Rapid and sensitive multiresidue analysis of pesticides in tobacco using low pressure and traditional gas chromatography tandem mass spectrometry

Khan, Zareen; Girame, Rushali; Utture, Sagar C.; Ghosh, Rakesh Kumar; Banerjee, Kaushik

doi:10.1016/j.chroma.2015.09.070

Cited by 15 publications

(6 citation statements)

References 17 publications

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“…Exposure to tobacco smoke has earlier been related to PR exposure, 70 and the dietary intake of fruits and vegetables has been associated with urinary concentrations of chlorpyrifos metabolites, 71 pyrethroid metabolites and organophosphate metabolites such as dialkyl and diethyl phosphates (DAP, DEP). 29,33−35 The relative higher consumption of fruit and vegetables by persons opting for organic and/or vegetarian food choices may thus increase PR exposure, but the health benefits of including fruit and vegetables in the diet outweigh the potential negative effects.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Exposure to tobacco smoke has earlier been related to PR exposure, and the dietary intake of fruits and vegetables has been associated with urinary concentrations of chlorpyrifos metabolites, pyrethroid metabolites and organophosphate metabolites such as dialkyl and diethyl phosphates (DAP, DEP). ,− The relative higher consumption of fruit and vegetables by persons opting for organic and/or vegetarian food choices may thus increase PR exposure, but the health benefits of including fruit and vegetables in the diet outweigh the potential negative effects . Population-wide assessment studies in Belgium and France have shown that the total dietary exposure to most PRs is between 4 and 100 times lower than the acceptable daily intake (ADI). , Also, diets that include organic and/or vegetarian food choices are often strongly correlated with other indicators of healthy lifestyle …”

Section: Resultsmentioning

confidence: 99%

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Silicone Wristband Passive Samplers Yield Highly Individualized Pesticide Residue Exposure Profiles

Aerts

Joly

Szternfeld

et al. 2017

Environ. Sci. Technol.

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Monitoring human exposure to pesticides and pesticide residues (PRs) remains crucial for informing public health policies, despite strict regulation of plant protection product and biocide use. We used 72 low-cost silicone wristbands as noninvasive passive samplers to assess cumulative 5-day exposure of 30 individuals to polar PRs. Ethyl acetate extraction and LC-MS/MS analysis were used for the identification of PRs. Thirty-one PRs were detected of which 15 PRs (48%) were detected only in worn wristbands, not in environmental controls. The PRs included 16 fungicides (52%), 8 insecticides (26%), 2 herbicides (6%), 3 pesticide derivatives (10%), 1 insect repellent (3%), and 1 pesticide synergist (3%). Five detected pesticides were not approved for plant protection use in the EU. Smoking and dietary habits that favor vegetable consumption were associated with higher numbers and higher cumulative concentrations of PRs in wristbands. Wristbands featured unique PR combinations. Our results suggest both environment and diet contributed to PR exposure in our study group. Silicone wristbands could serve as sensitive passive samplers to screen population-wide cumulative dietary and environmental exposure to authorized, unauthorized and banned pesticides.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Silicone Wristband Passive Samplers Yield Highly Individualized Pesticide Residue Exposure Profiles

Aerts

Joly

Szternfeld

et al. 2017

Environ. Sci. Technol.

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show abstract

“…Because of the intense use of agrotoxics in this crop, this soil presents low levels of organic matter and has significant levels of pesticides and herbicides. Consequently, it cannot be used in food production. , Thus, one solution to these issues is the cultivation of tobacco for energetic uses.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, it cannot be used in food production. 4,5 Thus, one solution to these issues is the cultivation of tobacco for energetic uses.…”

Section: Introductionmentioning

confidence: 99%

Pyrolysis of Residual Tobacco Seeds: Characterization of Nitrogen Compounds in Bio-oil Using Comprehensive Two-Dimensional Gas Chromatography with Mass Spectrometry Detection

