Rapid printing of bio-inspired 3D tissue constructs for skin regeneration

Zhou, Feifei; Hong, Yi; Liang, Renjie; Zhang, Xianzhu; Liao, Youguo; Jiang, Deming; Zhang, Jiayan; Sheng, Zhaohan; Xie, Chang; Peng, Zhi; Zhuang, Xue; Bunpetch, Varitsara; Zou, Yiwei; Huang, Wenwen; Zhang, Qin; Alakpa, Enateri V.; Zhang, Shufang; Ouyang, Hongwei

doi:10.1016/j.biomaterials.2020.120287

Cited by 194 publications

(166 citation statements)

References 72 publications

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“…One emerging research line (the papers was not included in this scientometric analysis) illustrates the significant advances in the cell source-related technologies aimed at generating a safe and effective cell source for clinical use[ 112 - 114 ]. Nevertheless, the vast majority of the bioprinting studies conducted today use cells to develop proof-of-concept tissue constructs rather than functional tissues for transplantation[ 111 , 115 ].…”

Section: Bioinks For Different Bioprinting Technologiesmentioning

confidence: 99%

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Pedroza-González¹,

Rodríguez-Salvador²,

Pérez-Benítez³

et al. 2024

IJB

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This scientometric analysis of 393 original papers published from January 2000 to June 2019 describes the development and use of bioinks for 3D bioprinting. The main trends for bioink applications and the primary considerations guiding the selection and design of current bioink components (i.e., cell types, hydrogels, and additives) were reviewed. The cost, availability, practicality, and basic biological considerations (e.g., cytocompatibility and cell attachment) are the most popular parameters guiding bioink use and development. Today, extrusion bioprinting is the most widely used bioprinting technique. The most reported use of bioinks is the generic characterization of bioink formulations or bioprinting technologies (32%), followed by cartilage bioprinting applications (16%). Similarly, the cell-type choice is mostly generic, as cells are typically used as models to assess bioink formulations or new bioprinting methodologies rather than to fabricate specific tissues. The cell-binding motif arginine-glycine-aspartate is the most common bioink additive. Many articles reported the development of advanced functional bioinks for specific biomedical applications; however, most bioinks remain the basic compositions that meet the simple criteria: Manufacturability and essential biological performance. Alginate and gelatin methacryloyl are the most popular hydrogels that meet these criteria. Our analysis suggests that present-day bioinks still represent a stage of emergence of bioprinting technology.

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Section: Bioinks For Different Bioprinting Technologiesmentioning

confidence: 99%

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Pedroza-González¹,

Rodríguez-Salvador²,

Pérez-Benítez³

et al. 2024

IJB

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“…Some drug delivery systems have been constructed by 3D printing with excellent physico-mechanical properties ( Ng et al, 2016 ; Hafezi et al, 2019 ; Long et al, 2019 ; Karavasili et al, 2020 ). Printing interconnected microchannels ( Zhou et al, 2020 ) containing hydrogel could mimic functions of living skins that facilitates cell migration, proliferation, and new tissue formation.…”

Section: Fabrication Of Hydrogel For Wound Healingmentioning

confidence: 99%

Biomimetic Hydrogels to Promote Wound Healing

Fan

Saha

Hanjaya‐Putra

2021

Front. Bioeng. Biotechnol.

114

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Wound healing is a common physiological process which consists of a sequence of molecular and cellular events that occur following the onset of a tissue lesion in order to reconstitute barrier between body and external environment. The inherent properties of hydrogels allow the damaged tissue to heal by supporting a hydrated environment which has long been explored in wound management to aid in autolytic debridement. However, chronic non-healing wounds require added therapeutic features that can be achieved by incorporation of biomolecules and supporting cells to promote faster and better healing outcomes. In recent decades, numerous hydrogels have been developed and modified to match the time scale for distinct stages of wound healing. This review will discuss the effects of various types of hydrogels on wound pathophysiology, as well as the ideal characteristics of hydrogels for wound healing, crosslinking mechanism, fabrication techniques and design considerations of hydrogel engineering. Finally, several challenges related to adopting hydrogels to promote wound healing and future perspectives are discussed.

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“…A bioprinting setup, consisting of a Hewlett-Packard (HP) Deskjet thermal inkjet printer modified with an overhead UV lamp, was used to produce 3D printed PEGDMA bone constructs with Irgacure I-2959 as the photoinitiator [ 71 ]. In another study, Zhou et al developed a GelMA-based bioink suitable for DLP printing containing LAP photoinitiator and a hyaluronic acid (HA) derivative to create functional living skin for skin regeneration applications [ 59 ]. Another photopolymer, poly(propylene fumarate) (PPF), has been used in various biomedical applications including bone tissue engineering due to its similar compressive modulus values as human trabecular bone [ 72 ].…”

Section: Key Aspects Of Fabricating Parenteral Dosage Forms Via 3d Printingmentioning

confidence: 99%

Recent Advances in 3D Printing for Parenteral Applications

Ivone

Yang

Shen

2021

AAPS J

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3D printing has emerged as an advanced manufacturing technology in the field of pharmaceutical sciences. Despite much focus on enteral applications, there has been a lack of research focused on potential benefits of 3D printing for parenteral applications such as wound dressings, biomedical devices, and regenerative medicines. 3D printing technologies, including fused deposition modeling, vat polymerization, and powder bed printing, allow for rapid prototyping of personalized medications, capable of producing dosage forms with flexible dimensions based on patient anatomy as well as dosage form properties such as porosity. Considerations such as printing properties and material selection play a key role in determining overall printability of the constructs. These parameters also impact drug release kinetics, and mechanical properties of final printed constructs, which play a role in modulating immune response upon insertion in the body. Despite challenges in sterilization of printed constructs, additional post-printing processing procedures, and lack of regulatory guidance, 3D printing will continue to evolve to meet the needs of developing effective, personalized medicines for parenteral applications.

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Rapid printing of bio-inspired 3D tissue constructs for skin regeneration

Cited by 194 publications

References 72 publications

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Biomimetic Hydrogels to Promote Wound Healing

Recent Advances in 3D Printing for Parenteral Applications

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