Rapid communication: linkage and physical mapping of the porcine melanocortin-4 receptor (MC4R) gene.

Kim, K. S.; Larsen, N. K.; Rothschild, Max F.

doi:10.2527/2000.783791x

Cited by 41 publications

(28 citation statements)

References 6 publications

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“…= 2) indicating that the locus is not under selection pressure. This result (wildtype: 0.59 versus mutant: 0.41) is in the same range as described for Large White‐derived lines (0.56 versus 0.44; Kim et al. 2000a).…”

Section: Resultssupporting

confidence: 82%

“…Genomic DNA was extracted from hair roots according to standard methods. The following primers were designed with the software OLIGO 5.0 (MedProbe, As, Norway) on the basis of the sequence published by Kim et al. 2000a; GenBank entry ): 5′‐ACA GTT AAG CGG GTT GGA AT‐3′ (forward) and 5′‐CAG GGG ATA GCA ACA GAT GA‐3′ (reverse).…”

Section: Methodsmentioning

confidence: 99%

“…2004). The porcine MC4R locus was mapped to SSC1 q22–q27 and a missense mutation (Asp298Asn) was identified by Kim et al. (2000a).…”

Section: Introductionmentioning

confidence: 99%

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Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs

Jokubka

Maak

Kerzienė

et al. 2006

J Animal Breeding Genetics

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The melanocortin 4 receptor is expressed in virtually all brain regions of mammals and plays an important role in energy homeostasis. Polymorphisms in this gene may thus be related to growth and obesity. In pigs, a non-synonymous polymorphic site was described (Asp298Asn) and demonstrated to affect cAMP production and to alter adenylyl cyclase signalling. Association studies revealed significant linkage of this mutation with production trait in pigs. In this study, 207 Lithuanian White pigs were genotyped at the MC4R locus and analysed on relationships between genotype and breeding values for several performance traits. The observed allele and genotype frequencies did not deviate significantly from Hardy-Weinberg equilibrium (wildtype allele 0.59; mutant allele 0.41) and are comparable with those described in other Large White populations. The mutant Asn298 allele of the MC4R gene was significantly associated with increased test daily gain, higher lean meat percentage and lower backfat thickness. There was a trend towards an improved feed conversion ratio (p = 0.065) in animals with the mutant allele whereas no significant effect was found on lifetime daily gain. These results indicate that the MC4R polymorphism should be integrated in selection programmes in the Lithuanian White to improve carcass composition.

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Section: Resultssupporting

confidence: 82%

Section: Methodsmentioning

confidence: 99%

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Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs

Jokubka

Maak

Kerzienė

et al. 2006

J Animal Breeding Genetics

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“…Kim et al (2004a) performed a functional analysis of the MC4R protein and found differences in cAMP production between the 298Asp and 298Asn variants. The porcine gene melanocortin-4 receptor (MC4R) was mapped on chromosome 1q22-q27 (Kim et al, 2000a).…”

mentioning

confidence: 99%

Effect of missense mutation Asp298Asn in MC4R on growth and fatness traits in commercial pig crosses in the Czech Republic

Dvořáková¹,

Stupka²,

Šprysl³

et al. 2011

CZECH J ANIM SCI

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Abstract:The current knowledge of factors regulating voluntary feed intake in pigs is quite limited. The objective of this study was to test the influence of the missense mutation p.Asp298Asn (AF087937:c.746G>A) of the MC4R gene on selected production traits in pig crosses. These crosses are commonly used on commercial farms in the Czech Republic. The allele frequencies of c.746G>A were as follows: G allele -0.59 and A allele -0.41. We detected statistically significant differences in the content of intramuscular fat in the musculus longissimus lumborum et thoracis, and a similar trend was observed in shoulder and neck. A allele correlated with higher values of fatness and G allele with a higher percentage of lean meat. However, we did not find any significant influence on either feed intake or growth rate in this study. For another mutation, p.Arg236His (NM_214173.1:c.707G>A), frequencies of alleles were disproportional (A allele -0.02 and G allele -0.98), only two genotypes were observed (AG and GG) and linkage disequilibrium was not detected. Therefore, we assume that the effect of this polymorphism on growth rate and fatness in the Czech population of pigs is negligible.

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“…Однонуклео-тидна заміна в сьомому екзоні гену МС4R веде до порушення проведення гормонального сигна-лу лептину через рецептор меланокортину, що безпосередньо впливають на ознаки відгодівель-но-м'ясної продуктивності свиней [13,15,16].…”

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Зв’язок Поліморфізмів Генів РLIN І Mc4r З Відгодівельними Якостями Свиней

Гиря¹,

Метлицька²,

Усачова³

et al. 2018

visnyk

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Rapid communication: linkage and physical mapping of the porcine melanocortin-4 receptor (MC4R) gene.

Cited by 41 publications

References 6 publications

Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs

Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs

Effect of missense mutation Asp298Asn in MC4R on growth and fatness traits in commercial pig crosses in the Czech Republic

Зв’язок Поліморфізмів Генів РLIN І Mc4r З Відгодівельними Якостями Свиней

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