Rapid preparation method for technetium-99m bicisate

Hung, Joseph C.; Chowdhury, Sushital; Redfern, Maria G.; Mahoney, Douglas W.

doi:10.1007/s002590050101

Cited by 5 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The preparation was thoroughly mixed for a few seconds and allowed to stand for 30 minutes 15. A rapid preparation technique was alternatively used in which the contents were microwaved for 8 seconds at 300 W 32. The radiochemical purity was checked using paper chromatography to ensure that it was greater than 90% 33.…”

Section: Methodsmentioning

confidence: 99%

Comparative study of 99mTc-ECD and 99mTc-HMPAO for peri-ictal SPECT: qualitative and quantitative analysis

O’Brien

Brinkmann

Mullan

et al. 1999

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

Tc-HMPAO, thereby enhancing the sensitivity and the specificity of peri-ictal SPECT for the localisation of intractable partial epilepsy. (J Neurol Neurosurg Psychiatry 1999;66:331-339) Keywords: Ictal SPECT;99m Tc-ECD; 99m Tc-HMPAO Peri-ictal SPECT shows great promise as a tool to accurately localise seizures in intractable partial epilepsy, particularly in those with temporal lobe seizures. [1][2][3][4][5][6] Moreover, the recent development of computer aided methods of subtracting the interictal SPECT images from the ictal images, with the subsequent coregistration of the diVerence images on to the MRI, has been shown to further improve the clinical usefulness of SPECT, especially in extratemporal epilepsy and in epilepsy that is diYcult to localise. 7-13The radiopharmaceutical used in the vast majority of studies of peri-ictal SPECT has been technetium-99m-hexamethylpropylene amine oxime (

show abstract

Section: Methodsmentioning

confidence: 99%

Comparative study of 99mTc-ECD and 99mTc-HMPAO for peri-ictal SPECT: qualitative and quantitative analysis

O’Brien

Brinkmann

Mullan

et al. 1999

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

show abstract

“…In order to shorten the preparation time, alternative procedures for preparation of 99m Tc-l,l-ECD have been evaluated. Hung et al (1997) found that a 97.4% ± 0.5% radiochemical purity (RCP) could be obtained after an 8-s microwave heating time at 300 W (solution temperature at 69°C) and an average RCP value of 96.4% was maintained throughout the 24-h evaluation period. To prevent the possibility of radioactivity spillage caused by either ejection of the rubber stopper or shattering of the glass vial (Hung and Gibbons 1992), an acrylic plastic container should be used or, alternatively, incubation in a water bath at 69°C can replace the microwave heating.…”

Section: Brain Perfusion Imaging Agentsmentioning

confidence: 99%

Diagnostic Nuclear Medicine

2006

Medical Radiology

View full text Add to dashboard Cite

“…It was demonstrated that that the best heating temperature to obtain the 99m Tc-bicisate preparation was ≈70 • C and that the final radiolabeling results were the same using a hot water incubator or an MW oven at 300 W for 8 s. However, the MW oven is a better choice because of the faster and more uniform heating. With this protocol, a radiochemical purity >95% was obtained within 5 min post reconstitution [95].…”

Section: Technetium-99m and Rheniummentioning

confidence: 99%

Microwave-Assisted Synthesis: Can Transition Metal Complexes Take Advantage of This “Green” Method?

Gabano

Ravera

2022

Molecules

View full text Add to dashboard Cite

Microwave-assisted synthesis is considered environmental-friendly and, therefore, in agreement with the principles of green chemistry. This form of energy has been employed extensively and successfully in organic synthesis also in the case of metal-catalyzed synthetic procedures. However, it has been less widely exploited in the synthesis of metal complexes. As microwave irradiation has been proving its utility as both a time-saving procedure and an alternative way to carry on tricky transformations, its use can help inorganic chemists, too. This review focuses on the use of microwave irradiation in the preparation of transition metal complexes and organometallic compounds and also includes new, unpublished results. The syntheses of the compounds are described following the group of the periodic table to which the contained metal belongs. A general overview of the results from over 150 papers points out that microwaves can be a useful synthetic tool for inorganic chemists, reducing dramatically the reaction times with respect to traditional heating. This is often accompanied by a more limited risk of decomposition of reagents or products by an increase in yield, purity, and (sometimes) selectivity. In any case, thermal control is operative, whereas nonthermal or specific microwave effects seem to be absent.

show abstract

Rapid preparation method for technetium-99m bicisate

Cited by 5 publications

References 0 publications

Comparative study of 99mTc-ECD and 99mTc-HMPAO for peri-ictal SPECT: qualitative and quantitative analysis

Comparative study of 99mTc-ECD and 99mTc-HMPAO for peri-ictal SPECT: qualitative and quantitative analysis

Diagnostic Nuclear Medicine

Microwave-Assisted Synthesis: Can Transition Metal Complexes Take Advantage of This “Green” Method?

Contact Info

Product

Resources

About