The high concentration of cyanide in Dioscorea hispida dennst should be reduced through immersion in seawater and interaction with rubbing ash. Soaking seawater prepared in immersion time 12, 24, and 36 hours accompanied by the replacement of seawater every three hours, while interaction with rubbing ash was ready with 75% and 100% concentration of ash on 12, 24, and 36 hours of storage time respectively. Measurement of cyanide concentrations of Dioscorea hispida dennst samples was prepared by argentometry titration with Liebig method after through the steam distillation process. Based on the results of this study, it found that immersion time for 12, 24, and 36 hours could reduce cyanide concentrations about 48.30%, 64.44%, and 70.88%, respectively. The interaction by using 75% rubbing ash for 12, 24, and 36 hours, it can reduce 24.09%, 38.69%, and 51.42% cyanide concentration in Dioscorea hispida dennst tubers, respectively. The Dioscorea hispida dennst tubers smeared with100% rubbing ash for 12, 24, and 36 hours. It can reduce cyanide content in Dioscorea hispida dennst by 36.26%, 49.92%, and 59.63%, respectively. Further treatment with drying and fermentation produces Dioscorea hispida dennst with a lower concentration of cyanide about 88.68% with a soft and white texture.