Rapid and Precise In Vivo Measurement of Human Corneal Thickness with Optical Low-Coherence Reflectometry in Normal Human Eyes

Waelti, Rudolf; Böhnke, Matthias; Gianotti, R.; Bonvin, Pascal; Ballif, Julien J.; Salathé, René-Paul

doi:10.1117/1.429880

Cited by 31 publications

(15 citation statements)

References 32 publications

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“…Other studies have compared the OLCR pachymeter with the ultrasound pachymeter. Wa¨lti (1998) found the OLCR pachymeter to be faster and more precise (lower SD) than an ultrasound pachymeter. The CCT values were found to be significantly higher when measured with an ultrasound pachymeter than when measured with the OLCR pachymeter (Ventura et al 2001;Genth et al 2002).…”

Section: Introductionmentioning

confidence: 99%

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Central corneal thickness in high myopia

Pedersen

Hjortdal

Ehlers

2005

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To examine if central corneal thickness (CCT) is different in emmetropia and high myopia. Methods: 57 emmetropic subjects (0 to + 1.5 D) and 48 high myopes (all more than -6 D in spherical equivalent refraction) were studied. CCT was measured by a Haag-Streit Optical Low-Coherence Reflectometry (OLCR) pachymeter, a recently developed high precision pachymeter with a standard deviation (SD) for repeated measurements of 1 mm. Results: Mean CCT for the emmetropic group was 538.6 mm (SD = 32.1), and for the myopic group 527.7 mm (SD = 35.0). Neither the mean CCT nor the variance from the two groups showed a statistically significant different (p > 0.05). Conclusion: CCT is not systematically altered in myopia. The process by which the myopia progresses does not to a measurable degree influence the central cornea.

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Section: Introductionmentioning

confidence: 99%

“…The OLCR pachymeter is an automatic non-contact pachymeter based on interferometry. The pachymeter is easy to use and an average CCT measurement (based on 20 scans) takes 28 seconds including adjustment of the apparatus (Wa¨lti 1998).…”

Section: Equipmentmentioning

confidence: 99%

Central corneal thickness in high myopia

Pedersen

Hjortdal

Ehlers

2005

Acta Ophthalmologica Scandinavica

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“…15 The design of the optical reflectometer is based on a Michelson interferometer. 15 The design of the optical reflectometer is based on a Michelson interferometer.…”

Section: Methodsmentioning

confidence: 99%

“…10 A recent book on optical time-domain reflectometry is a useful source of information on the physical principles of reflectometry. 15 With this equipment, we set out to study the precision and reproducibility of repeated measurements of corneal thickness in one subject as well as day to day variations of corneal thickness on three consecutive days. [12][13][14] The instrument has been designed to be mounted on the slit lamp equipment used by ophthalmologists to perform biomicroscopy.…”

Section: Introductionmentioning

confidence: 99%

Precision and Reproducibility of Measurements of Human Corneal Thickness with Rapid Optical Low-Coherence Reflectometry (OLCR)

Boehnke

Masters²,

Waelti

et al. 1999

J. Biomed. Opt.

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This study investigates the precision and intraindividual variability of a clinical optical pachometer based on low-coherence reflectometry, which was used to measure the central thickness of a human cornea in vivo. The instrument, attached to a slit lamp, is a single mode fiber optic based Michelson interferometer with a high repetition rate as previously described. The same operator performed ten sets of measurements on the same subject, each consisting of 20 consecutive scans, on each day for three consecutive days. By computing the means from every scan series, the thickness of the central cornea with optical pachometry was found to be 519.6±1.2 (range 518-521) μm on day 1, 519.9±0.9 (range 519-521) μm on day 2, and 523.8±0.6 (range 523-525) μm on day 3. The thickness values on day 3, where the subject suffered from a cold without clinical ocular involvement, were different from the two previous days (p<0.001, one way analysis of variance). Optical low-coherence reflectometry measurements of corneal thickness can be performed with high precision of about 1 μm and a high intra- and intersession reproducibility. © 1999 Society of Photo-Optical Instrumentation Engineers.

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“…This pachymeter showed high precision 25,28,29 and excellent correlation with contact US pachymetry (0.99 correlation coefficient) on normal corneas. 25,26 Moreover, it is a noncontact pachymeter (ie, no risk of infection, no drops needed, and no indentation effect).…”

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confidence: 86%