et al. 2017

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Energetic tobacco (EnT) is a type of genetically modified tobacco with a focus on energy. Its seeds are larger and appear in greater quantity than those of conventional tobacco. This plant easily adapts to unproductive soils and is practically free of nicotine. The oil seed from EnT can be used for producing biodiesel without competition with edible oils. Additionally, the resulting residual cake can be thermally degraded to bio-oil and biochar through pyrolysis processes. In this study, the fast pyrolysis (700 °C at 100 °C min–1) of the residual cake of EnT seeds was performed in a fixed bed reactor (quartz), yielding approximately 40% (in mass) liquid products (bio-oil and an aqueous phase). After removal of the aqueous phase, the organic phase was submitted to an acid–alkaline extraction of the N-compounds in a simple and efficient way. The bio-oil and alkaline extract were analyzed by comprehensive two-dimensional gas chromatography coupled to fast-quadrupole mass spectrometry. Compounds were tentatively identified by similarity with a commercial library of mass spectra and using retention indexes. The main classes of compounds identified were phenols, hydrocarbons, and N-compounds (imidazole, pyridine, and their derivatives), with the potential to be applied in the chemical and pharmaceutical industries as well as biofuel production. The alkaline extraction resulted in the isolation of the main N-components, a finding fundamental for the utilization of these compounds for the production of pharmaceuticals, pesticides, and polymers.

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“…Employment of a switching valve between the pre-column and separation column during solvent evaporation allowed the LC solvent to be completely removed, preventing it from reaching the GC column and detector, besides reducing loss of volatile components, permitting large volume of LC eluent and preventing decomposition of labile compounds, which was not achieved with other interfaces previously developed. Afterwards, Khan et al (2015) employed low-pressure gas chromatography technique tandem triple quadrupole mass spectrometry (LPGC-MS/MS) for the determination of 259 multipesticide residues in tobacco. The optimized LPGC-MS/MS methodology was three-times faster than the usual GC-MS/MS and provided low LOQs (<2 µg/L) for all compounds, which could be achieved due to an average 2-3-times enhancement in signal/noise.…”

Section: Pesticidesmentioning

confidence: 99%

Trends in Analytical Methods for Analysis of Tobacco Products: An Overview

Costa

Vasconcelos²,

Moura³

et al. 2022

R. Eletr. TECCEN

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Abstract. Currently, due to the strong trends in policies to reduce smoking, several concerns related to quality control and regulation of tobacco products have been raised, as a great variety of products are available to consumers in the market. Considering that development of robust and selective analytical methods for tobacco and derivative products has been an important and necessary task over the years, however laborious, due to the complexity of the matrices. This work presents an overview of advances, innovation, and trends in analytical methods, focused on the chromatographic analysis of nicotine, tobacco-specific nitrosamines (TSNAs), humectants, pesticides, polycyclic aromatic hydrocarbons (PAHs) and sugars in different tobacco products. Gas chromatography (GC) coupled with different detectors is widely used to analyze nicotine, humectants and TSNAs in tobacco leaves and derivative products, while liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been frequently used to analyze TSNAs in mainstream cigarette smoke and smokeless tobacco products. Pesticides were mainly analyzed in tobacco using GC or LC coupled with mass detector (MS), while PAHs and sugars were generally analyzed in tobacco and smoke using LC-MS and GC-MS techniques, respectively. In addition to already established methods and despite the lack of a worldwide standardization of methods, significant efforts have been made to develop analytical procedures for a wide variety of tobacco products, with a broad range of innovative chromatographic methods available. In this sense, a potential trend is the possibility of simultaneous determination of multiple components aiming to reduce the analysis time. The present study examined the main works that developed or improved analytical methods for identifying and quantifying priority compounds in different tobacco matrices and aims to contribute to future research with this objective, in addition, to promoting standardization of technical terms used in this analytical area. It is noteworthy that some of the methods mentioned here have not been validated and further studies are needed in order to obtain reproducible analytical methods for regulatory purposes. Keywords: chromatography analyses; tobacco leaves; cigarette; cigarette smoke; smokeless tobacco products.

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Rapid and sensitive multiresidue analysis of pesticides in tobacco using low pressure and traditional gas chromatography tandem mass spectrometry

Cited by 15 publications

References 17 publications

Silicone Wristband Passive Samplers Yield Highly Individualized Pesticide Residue Exposure Profiles

Silicone Wristband Passive Samplers Yield Highly Individualized Pesticide Residue Exposure Profiles

Pyrolysis of Residual Tobacco Seeds: Characterization of Nitrogen Compounds in Bio-oil Using Comprehensive Two-Dimensional Gas Chromatography with Mass Spectrometry Detection

Trends in Analytical Methods for Analysis of Tobacco Products: An Overview

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