Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine

Sofuoglu, Mehmet; Herman, Aryeh I.; Nadim, Haleh; Jatlow, Peter

doi:10.1038/npp.2011.336

Cited by 103 publications

(96 citation statements)

References 48 publications

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“…Another strength of this study was the biochemical verification of overnight abstinence and assessment of NMR, a factor relevant to subjective nicotine response (Sofuoglu et al, 2012) and previously proposed to contribute to sex differences in nicotine response (Benowitz et al, 2006). Importantly, sex and phase groups did not differ on NMR in this sample, suggesting our findings were likely not accounted for by nicotine metabolism differences.…”

Section: Strengths and Limitationsmentioning

confidence: 66%

“…These doses have previously been shown to be well tolerated, yet produce robust physiological and both positive and negative subjective effects in men and women Sofuoglu et al, 2008Sofuoglu et al, , 2011Sofuoglu et al, , 2012. Doses were administered in an escalating manner to avoid nicotine carryover into the saline dose and as a safety precaution.…”

Section: Methodsmentioning

confidence: 99%

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Subjective, Physiological, and Cognitive Responses to Intravenous Nicotine: Effects of Sex and Menstrual Cycle Phase

DeVito

Herman

Waters

et al. 2013

Neuropsychopharmacol

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Nicotine dependence is a serious public health concern. Optimal treatment of nicotine dependence will require greater understanding of the mechanisms that contribute to the maintenance of smoking behaviors. A growing literature indicates sex and menstrual phase differences in responses to nicotine. The aim of this study was to assess sex and menstrual phase influences on a broad range of measures of nicotine response including subjective drug effects, cognition, physiological responses, and symptoms of withdrawal, craving, and affect. Using a well-established intravenous nicotine paradigm and biochemical confirmation of overnight abstinence and menstrual cycle phase, analyses were performed to compare sex (age 18-50 years; 115 male and 45 female) and menstrual cycle phase (29 follicular and 16 luteal) effects. Females had diminished subjective drug effects of, but greater physiological responses to, nicotine administration. Luteal-phase females showed diminished subjective drug effects and better cognition relative to follicular-phase women. These findings offer candidate mechanisms through which the luteal phase, wherein progesterone is dominant relative to estradiol, may be protective against vulnerability to smoking.

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Section: Strengths and Limitationsmentioning

confidence: 66%

Section: Methodsmentioning

confidence: 99%

Subjective, Physiological, and Cognitive Responses to Intravenous Nicotine: Effects of Sex and Menstrual Cycle Phase

DeVito

Herman

Waters

et al. 2013

Neuropsychopharmacol

Self Cite

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“…When smokers were divided into quartiles based on NMR, the fastest metabolizers had a greater likelihood of abstinence from smoking with bupropion treatment than the slowest metabolizers (Patterson et al, 2008). According to the same quartile system, the slowest metabolizers had lower nicotine dependence, reported less cigarette craving following overnight abstinence, and less drug liking after intravenous nicotine compared to the fastest metabolizers (Sofuoglu et al, 2012). While NMR (considered as a continuous variable) was not associated with decreases in nicotine dependence produced by smoking reduced-nicotine cigarettes over 6 months in one study (Bandiera et al, 2015), the interaction of nicotine dose and NMR on the acute effects of smoking are unknown.…”

Section: Introductionmentioning

confidence: 99%

Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects

Faulkner

Ghahremani

Tyndale

et al. 2017

Neuropsychopharmacol

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The use of cigarettes delivering different nicotine doses allows evaluation of the contribution of nicotine to the smoking experience. We compared responses of 46 young adult smokers to research cigarettes, delivering 0.027, 0.110, 0.231, or 0.763 mg nicotine, and conventional cigarettes. On five separate days, craving, withdrawal, affect, and sustained attention were measured after overnight abstinence and again after smoking. Participants also rated each cigarette, and the nicotine metabolite ratio (NMR) was used to identify participants as normal or slow metabolizers. All cigarettes equally alleviated craving, withdrawal, and negative affect in the whole sample, but normal metabolizers reported greater reductions of craving and withdrawal than slow metabolizers, with dose-dependent effects. Only conventional cigarettes and, to a lesser degree, 0.763-mg nicotine research cigarettes increased sustained attention. Finally, there were no differences between ratings of lower-dose cigarettes, but the 0.763-mg cigarettes and (even more so) conventional cigarettes were rated more favorably than lower-dose cigarettes. The findings indicate that smoking-induced relief of craving and withdrawal reflects primarily non-nicotine effects in slow metabolizers, but depends on nicotine dose in normal metabolizers. By contrast, relief of withdrawal-related attentional deficits and cigarette ratings depend on nicotine dose regardless of metabolizer status. These findings have bearing on the use of reduced-nicotine cigarettes to facilitate smoking cessation and on policy regarding regulation of nicotine content in cigarettes. They suggest that normal and slow nicotine metabolizers would respond differently to nicotine reduction in cigarettes, but that irrespective of metabolizer status, reductions to o0.763 mg/cigarette may contribute to temporary attentional deficits.

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“…22 Women also metabolize nicotine more quickly, especially women who are pregnant or taking oral contraceptives, suggesting a link to increased estrogen levels. 23,24 A relationship between estrogen and nicotine metabolism has important clinical implications because quicker metabolism of nicotine is associated with more intense smoking, 25 greater reward from nicotine, 26 greater cravings to smoke after overnight smoking abstinence, 26 and poorer cessation outcomes. 27 Similar to estrogen, progesterone appears to have an impact on smoking behavior, but with effects in the opposite direction.…”

Section: Introductionmentioning

confidence: 99%

Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation

Weinberger¹,

Smith

Allen

et al. 2015

Nicotine & Tobacco Research

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Introduction: To determine the effect of ovarian hormones on smoking, we conducted a systematic review of menstrual cycle effects on smoking (i.e., ad lib smoking, smoking topography, and subjective effects) and cessation-related behaviors (i.e., cessation, withdrawal, tonic craving, and cue-induced craving). Methods: Thirty-six papers were identified on MEDLINE that included a menstrual-related search term (e.g., menstrual cycle, ovarian hormones), a smoking-related search term (e.g., smoking, nicotine), and met all inclusion criteria. Thirty-two studies examined menstrual phase, 1 study measured hormone levels, and 3 studies administered progesterone. Results: Sufficient data were available to conduct meta-analyses for only 2 of the 7 variables: withdrawal and tonic craving. Women reported greater withdrawal during the luteal phase than during the follicular phase, and there was a nonsignificant trend for greater tonic craving in the luteal phase. Progesterone administration was associated with decreased positive and increased negative subjective effects of nicotine. Studies of menstrual phase effects on the other outcome variables were either small in number or yielded mixed outcomes. Conclusions: The impact of menstrual cycle phase on smoking behavior and cessation is complicated, and insufficient research is available upon which to conduct meta-analyses on most smoking outcomes. Future progress will require collecting ovarian hormone levels to more precisely quantify the impact of dynamic changes in hormone levels through the cycle on smoking behavior. Clarifying the relationship between hormones and smoking-particularly related to quitting, relapse, and medication response-could determine the best type and timing of interventions to improve quit rates for women.

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Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine

Cited by 103 publications

References 48 publications

Subjective, Physiological, and Cognitive Responses to Intravenous Nicotine: Effects of Sex and Menstrual Cycle Phase

Subjective, Physiological, and Cognitive Responses to Intravenous Nicotine: Effects of Sex and Menstrual Cycle Phase

Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects

Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation

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