Rapid Reduction of Severely Elevated Serum Triglycerides with Insulin Infusion, Gemfibrozil and Niacin

Poonuru, S.; Pathak, Sumedha R.; Vats, Hemender S.; Pathak, Ram D.

doi:10.3121/cmr.2010.898

Cited by 37 publications

(40 citation statements)

References 20 publications

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“…Options for treatment of substantial triglyceride elevations in the hospital setting include insulin drip therapy, heparin drip, and apheresis. 5 As noted above, our patient had acceptable results with initiation of insulin drip therapy to lower triglycerides. Insulin works by enhancing LPL activity and also acts as a powerful triglyceridelowering agent by facilitating production of enzymes necessary to transport triglycerides out of the plasma.…”

Section: Discussionsupporting

confidence: 53%

“…Insulin works by enhancing LPL activity and also acts as a powerful triglyceridelowering agent by facilitating production of enzymes necessary to transport triglycerides out of the plasma. 5 In the patient with diabetes with severely elevated triglyceride levels, the benefits of insulin are 2-fold: a reduction in glucose levels and a reduction in triglycerides.…”

Section: Discussionmentioning

confidence: 99%

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An 8-Year-Old Boy Presenting with Eruptive, Pruritic Rash and Cough

Cantrell¹

2016

Pediatr Ann

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

An 8-Year-Old Boy Presenting with Eruptive, Pruritic Rash and Cough

Cantrell¹

2016

Pediatr Ann

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“…32 A case report of nondiabetic adolescent patient with severe hypertriglyceremia, subcutaneous infusion of bolus dose of regular insulin at 0.1 U/kg decreased triglyceride level rapidly. 33 Heparin also release lipoprotein lipase from muscle, adipose tissue and endothelium to circulation and hydrolyze the triglyceride. This effect is short lived and is quickly followed by increased hepatic LPL degradation.…”

Section: Positive Imaging Findingsmentioning

confidence: 99%

An 8½ year old girl presented with pain abdomen with hypertriglyceremia

Nahar

Karim

Rukunuzzaman

et al. 2018

Bangabandhu Sheikh Mujib Medical University Journal

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This article has no abstract. The first 100 words appear below:A 8 ½ year old girl, 1st issue of non-consanguineous parents, from Norshingdi immunized as per EPI presented at the outpatient department with the history of abdominal pain for 5 days. The pain was located in the epigastric region and dull in nature. There was no aggravating or relieving factor and no radiation and persisted all the days. The pain had no relation with the food. She had also the history of vomiting for several times for the same duration which occurred usually after feed and contained food particle and not mixed with blood or bile and it was not projectile.

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“…4,5 Medications such as fenofibrate are considered first-line treatments to lower triglyceride levels, but they have a slow onset of action. Their mechanism of action includes increasing lipoprotein lipase levels and free fatty acid oxidation.…”

Section: A S E S T U D I E Smentioning

confidence: 99%

“…4,5 The blood is then supplemented with colloid solution and returned to the patient. TPE adequately reduced triglyceride levels by > 50% (from 5,500+ to 2,508 mg/dl) and the anion gap metabolic acidosis resolved almost immediately after the first of four treatments.…”

Section: A S E S T U D I E Smentioning

confidence: 99%