Rapid HPLC and Direct Flow Injection Analysis Assay for the Determination of Trimetazidine HCl in Pharmaceutical Tablet Formulation

Altıokka, Göksel; Kircali, Kevser; Aboul‐Enein, Hassan Y.

doi:10.1080/10826070600832921

Cited by 7 publications

(5 citation statements)

References 13 publications

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“…UV detector was set at 210 nm. The sensitivity of this FIA method was 7.04 × 10 −7 M. The proposed method was supported by necessary validation parameters and was compared with the simple UV spectrophotomeric method, which was also proposed by the same authors (Altiokka et al 2006).…”

Section: Discussionmentioning

confidence: 71%

“…No statistical difference was found between this method and others (Issa et al 2005). Altiokka et al (2006) used a direct flow injection method with UV detection mode. As the solvent system, methanol:water (10:90; v/v) mixture was used.…”

Section: Flow Injection Analysis Methodsmentioning

confidence: 68%

“…Altiokka et al (2006) used a direct flow injection method with UV detection mode. As the solvent system, methanol:water (10:90; v/v) mixture was used.…”

Section: Discussionmentioning

confidence: 99%

“…TMZ was determined in its tablet dosage form using RP-LC and the measurement was carried out at 210 nm wavelength with UV detector (Altiokka et al 2006). Sensitivity was reported as 1.2 × 10 −7 M. The authors applied their method for the direct analysis of TMZ in tablet dosage forms (Altiokka et al 2006). LC with electrochemical detector was used for the trace determination of TMZ in human blood plasma.…”

Section: Hplc Methodsmentioning

confidence: 99%

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Trimetazidine Revisited: A Comprehensive Review of the Pharmacological Effects and Analytical Techniques for the Determination of Trimetazidine

Onay-Beşi̇kçi̇

Özkan

2008

Cardiovascular Therapeutics

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Trimetazidine (TMZ) is an effective and well‐tolerated antianginal drug that possesses protective properties against ischemia‐induced heart injury. Growing interest in metabolic modulation in recent years urged an up‐to‐date review of the literature on TMZ. This review consists of two major sections: (1) comprehensive and critical information about the pharmacological effects, mechanism of action, pharmacokinetics, side effects, and current usage of TMZ, and (2) developments in analytical techniques for the determination of the drug in raw material, pharmaceutical dosage forms, and biological samples.

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Section: Discussionmentioning

confidence: 71%

Section: Flow Injection Analysis Methodsmentioning

confidence: 68%

“…Altiokka et al (2006) used a direct flow injection method with UV detection mode. As the solvent system, methanol:water (10:90; v/v) mixture was used.…”

Section: Discussionmentioning

confidence: 99%

Section: Hplc Methodsmentioning

confidence: 99%

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Trimetazidine Revisited: A Comprehensive Review of the Pharmacological Effects and Analytical Techniques for the Determination of Trimetazidine

Onay-Beşi̇kçi̇

Özkan

2008

Cardiovascular Therapeutics

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“…TMZ enhances the use of myocardial glucose through several actions such as reactive oxygen species level reduction, modification of the composition of cellular lipids and oxidation inhibition of mitochondrial fatty acids. [ 1 ] Several analytical methods have been documented for determination of TMZ in human plasma and dosage forms, such as HPLC, [ 2–10 ] LC–MS, [ 11–15 ] GC–MS, [ 16,17 ] HPTLC, [ 18–20 ] spectrophotometry, [ 21–29 ] spectrofluorimetry, [ 29 ] potentiometry, [ 30,31 ] voltammetry, [ 32 ] and chemiluminescence. [ 33 ]…”

Section: Introductionmentioning

confidence: 99%

One‐pot synthesis of fluorescent nitrogen and sulfur–carbon quantum dots as a sensitive nanosensor for trimetazidine determination

et al. 2021

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Water‐soluble and highly stable N,S‐doped CQDs (N,S‐CQDs) were synthesized using a low‐cost strategy with citric acid and thiosemicarbazide in one step for use as a fluorescent nanosensor. The achieved N,S‐CQDs produced strong emission at 446 nm upon excitation at 370 nm and a high quantum yield of 58.5%. The quenching effect on the prepared N,S‐CQDs was utilized for determination of trimetazidine (TMZ) spectrofluorimetrically over a wide linear range 0.04–0.5 μM (0.0106–0.133 μg ml−1) and a low limit of detection of 0.01 μM (0.002 μg ml−1). Furthermore, CDs were used as a simple and rapid fluorescent probe to determine TMZ in its pharmaceutical formulations as well as in human plasma. The method was tested in compliance with International Council for Harmonisation guidelines. The results obtained were compared statistically with those given for a reported method showing no significant variation regards accuracy and precision.

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Design of Experiments–Design Space Approach for Development of Chaotropic Chromatography Method for Determination of Trimetazidine Dihydrochloride and Two Impurities

Milošević

Vemić²,

Čolović

et al. 2017

Chromatographia

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Rapid HPLC and Direct Flow Injection Analysis Assay for the Determination of Trimetazidine HCl in Pharmaceutical Tablet Formulation

Cited by 7 publications

References 13 publications

Trimetazidine Revisited: A Comprehensive Review of the Pharmacological Effects and Analytical Techniques for the Determination of Trimetazidine

Trimetazidine Revisited: A Comprehensive Review of the Pharmacological Effects and Analytical Techniques for the Determination of Trimetazidine

One‐pot synthesis of fluorescent nitrogen and sulfur–carbon quantum dots as a sensitive nanosensor for trimetazidine determination

Design of Experiments–Design Space Approach for Development of Chaotropic Chromatography Method for Determination of Trimetazidine Dihydrochloride and Two Impurities

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