2016
DOI: 10.1109/jstqe.2015.2498478
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Rapid, Label-Free, and Highly Sensitive Detection of Cervical Cancer With Fluorescence Lifetime Imaging Microscopy

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Cited by 24 publications
(26 citation statements)
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“…In this study, we found the majority of patients presented lower I NADH /I FAD values in tumor tissues, which means a lower concentration of NADH and a higher concentration of FAD were in cancerous tissues compared with normal lung tissues. Our results agreed with some recent reports that the amount of FAD in tissues increased in the neoplasia, such as colonic cancer [44], cervical cancer [45], and human papillomavirus immortalized epithelial cells [46]. It implied the cellular metabolism changed due to the rapid tumor cell division.…”
Section: Discussionsupporting
confidence: 92%
“…In this study, we found the majority of patients presented lower I NADH /I FAD values in tumor tissues, which means a lower concentration of NADH and a higher concentration of FAD were in cancerous tissues compared with normal lung tissues. Our results agreed with some recent reports that the amount of FAD in tissues increased in the neoplasia, such as colonic cancer [44], cervical cancer [45], and human papillomavirus immortalized epithelial cells [46]. It implied the cellular metabolism changed due to the rapid tumor cell division.…”
Section: Discussionsupporting
confidence: 92%
“…Recently, our group reported another effective way for cervical cancer detection by FLIM method on unstained cervix sections, with rather high specificity and sensitivity at 100% and 90% [18]. Compared with FLIM, native fluorescence spectroscopy method involved in this study achieved same specificity and higher sensitivity.…”
Section: Discussionmentioning
confidence: 77%
“…Compared with FLIM, native fluorescence spectroscopy method involved in this study achieved same specificity and higher sensitivity. And the cost of fluorescence signal detection system in this study is modest, while that is high for the time-correlated single-photon counting (TCSPC) system of FLIM method [18]. And the cost of fluorescence signal detection system in this study is modest, while that is high for the time-correlated single-photon counting (TCSPC) system of FLIM method [18].…”
Section: Discussionmentioning
confidence: 98%
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“…Optical imaging techniques especially°uorescence lifetime imaging microscopy (FLIM) are promising for the detection of malignancies [1][2][3][4][5][6] Di®erentiating malignancies from normal tissues by auto-°u orescence can rely on the biochemical and tissue morphological changes. The traditional gold standard technique for tissue characterization is haematoxylin and eosin (H & E) stained histopathology, based on morphological changes.…”
Section: Introductionmentioning
confidence: 99%