Rapid assay for procaine penicillin G in pharmaceutical dosages by spectrofluorimetry

Pulgarı́n, José A. Murillo; Molina, Aurelia Alañón

doi:10.1016/0039-9140(93)80188-w

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…A method for the spectrofluorimetric determination (k ex = 294 nm, k em = 348 nm) of procaine PEN-G in ethanol/water medium (60% v/v), at apparent pH = 9.9 (by ammonium/ammonia buffer solution pH = 10.0), was proposed for the analysis of commercial injections containing procaine PEN-G, PEN-G and/or benzathine PEN-G [129].…”

Section: Nonchromatographic Techniquesmentioning

confidence: 99%

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Samanidou

Evaggelopoulou

Papadoyannis³

2006

J of Separation Science

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Natural penicillin (benzylpenicillin) is the oldest antibiotic observed by Alexander Fleming in 1928. To broaden its spectrum of activity, natural penicillin was modified, giving rise to a group of antibiotics under the name 'penicillins'. Although an increasing number of bacteria appear to be resistant to them, penicillins are used to treat a variety of bacterial infections including Gram-positive, Gram-negative aerobic and anaerobic bacteria. Consequently, they are widely used in human and veterinary medicine to prevent and treat diseases. This review covers the analytical methodologies, mainly chromatographic, employed to the penicillins determination in pharmaceutical formulations, biological fluids and in production-scale fermentations reported in the literature. Results of published assays are comparatively presented focusing on sample preparation regarding isolation and purification, chromatographic conditions and method validation. Information on chemical structure, spectrum of activity and action mechanism of common penicillins has also been given.

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Section: Nonchromatographic Techniquesmentioning

confidence: 99%

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Samanidou

Evaggelopoulou

Papadoyannis³

2006

J of Separation Science

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Determination of ternary mixtures of penicillin G, benzathine and procaine by liquid chromatography and factorial design study

Ghassempour

Davarani

Noroozi³

et al. 2005

Talanta

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Use of Cerium (IV) in the Spectrophotometric and Spectrofluorimetric Determinations of Penicillins and Cephalosporins in Their Pharmaceutical Preparations

Walily

Gazy

Belal

et al. 2000

Spectroscopy Letters

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Spectrophotometric and spectrofluorimetric procedures for the quantitative determination of four penicillins [Amoxycillin (AMX), Bacampicillin (RAC), Piperacillin (PI") and Sultamcillin (SULT)] and ten cephalosporins [Cefadroxil (CDL), Cefamandole nafate (MAN), Cefuroxime axetil or sodium (CFX), Cefaclor (CFCR), Ceftazidime (CZD), Ceftizoxime (CTIZ),Ceftriaxone (CTRX), Cefoperazone (CPZ), Cefixime (CXIM) and Cefpodoxime proxetil (CFPD)] are described. Both methods are based on the acidic oxidation of the antibiotics with cerium (IV) at elevated temperature.

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Rapid assay for procaine penicillin G in pharmaceutical dosages by spectrofluorimetry

Cited by 3 publications

References 14 publications

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Determination of ternary mixtures of penicillin G, benzathine and procaine by liquid chromatography and factorial design study

Use of Cerium (IV) in the Spectrophotometric and Spectrofluorimetric Determinations of Penicillins and Cephalosporins in Their Pharmaceutical Preparations

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