Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Abstract

Aims/hypothesis: Basal plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous, competitive inhibitor of nitric oxide synthase, is elevated in patients with type 2 diabetes. ADMA may contribute to the endothelial dysfunction and associated vascular complications observed in individuals with type 2 diabetes. The present study investigated the effect of 12 weeks of supervised walking exercise on plasma ADMA concentration in women aged 65-74 years with type 2 diabetes. Materials and methods:Fourteen women (aged 69 ± 3 yrs) with uncomplicated type 2 diabetes, completed 12 weeks of supervised, moderate-intensity walking at an intensity equivalent to their individual gas-exchange threshold. Blood was sampled for ADMA concentration before and after a 6-week intervention-free control period, and again after 6 and 12 weeks of exercise training.Results: Plasma ADMA concentration was found to be significantly lower after 12-weeks of exercise training when compared with baseline (0 wk) measurements. These results were accompanied by significant increases in time to exhaustion, relative and absolute peak oxygen uptake, and oxygen uptake at gas-exchange threshold. Conclusion/interpretation:Regular, moderate-intensity exercise decreases circulating ADMA concentrations in older women with type 2 diabetes. These results suggest that ADMA may play a role in the training-induced reduction in cardiovascular disease risk seen with exercise training in individuals with type 2 Diabetes.

The Effect of Aerobic Training with Vitamin C Supplementation on Myeloperoxidase, Asymmetric Dimethyl Arginine and Blood Pressure in Middle-Age Hypertensive Overweight Men

“…The results of the present research also showed that the serum level of ADMA decreased significantly in hypertensive individuals after aerobic training with alongside vitamin C supplementation compared to the baseline. The findings are congruent with the results of Shabaaninia et al, and Serre et al, (18,21). However, Tanahashi et al reported that aerobic training could increase ADMA in post-menopausal women (22).…”

1H-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium–vitamin-D3supplementation in older men

“…These 3 methylamines have been shown to be metabolically related (Mitchell et al 2007). Dimethylamine is a metabolic byproduct of dimethylarginine (involved in nitric oxide synthesis), and has been reported to be elevated in patients with hypertension and cardiac dysfunction (Achan et al 2003;Böger 2005), but decreased in plasma and urine of exercise-trained patients (Schlager et al 2011;Serre et al 2011).…”

Late Stage Complications of Diabetes and Insulin Resistance

“…Type 2 diabetes mellitus (T2DM) is a progressive disease characterized by gradual decline in beta-cell function and insulin resistance [77]. Type 2 diabetes is associated with a two-to-three fold higher incidence of macrovascular atherosclerotic disease compared to non diabetic individuals [78].…”