Rapid initiation of repigmentation in vitiligo with Dead Sea climatotherapy in combination with pseudocatalase (PC‐KUS)

Schallreuter, K U; Moore, Julia; Behrens-Williams, Stephanie; Panske, Angela; Harari, Marco

doi:10.1046/j.1365-4362.2002.01463.x

Cited by 93 publications

(66 citation statements)

References 31 publications

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“…Removal of H 2 O 2 by antioxidant has been proven to be beneficial to patients. Several reports suggested that a topical substitution with a UVB-activated pseudocatalase can successfully remove epidermal H 2 O 2 and achieve remarkable repigmentation in vitiligo (13,14). In contrast, other researchers found that topical pseudocatalase was not effective for vitiligo in an open, single-center study (15).…”

Section: Introductionmentioning

confidence: 99%

Minocycline protects melanocytes against H2O2-inducedcell death via JNK and p38 MAPK pathways

Song

Xu²,

Pan³

et al. 2008

Int J Mol Med

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Abstract.Vitiligo is an acquired and progressive disorder manifested by the selective destruction of melanocytes in the skin. An extremely high level of hydrogen peroxide (H 2 O 2 ) in plasma as well as in lesional skin has been reported in vitiligo patients. High H 2 O 2 level has been suggested to be responsible for the disappearance of melanocytes in vitiligo. JNK and p38 MAPK are strongly induced by oxidative stress and related to neuron loss in neurodegenerative disorders. Minocycline, an antibiotic possessing antioxidant activity, is capable of attenuating oxidative stress-induced neurotoxicity. To investigate whether minocycline rescues melanocytes from H 2 O 2 -induced apoptosis, cultured mouse melanocytes (B10BR) were treated with H 2 O 2 in the presence or absence of minocycline. Our data showed that H 2 O 2 decreases cell viability in a concentration-dependent manner which is attenuated by minocycline. Also, H 2 O 2 treatment activates JNK and p38 MAPK, and executive caspase 3 in B10BR cells. Minocycline significantly inhibits H 2 O 2 -induced activation of JNK, p38 MAPK and caspase 3. Collectively, we concluded that minocycline protects melanocytes against H2O2-induced apoptosis in vitro. Its protective effect is associated with the inhibition of JNK and p38 MAPK. Our findings suggest that minocycline, a clinically well-tolerated, safe antibiotic, may be used to prevent melanocyte loss in the early stage of vitiligo.

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Section: Introductionmentioning

confidence: 99%

Minocycline protects melanocytes against H2O2-inducedcell death via JNK and p38 MAPK pathways

Song

Xu²,

Pan³

et al. 2008

Int J Mol Med

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“…The basis for the use of this agent in vitiligo is the evidence of oxidative stress and high H 2 O 2 levels in the lesional skin 37 . While some earlier studies demonstrated excellent results with this agent in inducing repigmentation in vitiligo, later studies have cast doubts on its efficacy 38 .…”

Section: Pseudocatalasementioning

confidence: 99%

Vitiligo Management- An Update

Sarkar¹,

Sen²,

Mostofa³

2017

Faridpur Med Coll J

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Abstract:Vitiligo is an acquired, often progressive disorder of hypopigmentation. A lot of research has been conducted during the years yet its exact etiology still remains elusive. As a result even after so many years, there is no ideal treatment for vitiligo. Treatment options such as Narrowband Ultraviolet B (NB-UVB), Targeted Phototherapy, and Excimer laser on the medical front, in addition to epidermal cell transplantation and melanocyte culture transplants on the surgical front, have all revolutionized the management of this psychologically devastating disease.

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“…A rather uncommon, but effective, treatment modality is the combination of pseudocatalase and balneo/climatotherapy at the Dead sea (Krϋger et al, 2011; as cited in Schallreuter et al, 2002). Krϋger and colleagues showed in their study that group therapy had a strong and long-lasting positive effects in quality of life in vitiligo patients (Krϋger et al, 2011).…”

Section: Other Complementary Modalitiesmentioning

confidence: 99%

Role of Corticosteroids in Treatment of Vitiligo

Bagherani¹

2012

State of the Art of Therapeutic Endocrinology

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Rapid initiation of repigmentation in vitiligo with Dead Sea climatotherapy in combination with pseudocatalase (PC‐KUS)

Cited by 93 publications

References 31 publications

Minocycline protects melanocytes against H2O2-inducedcell death via JNK and p38 MAPK pathways

Minocycline protects melanocytes against H2O2-inducedcell death via JNK and p38 MAPK pathways

Vitiligo Management- An Update

Role of Corticosteroids in Treatment of Vitiligo

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