Rapid determination of antiviral medication ribavirin in different feedstuffs using a novel magnetic molecularly imprinted polymer coupled with high‐performance liquid chromatography

Abstract

A novel magnetic molecularly imprinted polymer adsorbing material was successfully synthesized to detect ribavirin in animal feedstuff. Molecularly imprinted polymer was prepared through surface polymerization by using ribavirin as template molecule, methyl methacrylate, and γ‐methacryloxypropyl trimethoxy silane functionalized magnetic mesoporous silica as bifunctional monomers, and ethylene diglycidyl ether as crosslinking agent. The prepared magnetic molecularly imprinted polymer was characterized by scanning electron microscopy and infrared spectroscopy. Static and dynamic adsorption experiments and selective adsorption analysis were performed to evaluate the adsorption and selectivity of magnetic molecularly imprinted polymer. Different experiments were conducted to optimize the magnetic solid‐phase extraction conditions. Under optimal experimental conditions, a magnetic molecularly imprinted solid‐phase extraction coupled with high‐performance liquid chromatography method was successfully developed for ribavirin detection. The established method achieved a satisfactory linear range of 0.20–50 mg/L (R2 > 0.99) and a low detection limit (0.081 mg/kg). An average recovery of 92–105% with relative standard deviation of <6.5% was obtained upon the application of the developed method to detect ribavirin in real feedstuff samples. Thus, established method can be used for the rapid and simple separation and detection of added ribavirin in feedstuff.

A simplified molecularly imprinted ECL sensor based on Mn2SnO4 nanocubes for sensitive detection of ribavirin

“…3 Despite many countries prohibiting the abuse of RBV in poultry farming, cases of illegal adulteration still occur, leading to RBV accumulation, which can cause toxicity or other adverse reactions. 4,5 The residual RBV in food and the environment can eventually enter the human body through enrichment, resulting in adverse effects such as liver damage, kidney damage, hemolytic anemia, respiratory distress, and allergic reactions. 6 Therefore, it is an urgent need to develop a simple, rapid, sensitive, and reliable method for detecting RBV in animal-derived food.…”

Selective extraction of apixaban from plasma by dispersive solid‐phase microextraction using magnetic metal organic framework combined with molecularly imprinted polymer nanocomposite

“…Another advantage of MIPs are their favorable stability and excellent adsorption efficiency. Therefore, MIPs can be used for extraction of the target analytes in complex matrices [29][30][31][32].…”

Preparation of Magnetic Molecularly Imprinted Polymer for Methylene Blue Capture

“…Manipulation with an external magnetic field opens the possibility of unique applications for MMIPs, which may be used for solid-phase extraction of pollutants in water samples (pesticides, herbicides, antibiotics, dyes, heavy metals, etc.) [7,8,12,[15][16][17][18][19][20][21][22][23][24], photocatalytic and dark-condition degradation of pollutants [23], isolating active compounds contained in plants (alkaloids, flavonoids, terpenes, etc.) [12], enantioseparation [25], and the separation, purification, and detection of various biomolecules [22,[26][27][28].…”