kunth,

Schröder

2024

Quantification of Biophysical Parameters in Medical Imaging

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Rapid analytical CEST spectroscopy of competitive host–guest interactions using spatial parallelization with a combined approach of variable flip angle, keyhole and averaging (CAVKA)

Abstract: A serious limitation of high resolution 129Xe chemical exchange saturation transfer (CEST) NMR spectroscopy for comparing competitive host-guest interactions from different samples is the long acquisition time due to step-wise...

Cited by 3 publications

References 40 publications

Nanomaterials for hyperpolarized nuclear magnetic resonance and magnetic resonance imaging

Nanomaterials for hyperpolarized nuclear magnetic resonance and magnetic resonance imaging

Three‐dimensional radial echo‐planar spectroscopic imaging for hyperpolarized ¹³C MRSI in vivo

Cest Mri

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Rapid analytical CEST spectroscopy of competitive host–guest interactions using spatial parallelization with a combined approach of variable flip angle, keyhole and averaging (CAVKA)

Abstract: A serious limitation of high resolution 129Xe chemical exchange saturation transfer (CEST) NMR spectroscopy for comparing competitive host-guest interactions from different samples is the long acquisition time due to step-wise...

Cited by 3 publications

References 40 publications

Nanomaterials for hyperpolarized nuclear magnetic resonance and magnetic resonance imaging

Nanomaterials for hyperpolarized nuclear magnetic resonance and magnetic resonance imaging

Three‐dimensional radial echo‐planar spectroscopic imaging for hyperpolarized 13C MRSI in vivo

Cest Mri

Contact Info

Product

Resources

About

Three‐dimensional radial echo‐planar spectroscopic imaging for hyperpolarized ¹³C MRSI in vivo